Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acacb (from a repository: Fri Apr 13 16:06:04 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins5 (38.46 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)27 (34.62 %)
The number (and %) of affected PPIs12 (44.44 %)
PPI diameter2
PPI radius1
The average degree of PPI2.923
Assortativity coefficient-0.4403
The network average Clustering coefficient0.495
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality8 (61.54 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acacb
user protein120.106111.333Biotin_carb_N (PF00289): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786): Carbamoyl-phosphate synthase L chain, ATP binding domain
Biotin_carb_C (PF02785): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364): Biotin-requiring enzyme
ACC_central (PF08326): Acetyl-CoA carboxylase, central region
Carboxyl_trans (PF01039): Carboxyl transferase domain
Ankrd28
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Bcor
oncogene31.0000BCOR (PF15808): BCL-6 co-repressor, non-ankyrin-repeat region
Ank_2 (PF12796): Ankyrin repeats (3 copies)
PUFD (PF16553): BCORL-PCGF1-binding domain
Dppa4
interactor40.6670.667Dppa2_A (PF14049): Dppa2/4 conserved region in higher vertebrates
DCR (PF14047): Dppa2/4 conserved region
Elavl1
oncogene31.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Huwe1
oncogene50.5002.667DUF908 (PF06012): Domain of Unknown Function (DUF908)
DUF913 (PF06025): Domain of Unknown Function (DUF913)
PBP_sp32 (PF07222): Proacrosin binding protein sp32
UBA (PF00627): UBA/TS-N domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhE (PF04216): Protein involved in formate dehydrogenase formation
WWE (PF02825): WWE domain
BSP_II (PF05432): Bone sialoprotein II (BSP-II)
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
Nop14 (PF04147): Nop14-like family
DUF4414 (PF14377): Domain of unknown function (DUF4414)
Mucin (PF01456): Mucin-like glycoprotein
BUD22 (PF09073): BUD22
HABP4_PAI-RBP1 (PF04774): Hyaluronan / mRNA binding family
HECT (PF00632): HECT-domain (ubiquitin-transferase)
LOC103728661
interactor100CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
LOC103750102
interactor200BPL_LplA_LipB (PF03099): Biotin/lipoate A/B protein ligase family
BPL_C (PF02237): Biotin protein ligase C terminal domain
Nanog
interactor40.6670.667Homeobox (PF00046): Homeobox domain
Pcgf1
interactor50.5002.667zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Pou5f1
oncogene21.0000Pou (PF00157): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046): Homeobox domain
Pten
oncogene, tumor suppressor31.0000DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
Rgs1
oncogene100RGS (PF00615): Regulator of G protein signaling domain

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