Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acaca (from a repository: Tue Oct 20 09:27:26 2020)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins14 (20.90 %)
The number (and %) of the tumor suppressors11 (16.42 %)
Total number of binary PPIs (saturation %)304 (13.75 %)
The number (and %) of affected PPIs66 (21.71 %)
PPI diameter2
PPI radius1
The average degree of PPI8.209
Assortativity coefficient-0.3315
The network average Clustering coefficient0.531
The number (and %) of a zero Clustering coefficients5 (7.46 %)
The number (and %) of a zero Betweenness Centrality14 (20.90 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acaca
user protein660.0972899.434Biotin_carb_N (PF00289): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786): Carbamoyl-phosphate synthase L chain, ATP binding domain
Biotin_carb_C (PF02785): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364): Biotin-requiring enzyme
ACC_central (PF08326): Acetyl-CoA carboxylase, central region
Carboxyl_trans (PF01039): Carboxyl transferase domain
DUF445 (PF04286): Protein of unknown function (DUF445)
Akr1b10
interactor31.0000Aldo_ket_red (PF00248): Aldo/keto reductase family
Ap2m1
interactor60.6001.467Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain
Adap_comp_sub (PF00928): Adaptor complexes medium subunit family
Arhgap25
oncogene100PH (PF00169): PH domain
RhoGAP (PF00620): RhoGAP domain
ADIP (PF11559): Afadin- and alpha -actinin-Binding
Arrb1
interactor50.6002.667Arrestin_N (PF00339): Arrestin (or S-antigen), N-terminal domain
Arrestin_C (PF02752): Arrestin (or S-antigen), C-terminal domain
Atxn1
interactor31.0000ATXN-1_C (PF12547): Capicua transcriptional repressor modulator
AXH (PF08517): Ataxin-1 and HBP1 module (AXH)
Bmi1
oncogene90.39312.400zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Brca1
oncogene, tumor suppressor80.4298.071zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
S36_mt (PF10937): Ribosomal protein S36, mitochondrial
BRCT_assoc (PF12820): Serine-rich domain associated with BRCT
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Cbl
oncogene, tumor suppressor90.7504.400Cbl_N (PF02262): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
UBA (PF00627): UBA/TS-N domain
Cct3
interactor140.36334.360Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family
Chgb
interactor21.0000Granin (PF01271): Granin (chromogranin or secretogranin)
Copb1
interactor110.5119.629Adaptin_N (PF01602): Adaptin N terminal region
Coatamer_beta_C (PF07718): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806): Coatomer beta subunit appendage platform
Coq9
interactor200COQ9 (PF08511): COQ9
Csnk1a1
oncogene, tumor suppressor60.6002.286Pkinase (PF00069): Protein kinase domain
Csnk1e
interactor50.6672.000Pkinase (PF00069): Protein kinase domain
APH (PF01636): Phosphotransferase enzyme family
Eef2k
interactor21.0000Alpha_kinase (PF02816): Alpha-kinase family
Sel1 (PF08238): Sel1 repeat
DUF1771 (PF08590): Domain of unknown function (DUF1771)
Elp1
interactor41.0000IKI3 (PF04762): IKI3 family
Clathrin (PF00637): Region in Clathrin and VPS
Epb41l1
interactor50.6003.000FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
FA (PF08736): FERM adjacent (FA)
SAB (PF04382): SAB domain
G6B (PF15096): G6B family
4_1_CTD (PF05902): 4.1 protein C-terminal domain (CTD)
Ercc6l
interactor21.0000TPR_2 (PF07719): Tetratricopeptide repeat
SNF2_N (PF00176): SNF2 family N-terminal domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
TPR_11 (PF13414): TPR repeat
Fn1
oncogene160.29253.882fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Fus
oncogene, tumor suppressor130.46224.033Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Grk2
interactor40.6671.167RGS (PF00615): Regulator of G protein signaling domain
Pkinase (PF00069): Protein kinase domain
PH (PF00169): PH domain
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Iars
interactor80.4296.109tRNA-synt_1 (PF00133): tRNA synthetases class I (I, L, M and V)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
Ilk
tumor suppressor100.38912.533Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Inppl1
oncogene100.57811.938SH2 (PF00017): SH2 domain
Exo_endo_phos (PF03372): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Kif5b
interactor60.5333.956Kinesin (PF00225): Kinesin motor domain
PRKG1_interact (PF15898): cGMP-dependent protein kinase interacting domain
DUF3584 (PF12128): Protein of unknown function (DUF3584)
XhlA (PF10779): Haemolysin XhlA
Med9 (PF07544): RNA polymerase II transcription mediator complex subunit 9
HAUS-augmin3 (PF14932): HAUS augmin-like complex subunit 3
DUF4226 (PF10774): Domain of unknown function (DUF4226)
Sec2p (PF06428): GDP/GTP exchange factor Sec2p
LOC103732255
interactor90.5568.737Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain
LOC103732819
interactor100.37811.448F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region
LOC103748852
interactor220.257114.040Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Lgals3bp
oncogene50.6670.515SRCR (PF00530): Scavenger receptor cysteine-rich domain
BACK (PF07707): BTB And C-terminal Kelch
VRP1 (PF03538): Salmonella virulence plasmid 28.1kDa A protein
Liph
interactor100Lipase (PF00151): Lipase
Mdm2
oncogene150.26449.721SWIB (PF02201): SWIB/MDM2 domain
Presenilin (PF01080): Presenilin
DUF4194 (PF13835): Domain of unknown function (DUF4194)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-FPG_IleRS (PF06827): Zinc finger found in FPG and IleRS
Mllt1
oncogene50.7002.067YEATS (PF03366): YEATS family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Peptidase_S64 (PF08192): Peptidase family S64
BET (PF17035): Bromodomain extra-terminal - transcription regulation
Mllt3
oncogene40.8330.400YEATS (PF03366): YEATS family
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
DUF3446 (PF11928): Domain of unknown function (DUF3446)
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
BET (PF17035): Bromodomain extra-terminal - transcription regulation
Mov10
interactor90.36114.389AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
Ndufa4
interactor60.5003.667B12D (PF06522): NADH-ubiquinone reductase complex 1 MLRQ subunit
Npm1
tumor suppressor170.37543.144Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285): SDA1
NPM1-C (PF16276): Nucleophosmin C-terminal domain
Ntrk1
oncogene280.197221.198LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nup50
interactor60.6004.067NUP50 (PF08911): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638): RanBP1 domain
Nxf1
interactor120.34520.469Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Phkg2
interactor60.6674.167Pkinase (PF00069): Protein kinase domain
APH (PF01636): Phosphotransferase enzyme family
Pik3r2
oncogene130.42328.775SH3_9 (PF14604): Variant SH3 domain
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Ppp4r3a
interactor30.6670.667WH1 (PF00568): WH1 domain
SMK-1 (PF04802): Component of IIS longevity pathway SMK-1
Collagen (PF01391): Collagen triple helix repeat (20 copies)
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
Prkaa1
tumor suppressor90.52811.889Pkinase (PF00069): Protein kinase domain
AdenylateSensor (PF16579): Adenylate sensor of SNF1-like protein kinase
Prkaa2
tumor suppressor50.7002.333Pkinase (PF00069): Protein kinase domain
AdenylateSensor (PF16579): Adenylate sensor of SNF1-like protein kinase
Prkab1
interactor, oncogene50.9000.500AMPK1_CBM (PF16561): Glycogen recognition site of AMP-activated protein kinase
AMPKBI (PF04739): 5'-AMP-activated protein kinase beta subunit, interaction domain
Prkag1
interactor70.6673.722CBS (PF00571): CBS domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Psmb2
interactor60.6004.833Proteasome (PF00227): Proteasome subunit
Psmb7
interactor80.4768.233Proteasome (PF00227): Proteasome subunit
Pr_beta_C (PF12465): Proteasome beta subunits C terminal
Psmc6
interactor90.4647.309TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450): Proteasomal ATPase OB/ID domain
AAA_2 (PF07724): AAA domain (Cdc48 subfamily)
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Psmd2
oncogene110.38219.660AAA_32 (PF13654): AAA domain
PC_rep (PF01851): Proteasome/cyclosome repeat
THAP (PF05485): THAP domain
HEAT_2 (PF13646): HEAT repeats
Pten
oncogene, tumor suppressor70.4008.500DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
Riok2
interactor21.0000Rio2_N (PF09202): Rio2, N-terminal
RIO1 (PF01163): RIO1 family
Milton (PF12448): Kinesin associated protein
Rnf2
interactor120.34525.886zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Rps6ka1
oncogene40.6672.000Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Sgcz
interactor100Sarcoglycan_1 (PF04790): Sarcoglycan complex subunit protein
Shc1
oncogene150.41832.719PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Sirt1
oncogene, tumor suppressor80.4299.619PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
DUF592 (PF04574): Protein of unknown function (DUF592)
SIR2 (PF02146): Sir2 family
TPP_enzyme_M (PF00205): Thiamine pyrophosphate enzyme, central domain
Sirt7
interactor120.43918.005DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Socs6
interactor31.0000SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Stk25
interactor100Pkinase (PF00069): Protein kinase domain
DUF1241 (PF06840): Protein of unknown function (DUF1241)
Stk3
interactor31.0000Pkinase (PF00069): Protein kinase domain
Selenoprotein_S (PF06936): Selenoprotein S (SelS)
Mst1_SARAH (PF11629): C terminal SARAH domain of Mst1
Suz12
oncogene, tumor suppressor100.4729.867Cloacin (PF03515): Colicin-like bacteriocin tRNase domain
VEFS-Box (PF09733): VEFS-Box of polycomb protein
DUF2070 (PF09843): Predicted membrane protein (DUF2070)
Ubash3b
interactor70.8001.186UBA (PF00627): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604): Variant SH3 domain
His_Phos_1 (PF00300): Histidine phosphatase superfamily (branch 1)
Ube2n
interactor50.5001.086UQ_con (PF00179): Ubiquitin-conjugating enzyme
Vcp
interactor190.31475.067CDC48_N (PF02359): Cell division protein 48 (CDC48), N-terminal domain
CDC48_2 (PF02933): Cell division protein 48 (CDC48), domain 2
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
TniB (PF05621): Bacterial TniB protein
Vps4_C (PF09336): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099): Domain of unknown function (DUF3944)
Znf746
interactor90.3218.786DUF3669 (PF12417): Zinc finger protein
KRAB (PF01352): KRAB box
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Period_C (PF12114): Period protein 2/3C-terminal region
zf-C2H2_11 (PF16622): zinc-finger C2H2-type

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