Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abl2 (from a repository: Fri Apr 13 21:05:16 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins14 (38.89 %)
The number (and %) of the tumor suppressors7 (19.44 %)
Total number of binary PPIs (saturation %)167 (26.51 %)
The number (and %) of affected PPIs36 (21.56 %)
PPI diameter2
PPI radius1
The average degree of PPI8.000
Assortativity coefficient-0.4173
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients5 (13.89 %)
The number (and %) of a zero Betweenness Centrality10 (27.78 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abl2
user protein, oncogene360.183639.550SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
RGS12_us1 (PF16613): Unstructured region of RGS12
F_actin_bind (PF08919): F-actin binding
Abi2
tumor suppressor50.6670.917ATP-synt_ab_Xtn (PF16886): ATPsynthase alpha/beta subunit N-term extension
Abi_HHR (PF07815): Abl-interactor HHR
NUDE_C (PF04880): NUDE protein, C-terminal conserved region
Axin_b-cat_bind (PF08833): Axin beta-catenin binding domain
TMEM171 (PF15471): Transmembrane protein family 171
SH3_9 (PF14604): Variant SH3 domain
Abl1
interactor, oncogene230.329103.779SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF4124 (PF13511): Domain of unknown function (DUF4124)
F_actin_bind (PF08919): F-actin binding
Bag5
interactor100BAG (PF02179): BAG domain
RRF (PF01765): Ribosome recycling factor
Cat
interactor, tumor suppressor41.0000Catalase (PF00199): Catalase
Catalase-rel (PF06628): Catalase-related immune-responsive
Cdc37
interactor80.7141.840CDC37_N (PF03234): Cdc37 N terminal kinase binding
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
Rho_Binding (PF08912): Rho Binding
CDC37_M (PF08565): Cdc37 Hsp90 binding domain
CDC37_C (PF08564): Cdc37 C terminal domain
Crk
oncogene120.59115.879SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
SH3_2 (PF07653): Variant SH3 domain
Dok1
tumor suppressor100.7223.158PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)
Ephb2
tumor suppressor41.0000Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Erbb2
oncogene150.53817.896Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Rifin_STEVOR (PF02009): Rifin/stevor family
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Erbb3
oncogene160.50524.802Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
SKG6 (PF08693): Transmembrane alpha-helix domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Erbb4
interactor, oncogene, tumor suppressor90.7502.328Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
DUF3951 (PF13131): Protein of unknown function (DUF3951)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Fbxo38
interactor100F-box (PF00646): F-box domain
Secretin_N_2 (PF07655): Secretin N-terminal domain
TFIIE-A_C (PF11521): C-terminal general transcription factor TFIIE alpha
Menin (PF05053): Menin
Gpx1
oncogene21.0000GSHPx (PF00255): Glutathione peroxidase
Grb2
oncogene150.57119.856SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Hck
oncogene100.48912.633SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Hras
oncogene21.0000Ras (PF00071): Ras family
Hspa8
heat shock, oncogene100.6447.327HSP70 (PF00012): Hsp70 protein
Hspbp1
interactor40.8330.333DUF4726 (PF15855): Domain of unknown function (DUF4726)
Fes1 (PF08609): Nucleotide exchange factor Fes1
HEAT_EZ (PF13513): HEAT-like repeat
Rcd1 (PF04078): Cell differentiation family, Rcd1-like
Arm (PF00514): Armadillo/beta-catenin-like repeat
Jak1
oncogene90.7142.975FERM_M (PF00373): FERM central domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
LOC103748852
interactor210.43752.294Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Map3k10
interactor200SH3_9 (PF14604): Variant SH3 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF3552 (PF12072): Domain of unknown function (DUF3552)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Mdm2
oncogene100.4728.017SWIB (PF02201): SWIB/MDM2 domain
Presenilin (PF01080): Presenilin
DUF4194 (PF13835): Domain of unknown function (DUF4194)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-FPG_IleRS (PF06827): Zinc finger found in FPG and IleRS
Med28
interactor40.6670.286Med28 (PF11594): Mediator complex subunit 28
Nck1
oncogene90.7223.110SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nck2
interactor90.5716.178SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nedd4l
oncogene, tumor suppressor50.8330.286C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ntrk1
oncogene140.39730.986LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Oip5
interactor100Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Pik3r3
interactor90.7223.575SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Psma7
interactor60.8000.622Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Rin1
interactor60.7334.000SH2 (PF00017): SH2 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VPS9 (PF02204): Vacuolar sorting protein 9 (VPS9) domain
RA (PF00788): Ras association (RalGDS/AF-6) domain
Sorbs2
interactor, oncogene60.7001.139Sorb (PF02208): Sorbin homologous domain
Dmrt1 (PF12374): Double-sex mab3 related transcription factor 1
SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
Stat3
oncogene, tumor suppressor90.5718.236STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain
Tpd52l1
interactor200GvpK (PF05121): Gas vesicle protein K
TPD52 (PF04201): Tumour protein D52 family
Binary_toxB (PF03495): Clostridial binary toxin B/anthrax toxin PA
Trip10
interactor21.0000FCH (PF00611): Fes/CIP4, and EFC/F-BAR homology domain
DUF481 (PF04338): Protein of unknown function, DUF481
DUF4140 (PF13600): N-terminal domain of unknown function (DUF4140)
ZapB (PF06005): Cell division protein ZapB
SH3_1 (PF00018): SH3 domain

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