Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Ablim1 (from a repository: Mon Apr 16 01:28:34 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins8 (14.55 %)
The number (and %) of the tumor suppressors6 (10.91 %)
Total number of binary PPIs (saturation %)217 (14.61 %)
The number (and %) of affected PPIs54 (24.88 %)
PPI diameter2
PPI radius1
The average degree of PPI7.236
Assortativity coefficient-0.3267
The network average Clustering coefficient0.578
The number (and %) of a zero Clustering coefficients7 (12.73 %)
The number (and %) of a zero Betweenness Centrality17 (30.91 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Ablim1
user protein540.1012192.481zf-HYPF (PF07503): HypF finger
LIM (PF00412): LIM domain
zf-dskA_traR (PF01258): Prokaryotic dksA/traR C4-type zinc finger
P12 (PF12669): Virus attachment protein p12 family
DUF2175 (PF09943): Uncharacterized protein conserved in archaea (DUF2175)
AbLIM_anchor (PF16182): Putative adherens-junction anchoring region of AbLIM
VHP (PF02209): Villin headpiece domain
Abce1
interactor90.42912.233RLI (PF04068): Possible Fer4-like domain in RNase L inhibitor, RLI
Fer4 (PF00037): 4Fe-4S binding domain
Fer4_7 (PF12838): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
Abra
interactor100DUF4632 (PF15451): Domain of unknown function (DUF4632)
Costars (PF14705): Costars
Actb
oncogene81.0000Actin (PF00022): Actin
Anln
oncogene91.0000Anillin_N (PF16018): Anillin N-terminus
Anillin (PF08174): Cell division protein anillin
PH (PF00169): PH domain
App
interactor90.35715.167APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Asb18
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
SOCS_box (PF07525): SOCS box
Bco1
interactor100RPE65 (PF03055): Retinal pigment epithelial membrane protein
Begain
interactor40.6670.500Rab5-bind (PF09311): Rabaptin-like protein
Uso1_p115_C (PF04871): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF4472 (PF14739): Domain of unknown function (DUF4472)
Calcoco2
interactor41.0000CALCOCO1 (PF07888): Calcium binding and coiled-coil domain (CALCOCO1) like
bZIP_1 (PF00170): bZIP transcription factor
DUF641 (PF04859): Plant protein of unknown function (DUF641)
YlqD (PF11068): YlqD protein
HALZ (PF02183): Homeobox associated leucine zipper
Capza2
interactor130.75612.857F-actin_cap_A (PF01267): F-actin capping protein alpha subunit
Card9
interactor200CARD (PF00619): Caspase recruitment domain
APG6 (PF04111): Autophagy protein Apg6
DUF972 (PF06156): Protein of unknown function (DUF972)
HALZ (PF02183): Homeobox associated leucine zipper
ADIP (PF11559): Afadin- and alpha -actinin-Binding
Cask
interactor40.6672.000Pkinase (PF00069): Protein kinase domain
L27 (PF02828): L27 domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653): Variant SH3 domain
Guanylate_kin (PF00625): Guanylate kinase
Ccdc8
interactor31.0000PNMA (PF14893): PNMA
Cdh1
oncogene, tumor suppressor50.7002.667Cadherin (PF00028): Cadherin domain
Cadherin_C (PF01049): Cadherin cytoplasmic region
Cenpj
interactor80.39316.067CorA (PF01544): CorA-like Mg2+ transporter protein
Rota_VP2 (PF05087): Rotavirus VP2 protein
DUF4972 (PF16342): Domain of unknown function (DUF4972)
DUF848 (PF05852): Gammaherpesvirus protein of unknown function (DUF848)
Tho2 (PF11262): Transcription factor/nuclear export subunit protein 2
IncA (PF04156): IncA protein
Tcp10_C (PF07202): T-complex protein 10 C-terminus
Cep128
interactor80.42913.167DUF2120 (PF09893): Uncharacterized protein conserved in archaea (DUF2120)
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Fib_alpha (PF08702): Fibrinogen alpha/beta chain family
DUF1664 (PF07889): Protein of unknown function (DUF1664)
AATF-Che1 (PF13339): Apoptosis antagonizing transcription factor
DUF948 (PF06103): Bacterial protein of unknown function (DUF948)
DUF2968 (PF11180): Protein of unknown function (DUF2968)
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Pinin_SDK_memA (PF04696): pinin/SDK/memA/ protein conserved region
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
Cep19
interactor30.6671.000CEP19 (PF14933): CEP19-like protein
Cep89
interactor60.5336.000DUF4407 (PF14362): Domain of unknown function (DUF4407)
DUF1313 (PF07011): Protein of unknown function (DUF1313)
TolA_bind_tri (PF16331): TolA binding protein trimerisation
HemX (PF04375): HemX, putative uroporphyrinogen-III C-methyltransferase
CorA (PF01544): CorA-like Mg2+ transporter protein
Dbn1
oncogene110.8184.157Cofilin_ADF (PF00241): Cofilin/tropomyosin-type actin-binding protein
CRT10 (PF08728): CRT10
PNISR (PF15996): Arginine/serine-rich protein PNISR
BORG_CEP (PF14957): Cdc42 effector
Pinin_SDK_memA (PF04696): pinin/SDK/memA/ protein conserved region
Fbf1
interactor80.28618.000KfrA_N (PF11740): Plasmid replication region DNA-binding N-term
XhlA (PF10779): Haemolysin XhlA
DUF106 (PF01956): Integral membrane protein DUF106
Thioredoxin_4 (PF13462): Thioredoxin
DUF3450 (PF11932): Protein of unknown function (DUF3450)
IFT20 (PF14931): Intraflagellar transport complex B, subunit 20
Spc24 (PF08286): Spc24 subunit of Ndc80
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Flna
tumor suppressor160.61723.914CH (PF00307): Calponin homology (CH) domain
Filamin (PF00630): Filamin/ABP280 repeat
Hook2
interactor31.0000HOOK (PF05622): HOOK protein
Iqgap1
interactor120.7279.257CH (PF00307): Calponin homology (CH) domain
WW (PF00397): WW domain
IQ (PF00612): IQ calmodulin-binding motif
RasGAP (PF00616): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836): RasGAP C-terminus
Kiaa0753
interactor70.5248.333MNR (PF15718): Protein moonraker
DUF4337 (PF14235): Domain of unknown function (DUF4337)
Klhl40
interactor100BTB (PF00651): BTB/POZ domain
BACK (PF07707): BTB And C-terminal Kelch
Kelch_6 (PF13964): Kelch motif
Kelch_1 (PF01344): Kelch motif
Krt15
interactor30.6671.000Keratin_2_head (PF16208): Keratin type II head
Filament (PF00038): Intermediate filament protein
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
LOC103724820
interactor31.0000IRK_N (PF08466): Inward rectifier potassium channel N-terminal
IRK (PF01007): Inward rectifier potassium channel
LOC103727574
interactor40.5002.667Atg14 (PF10186): Vacuolar sorting 38 and autophagy-related subunit 14
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
DUF2046 (PF09755): Uncharacterized conserved protein H4 (DUF2046)
BRE1 (PF08647): BRE1 E3 ubiquitin ligase
FliJ (PF02050): Flagellar FliJ protein
GOLGA2L5 (PF15070): Putative golgin subfamily A member 2-like protein 5
Ldoc1
oncogene31.0000DUF4939 (PF16297): Domain of unknown function (DUF4939)
Lin7c
interactor50.5004.667L27 (PF02828): L27 domain
His_Phos_2 (PF00328): Histidine phosphatase superfamily (branch 2)
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Mapre1
oncogene100.41716.133CH (PF00307): Calponin homology (CH) domain
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
EB1 (PF03271): EB1-like C-terminal motif
Med21
interactor200Med21 (PF11221): Subunit 21 of Mediator complex
Myh9
oncogene, tumor suppressor160.58332.548Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Myo18a
interactor120.8792.190Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
DUF2570 (PF10828): Protein of unknown function (DUF2570)
ERM (PF00769): Ezrin/radixin/moesin family
Myo19
interactor110.9450.667XPC-binding (PF09280): XPC-binding domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myo1c
interactor130.75613.190Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_TH1 (PF06017): Unconventional myosin tail, actin- and lipid-binding
Ninl
interactor60.6673.500EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_1 (PF00036): EF hand
Spc7 (PF08317): Spc7 kinetochore protein
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
GAS (PF13851): Growth-arrest specific micro-tubule binding
Filament (PF00038): Intermediate filament protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
YlqD (PF11068): YlqD protein
Uso1_p115_C (PF04871): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2968 (PF11180): Protein of unknown function (DUF2968)
ZapB (PF06005): Cell division protein ZapB
ADIP (PF11559): Afadin- and alpha -actinin-Binding
Calc_CGRP_IAPP (PF00214): Calcitonin / CGRP / IAPP family
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Nmt1
oncogene60.3339.333NST1 (PF13945): Salt tolerance down-regulator
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
NMT (PF01233): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Odf2
interactor40.6671.667CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
COMMD1_N (PF17221): COMMD1 N-terminal domain
Invasin_D3 (PF09134): Invasin, domain 3
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Mt_ATP-synt_D (PF05873): ATP synthase D chain, mitochondrial (ATP5H)
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Pdlim7
interactor120.45529.167PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936): Domain of unknown function (DUF4749)
zinc_ribbon_10 (PF10058): Predicted integral membrane zinc-ribbon metal-binding protein
LIM (PF00412): LIM domain
Ppp1cb
interactor130.7826.924STPPase_N (PF16891): Serine-threonine protein phosphatase N-terminal domain
Metallophos (PF00149): Calcineurin-like phosphoesterase
Sepsecs
interactor21.0000SepSecS (PF05889): O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
Sfn
tumor suppressor41.000014-3-3 (PF00244): 14-3-3 protein
Srebf2
interactor200TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
HLH (PF00010): Helix-loop-helix DNA-binding domain
Stil
oncogene30.6671.000STIL_N (PF15253): SCL-interrupting locus protein N-terminus
Suz12
oncogene, tumor suppressor31.0000Cloacin (PF03515): Colicin-like bacteriocin tRNase domain
VEFS-Box (PF09733): VEFS-Box of polycomb protein
DUF2070 (PF09843): Predicted membrane protein (DUF2070)
Synpo
interactor150.66716.014CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Calsarcin (PF05556): Calcineurin-binding protein (Calsarcin)
Traf2
interactor70.5335.833zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
Fer4_3 (PF12798): 4Fe-4S binding domain
zf-C3HC4_5 (PF17121): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673): TNF receptor-associated factor BIRC3 binding domain
DUF1664 (PF07889): Protein of unknown function (DUF1664)
MATH (PF00917): MATH domain
Ushbp1
interactor50.5002.667DUF2205 (PF10224): Predicted coiled-coil protein (DUF2205)
CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
MCC-bdg_PDZ (PF10506): PDZ domain of MCC-2 bdg protein for Usher syndrome
DUF4404 (PF14357): Domain of unknown function (DUF4404)
MscS_porin (PF12795): Mechanosensitive ion channel porin domain
Cep57_MT_bd (PF06657): Centrosome microtubule-binding domain of Cep57
Vim
tumor suppressor70.5335.233Filament_head (PF04732): Intermediate filament head (DNA binding) region
Filament (PF00038): Intermediate filament protein
Xpo1
interactor120.21248.400IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Ywhab
interactor60.6673.333Virulence_fact (PF13769): Virulence factor
14-3-3 (PF00244): 14-3-3 protein
Ywhae
oncogene50.8001.16714-3-3 (PF00244): 14-3-3 protein
Ywhaz
interactor120.38226.90014-3-3 (PF00244): 14-3-3 protein

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