Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abraxas2 (from a repository: Fri Apr 13 19:35:03 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins9 (27.27 %)
The number (and %) of the tumor suppressors3 (9.09 %)
Total number of binary PPIs (saturation %)114 (21.59 %)
The number (and %) of affected PPIs32 (28.07 %)
PPI diameter2
PPI radius1
The average degree of PPI6.061
Assortativity coefficient-0.4469
The network average Clustering coefficient0.588
The number (and %) of a zero Clustering coefficients5 (15.15 %)
The number (and %) of a zero Betweenness Centrality13 (39.39 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abraxas2
user protein320.137666.450JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Cluap1 (PF10234): Clusterin-associated protein-1
Ankrd28
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Arrdc1
interactor30.6671.000Arrestin_N (PF00339): Arrestin (or S-antigen), N-terminal domain
Arrestin_C (PF02752): Arrestin (or S-antigen), C-terminal domain
Aup1
interactor21.0000CUE (PF02845): CUE domain
Babam1
interactor90.6117.433MPP6 (PF10175): M-phase phosphoprotein 6
VWA_2 (PF13519): von Willebrand factor type A domain
Babam2
oncogene110.56412.367BRE (PF06113): Brain and reproductive organ-expressed protein (BRE)
Birc6
oncogene51.0000BIR (PF00653): Inhibitor of Apoptosis domain
ABC_tran_CTD (PF16326): ABC transporter C-terminal domain
DUF3573 (PF12097): Protein of unknown function (DUF3573)
BIRC6 (PF12356): Baculoviral IAP repeat-containing protein 6
UQ_con (PF00179): Ubiquitin-conjugating enzyme
Brcc3
interactor140.47426.483JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Elavl1
oncogene70.4676.333RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fam19a4
interactor100TAFA (PF12020): TAFA family
Grb2
oncogene80.7143.500SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Hnrnpa2b1
oncogene70.7142.583RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Huwe1
oncogene120.40023.100DUF908 (PF06012): Domain of Unknown Function (DUF908)
DUF913 (PF06025): Domain of Unknown Function (DUF913)
PBP_sp32 (PF07222): Proacrosin binding protein sp32
UBA (PF00627): UBA/TS-N domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhE (PF04216): Protein involved in formate dehydrogenase formation
WWE (PF02825): WWE domain
BSP_II (PF05432): Bone sialoprotein II (BSP-II)
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
Nop14 (PF04147): Nop14-like family
DUF4414 (PF14377): Domain of unknown function (DUF4414)
Mucin (PF01456): Mucin-like glycoprotein
BUD22 (PF09073): BUD22
HABP4_PAI-RBP1 (PF04774): Hyaluronan / mRNA binding family
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Klhl10
oncogene100BTB (PF00651): BTB/POZ domain
BACK (PF07707): BTB And C-terminal Kelch
Kelch_1 (PF01344): Kelch motif
Lamc1
interactor30.6670.667Laminin_N (PF00055): Laminin N-terminal (Domain VI)
Laminin_EGF (PF00053): Laminin EGF domain
Laminin_B (PF00052): Laminin B (Domain IV)
LOH1CR12 (PF10158): Tumour suppressor protein
Phage_holin_6_1 (PF09682): Bacteriophage holin of superfamily 6 (Holin_LLH)
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
DUF4600 (PF15372): Domain of unknown function (DUF4600)
Laminin_II (PF06009): Laminin Domain II
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
FlaC_arch (PF05377): Flagella accessory protein C (FlaC)
Psmc5
interactor80.5249.167RILP (PF11461): Rab interacting lysosomal protein
Laminin_II (PF06009): Laminin Domain II
AAA_16 (PF13191): AAA ATPase domain
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Shmt2
interactor50.8000.583SHMT (PF00464): Serine hydroxymethyltransferase
Smurf2
interactor40.6670.667C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Spag9
interactor31.0000Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
DUF501 (PF04417): Protein of unknown function (DUF501)
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF972 (PF06156): Protein of unknown function (DUF972)
ERM (PF00769): Ezrin/radixin/moesin family
TACC (PF05010): Transforming acidic coiled-coil-containing protein (TACC)
IncA (PF04156): IncA protein
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
FYDLN_acid (PF09538): Protein of unknown function (FYDLN_acid)
Stk11
oncogene, tumor suppressor21.0000Pkinase (PF00069): Protein kinase domain
Suv39h1
interactor31.0000Chromo (PF00385): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033): Pre-SET motif
SET (PF00856): SET domain
Thap11
interactor31.0000THAP (PF05485): THAP domain
DUF2722 (PF10846): Protein of unknown function (DUF2722)
MRP-S31 (PF15433): Mitochondrial 28S ribosomal protein S31
Thap5
interactor100THAP (PF05485): THAP domain
Tns1
interactor40.8330.400C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
SH2 (PF00017): SH2 domain
PTB (PF08416): Phosphotyrosine-binding domain
Tns2
interactor80.38110.750C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
cEGF (PF12662): Complement Clr-like EGF-like
SH2 (PF00017): SH2 domain
PTB (PF08416): Phosphotyrosine-binding domain
Tp53
tumor suppressor130.45525.650P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif
Traf7
oncogene21.0000zf-RING_UBOX (PF13445): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Sina (PF03145): Seven in absentia protein family
zf-TRAF (PF02176): TRAF-type zinc finger
PKcGMP_CC (PF16808): Coiled-coil N-terminus of cGMP-dependent protein kinase
DUF4164 (PF13747): Domain of unknown function (DUF4164)
WD40 (PF00400): WD domain, G-beta repeat
WD40_like (PF17005): WD40-like domain
Ubc
interactor160.40047.417ubiquitin (PF00240): Ubiquitin family
Uimc1
tumor suppressor41.0000UIM (PF02809): Ubiquitin interaction motif
Nbs1_C (PF08599): DNA damage repair protein Nbs1
MMADHC (PF10229): Methylmalonic aciduria and homocystinuria type D protein
Rad50_zn_hook (PF04423): Rad50 zinc hook motif
Usp7
oncogene90.7862.283MATH (PF00917): MATH domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
USP7_C2 (PF14533): Ubiquitin-specific protease C-terminal
USP7_ICP0_bdg (PF12436): ICP0-binding domain of Ubiquitin-specific protease 7
Wwp2
interactor70.7334.000WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Xkrx
interactor100XK-related (PF09815): XK-related protein
Xpo1
interactor50.4005.167IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal

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