Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acaa2 (from a repository: Fri Apr 13 08:23:38 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins8 (14.81 %)
The number (and %) of the tumor suppressors4 (7.41 %)
Total number of binary PPIs (saturation %)249 (17.40 %)
The number (and %) of affected PPIs53 (21.29 %)
PPI diameter2
PPI radius1
The average degree of PPI8.593
Assortativity coefficient-0.3659
The network average Clustering coefficient0.609
The number (and %) of a zero Clustering coefficients4 (7.41 %)
The number (and %) of a zero Betweenness Centrality15 (27.78 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acaa2
user protein530.1301735.604Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Acat1
interactor80.5246.786Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Aco2
interactor60.6003.452Aconitase (PF00330): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694): Aconitase C-terminal domain
Ak2
interactor21.0000ADK (PF00406): Adenylate kinase
Aminotran_3 (PF00202): Aminotransferase class-III
Aldoa
interactor160.49527.047Glycolytic (PF00274): Fructose-bisphosphate aldolase class-I
App
interactor100.41712.569APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Armc6
interactor100Mis14 (PF08641): Kinetochore protein Mis14 like
Arm (PF00514): Armadillo/beta-catenin-like repeat
HEAT_EZ (PF13513): HEAT-like repeat
Atx10homo_assoc (PF09759): Spinocerebellar ataxia type 10 protein domain
CRS1_YhbY (PF01985): CRS1 / YhbY (CRM) domain
Atp1b1
interactor90.5289.667Na_K-ATPase (PF00287): Sodium / potassium ATPase beta chain
Atp1b3
interactor80.5007.267Na_K-ATPase (PF00287): Sodium / potassium ATPase beta chain
Cfl1
interactor140.45130.389Cofilin_ADF (PF00241): Cofilin/tropomyosin-type actin-binding protein
Chat
interactor100Carn_acyltransf (PF00755): Choline/Carnitine o-acyltransferase
Csrp1
interactor41.0000LIM (PF00412): LIM domain
zf-MYND (PF01753): MYND finger
Ewsr1
oncogene120.45522.373Keratin_2_head (PF16208): Keratin type II head
SVS_QK (PF10578): Seminal vesicle protein repeat
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Ezr
interactor140.7057.343FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
EIIBC-GUT_N (PF03612): Sorbitol phosphotransferase enzyme II N-terminus
ERM (PF00769): Ezrin/radixin/moesin family
Fkbp2
interactor80.6796.819FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
Hnrnpa1
interactor160.42936.775RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627): Nuclear factor hnRNPA1
Hnrnpa2b1
oncogene70.7142.626RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Hsd17b10
interactor210.40573.450adh_short (PF00106): short chain dehydrogenase
Hspb2
heat shock41.0000Crystallin (PF00525): Alpha crystallin A chain, N terminal
HSP20 (PF00011): Hsp20/alpha crystallin family
Isyna1
interactor90.7223.207NAD_binding_5 (PF07994): Myo-inositol-1-phosphate synthase
LOC103732255
interactor210.41977.187Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain
LOC103746136
interactor190.38657.035Histone (PF00125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211): C-terminus of histone H2A
DUF1764 (PF08576): Eukaryotic protein of unknown function (DUF1764)
Macro (PF01661): Macro domain
Msn
oncogene160.54321.399FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
DUF883 (PF05957): Bacterial protein of unknown function (DUF883)
ERM (PF00769): Ezrin/radixin/moesin family
Mtif2
interactor21.0000GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4
Dynamin_N (PF00350): Dynamin family
IF-2 (PF11987): Translation-initiation factor 2
Ntrk1
oncogene250.283141.056LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
P4hb
interactor100.7563.859Thioredoxin (PF00085): Thioredoxin
AhpC-TSA (PF00578): AhpC/TSA family
Thioredoxin_6 (PF13848): Thioredoxin-like domain
Pfn1
oncogene, tumor suppressor41.0000Profilin (PF00235): Profilin
Pgd
oncogene70.7621.733NAD_binding_2 (PF03446): NAD binding domain of 6-phosphogluconate dehydrogenase
6PGD (PF00393): 6-phosphogluconate dehydrogenase, C-terminal domain
Pgk1
interactor120.6915.770PGK (PF00162): Phosphoglycerate kinase
Pofut1
interactor31.0000O-FucT (PF10250): GDP-fucose protein O-fucosyltransferase
Prdx1
oncogene70.7332.389AhpC-TSA (PF00578): AhpC/TSA family
1-cysPrx_C (PF10417): C-terminal domain of 1-Cys peroxiredoxin
Prepl
interactor100DUF4358 (PF14270): Domain of unknown function (DUF4358)
Peptidase_S9_N (PF02897): Prolyl oligopeptidase, N-terminal beta-propeller domain
Peptidase_S9 (PF00326): Prolyl oligopeptidase family
Rdx
interactor110.7274.856FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
ERM (PF00769): Ezrin/radixin/moesin family
Rtn4
oncogene, tumor suppressor80.5246.486CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Reticulon (PF02453): Reticulon
Sf3b4
interactor30.6670.667RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Sgta
interactor100SGTA_dimer (PF16546): Homodimerisation domain of SGTA
TPR_11 (PF13414): TPR repeat
TPR_1 (PF00515): Tetratricopeptide repeat
TOM20_plant (PF06552): Plant specific mitochondrial import receptor subunit TOM20
XPC-binding (PF09280): XPC-binding domain
Sh3pxd2b
interactor21.0000PX (PF00787): PX domain
SH3_1 (PF00018): SH3 domain
SH3_2 (PF07653): Variant SH3 domain
Taf15
oncogene31.0000Presenilin (PF01080): Presenilin
API5 (PF05918): Apoptosis inhibitory protein 5 (API5)
Keratin_2_head (PF16208): Keratin type II head
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
GRP (PF07172): Glycine rich protein family
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Tagln
oncogene, tumor suppressor80.6434.719Calponin (PF00402): Calponin family repeat
CH (PF00307): Calponin homology (CH) domain
Tagln2
interactor140.53819.598CH (PF00307): Calponin homology (CH) domain
Calponin (PF00402): Calponin family repeat
Tax1bp3
interactor40.5003.000GRASP55_65 (PF04495): GRASP55/65 PDZ-like domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Tert
oncogene21.0000Telomerase_RBD (PF12009): Telomerase ribonucleoprotein complex - RNA binding domain
RVT_1 (PF00078): Reverse transcriptase (RNA-dependent DNA polymerase)
Tial1
interactor40.6671.667RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Calcipressin (PF04847): Calcipressin
PHM7_cyt (PF14703): Cytosolic domain of 10TM putative phosphate transporter
Tkt
interactor150.58221.603Transketolase_N (PF00456): Transketolase, thiamine diphosphate binding domain
Transket_pyr (PF02779): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780): Transketolase, C-terminal domain
Tmem65
interactor40.5002.400TMEM65 (PF10507): Transmembrane protein 65
Tomm40
interactor90.44415.633Porin_3 (PF01459): Eukaryotic porin
Tp53bp1
oncogene, tumor suppressor31.0000DUF2052 (PF09747): Coiled-coil domain containing protein (DUF2052)
53-BP1_Tudor (PF09038): Tumour suppressor p53-binding protein-1 Tudor
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
Trmt61b
interactor21.0000GCD14 (PF08704): tRNA methyltransferase complex GCD14 subunit
Methyltransf_25 (PF13649): Methyltransferase domain
Uchl3
interactor120.7275.045Peptidase_C12 (PF01088): Ubiquitin carboxyl-terminal hydrolase, family 1
DUF935 (PF06074): Protein of unknown function (DUF935)
Usp8
interactor40.6670.154USP8_dimer (PF08969): USP8 dimerisation domain
DUF2052 (PF09747): Coiled-coil domain containing protein (DUF2052)
Rhodanese (PF00581): Rhodanese-like domain
MAP7 (PF05672): MAP7 (E-MAP-115) family
SET (PF00856): SET domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
Vamp2
interactor30.6671.000PRIMA1 (PF16101): Proline-rich membrane anchor 1
Synaptobrevin (PF00957): Synaptobrevin
Vdac1
interactor80.5716.852Porin_3 (PF01459): Eukaryotic porin
Vdac2
interactor70.4767.352Porin_3 (PF01459): Eukaryotic porin
Zfr
interactor40.6671.167Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
zf-met (PF12874): Zinc-finger of C2H2 type
ANAPC_CDC26 (PF10471): Anaphase-promoting complex APC subunit CDC26
DZF (PF07528): DZF domain

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