Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abl1 (from a repository: Fri Apr 20 02:06:07 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)152
The number (and %) of the onco-proteins58 (38.16 %)
The number (and %) of the tumor suppressors26 (17.11 %)
Total number of binary PPIs (saturation %)1238 (10.79 %)
The number (and %) of affected PPIs152 (12.28 %)
PPI diameter2
PPI radius1
The average degree of PPI15.303
Assortativity coefficient-0.2715
The network average Clustering coefficient0.544
The number (and %) of a zero Clustering coefficients3 (1.97 %)
The number (and %) of a zero Betweenness Centrality16 (10.53 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abl1
user protein, oncogene1520.08912238.909SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF4124 (PF13511): Domain of unknown function (DUF4124)
F_actin_bind (PF08919): F-actin binding
Abi1
oncogene70.6195.500Acid_PPase (PF12689): Acid Phosphatase
Abi_HHR (PF07815): Abl-interactor HHR
Cytochrom_B558a (PF05038): Cytochrome Cytochrome b558 alpha-subunit
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VIR_N (PF15912): Virilizer, N-terminal
SH3_1 (PF00018): SH3 domain
Abi2
tumor suppressor60.7001.500ATP-synt_ab_Xtn (PF16886): ATPsynthase alpha/beta subunit N-term extension
Abi_HHR (PF07815): Abl-interactor HHR
NUDE_C (PF04880): NUDE protein, C-terminal conserved region
Axin_b-cat_bind (PF08833): Axin beta-catenin binding domain
TMEM171 (PF15471): Transmembrane protein family 171
SH3_9 (PF14604): Variant SH3 domain
Abl2
oncogene230.32990.145SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
RGS12_us1 (PF16613): Unstructured region of RGS12
F_actin_bind (PF08919): F-actin binding
Acta1
interactor120.45517.857Actin (PF00022): Actin
Ankra2
interactor21.0000Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF1296 (PF06972): Protein of unknown function (DUF1296)
Ap2a1
interactor120.6828.097Adaptin_N (PF01602): Adaptin N terminal region
HEAT_2 (PF13646): HEAT repeats
Alpha_adaptinC2 (PF02883): Adaptin C-terminal domain
Alpha_adaptin_C (PF02296): Alpha adaptin AP2, C-terminal domain
Ap2b1
interactor110.8551.438Adaptin_N (PF01602): Adaptin N terminal region
Alpha_adaptinC2 (PF02883): Adaptin C-terminal domain
B2-adapt-app_C (PF09066): Beta2-adaptin appendage, C-terminal sub-domain
Ap2m1
interactor170.53327.450Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain
Adap_comp_sub (PF00928): Adaptor complexes medium subunit family
Arhgap17
interactor90.6944.620BAR (PF03114): BAR domain
RhoGAP (PF00620): RhoGAP domain
FAP (PF07174): Fibronectin-attachment protein (FAP)
Atm
oncogene, tumor suppressor130.50013.262TAN (PF11640): Telomere-length maintenance and DNA damage repair
UvrD_C (PF13361): UvrD-like helicase C-terminal domain
HEAT (PF02985): HEAT repeat
FAT (PF02259): FAT domain
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase
FATC (PF02260): FATC domain
Atr
oncogene, tumor suppressor110.6007.628HEAT_EZ (PF13513): HEAT-like repeat
HEAT (PF02985): HEAT repeat
UME (PF08064): UME (NUC010) domain
V-ATPase_H_C (PF11698): V-ATPase subunit H
CLASP_N (PF12348): CLASP N terminal
SgrT (PF15894): Inhibitor of glucose uptake transporter SgrT
TPR_2 (PF07719): Tetratricopeptide repeat
FAT (PF02259): FAT domain
DUF4838 (PF16126): Domain of unknown function (DUF4838)
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase
FATC (PF02260): FATC domain
Bag1
oncogene80.6793.206Band_7_C (PF16200): C-terminal region of band_7
ubiquitin (PF00240): Ubiquitin family
Amidase (PF01425): Amidase
BAG (PF02179): BAG domain
DUF5082 (PF16888): Domain of unknown function (DUF5082)
Bcar1
oncogene180.45133.441SH3_1 (PF00018): SH3 domain
Extensin_2 (PF04554): Extensin-like region
Serine_rich (PF08824): Serine rich protein interaction domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)
Bcl2l1
oncogene60.6002.321BH4 (PF02180): Bcl-2 homology region 4
Bcl-2 (PF00452): Apoptosis regulator proteins, Bcl-2 family
Bcr
oncogene250.41367.657Bcr-Abl_Oligo (PF09036): Bcr-Abl oncoprotein oligomerisation domain
DUF4692 (PF15763): Domain of unknown function (DUF4692)
RhoGEF (PF00621): RhoGEF domain
Bmp2k
interactor50.8000.800Pkinase (PF00069): Protein kinase domain
PNRC (PF15365): Proline-rich nuclear receptor coactivator
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
eIF-3c_N (PF05470): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
BMP2K_C (PF15282): BMP-2-inducible protein kinase C-terminus
Brca1
oncogene, tumor suppressor320.237184.775zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
S36_mt (PF10937): Ribosomal protein S36, mitochondrial
BRCT_assoc (PF12820): Serine-rich domain associated with BRCT
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Cables2
interactor21.0000Cyclin_N (PF00134): Cyclin, N-terminal domain
Casp9
oncogene50.7002.167CARD (PF00619): Caspase recruitment domain
Peptidase_C14 (PF00656): Caspase domain
Cat
interactor, tumor suppressor50.8330.500Catalase (PF00199): Catalase
Catalase-rel (PF06628): Catalase-related immune-responsive
Cbl
oncogene, tumor suppressor460.306303.153Cbl_N (PF02262): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
UBA (PF00627): UBA/TS-N domain
Cblb
oncogene170.65811.612Cbl_N (PF02262): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
UBA (PF00627): UBA/TS-N domain
Ccnd2
oncogene31.0000Cyclin_N (PF00134): Cyclin, N-terminal domain
Cyclin_C (PF02984): Cyclin, C-terminal domain
Cdk1
oncogene130.56111.766Pkinase (PF00069): Protein kinase domain
Cdkn1a
oncogene, tumor suppressor150.43828.137CDI (PF02234): Cyclin-dependent kinase inhibitor
Ckap4
interactor90.4294.966RskA (PF10099): Anti-sigma-K factor rskA
DUF3450 (PF11932): Protein of unknown function (DUF3450)
XhlA (PF10779): Haemolysin XhlA
DUF2087 (PF09860): Uncharacterized protein conserved in bacteria (DUF2087)
IFP_35_N (PF07334): Interferon-induced 35 kDa protein (IFP 35) N-terminus
IncA (PF04156): IncA protein
TBPIP (PF07106): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
NPV_P10 (PF05531): Nucleopolyhedrovirus P10 protein
Creb1
oncogene90.5368.333DUF4988 (PF16378): Domain of unknown function
pKID (PF02173): pKID domain
bZIP_1 (PF00170): bZIP transcription factor
Crk
oncogene440.277325.001SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
SH3_2 (PF07653): Variant SH3 domain
Crkl
oncogene220.45547.000SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
SH3_2 (PF07653): Variant SH3 domain
Ctnnb1
oncogene210.37654.801Arm (PF00514): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
DUF3361 (PF11841): Domain of unknown function (DUF3361)
Ddb1
interactor160.42921.436MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
CPSF_A (PF03178): CPSF A subunit region
Ddx5
oncogene160.45724.783DEAD (PF00270): DEAD/DEAH box helicase
ResIII (PF04851): Type III restriction enzyme, res subunit
Helicase_C (PF00271): Helicase conserved C-terminal domain
P68HR (PF08061): P68HR (NUC004) repeat
Dok1
tumor suppressor180.60312.632PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)
Dok2
tumor suppressor90.7221.699PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)
Drg1
interactor70.4763.318MMR_HSR1 (PF01926): 50S ribosome-binding GTPase
MMR_HSR1_Xtn (PF16897): C-terminal region of MMR_HSR1 domain
TGS (PF02824): TGS domain
Eef1g
interactor110.6006.517GST_N (PF02798): Glutathione S-transferase, N-terminal domain
GST_C (PF00043): Glutathione S-transferase, C-terminal domain
EF1G (PF00647): Elongation factor 1 gamma, conserved domain
Eif2a
interactor40.8330.400eIF2A (PF08662): Eukaryotic translation initiation factor eIF2A
Bap31 (PF05529): B-cell receptor-associated protein 31-like
Epha3
oncogene, tumor suppressor41.0000Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
EGF_CA (PF07645): Calcium-binding EGF domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Ephb2
tumor suppressor70.6670.895Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Eps15
oncogene160.55222.214EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
IncA (PF04156): IncA protein
Occludin_ELL (PF07303): Occludin homology domain
UIM (PF02809): Ubiquitin interaction motif
Erbb2
oncogene300.39785.540Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Rifin_STEVOR (PF02009): Rifin/stevor family
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Erbb3
oncogene250.42460.392Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
SKG6 (PF08693): Transmembrane alpha-helix domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Erbb4
interactor, oncogene, tumor suppressor150.6158.092Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
DUF3951 (PF13131): Protein of unknown function (DUF3951)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Evl
oncogene30.6670.167WH1 (PF00568): WH1 domain
Pex14_N (PF04695): Peroxisomal membrane anchor protein (Pex14p) conserved region
VASP_tetra (PF08776): VASP tetramerisation domain
Ewsr1
oncogene210.28474.525Keratin_2_head (PF16208): Keratin type II head
SVS_QK (PF10578): Seminal vesicle protein repeat
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Fos
oncogene60.5001.821bZIP_1 (PF00170): bZIP transcription factor
Fus
oncogene, tumor suppressor240.31595.095Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Gpx1
oncogene21.0000GSHPx (PF00255): Glutathione peroxidase
Grap2
interactor60.7330.949SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Grb10
oncogene60.6670.987RA (PF00788): Ras association (RalGDS/AF-6) domain
PH (PF00169): PH domain
BPS (PF08947): BPS (Between PH and SH2)
SH2 (PF00017): SH2 domain
Grb2
oncogene540.284427.432SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Hck
oncogene150.46719.015SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Hnrnpm
interactor130.47417.773HnRNP_M (PF11532): Heterogeneous nuclear ribonucleoprotein M
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Collagen_mid (PF15984): Bacterial collagen, middle region
Hsp90aa1
oncogene350.298183.028HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Hspa4
heat shock210.41945.239HSP70 (PF00012): Hsp70 protein
Herpes_ICP4_N (PF03584): Herpesvirus ICP4-like protein N-terminal region
Hspa8
heat shock, oncogene340.346171.490HSP70 (PF00012): Hsp70 protein
Hspd1
oncogene, tumor suppressor110.6733.806Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family
Huwe1
oncogene300.318132.499DUF908 (PF06012): Domain of Unknown Function (DUF908)
DUF913 (PF06025): Domain of Unknown Function (DUF913)
PBP_sp32 (PF07222): Proacrosin binding protein sp32
UBA (PF00627): UBA/TS-N domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhE (PF04216): Protein involved in formate dehydrogenase formation
WWE (PF02825): WWE domain
BSP_II (PF05432): Bone sialoprotein II (BSP-II)
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
Nop14 (PF04147): Nop14-like family
DUF4414 (PF14377): Domain of unknown function (DUF4414)
Mucin (PF01456): Mucin-like glycoprotein
BUD22 (PF09073): BUD22
HABP4_PAI-RBP1 (PF04774): Hyaluronan / mRNA binding family
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ilf3
oncogene100.5119.693DZF (PF07528): DZF domain
dsrm (PF00035): Double-stranded RNA binding motif
Herpes_PAP (PF03325): Herpesvirus polymerase accessory protein
Inppl1
oncogene190.53826.994SH2 (PF00017): SH2 domain
Exo_endo_phos (PF03372): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Jak1
oncogene150.46220.314FERM_M (PF00373): FERM central domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Jun
oncogene160.35234.455Jun (PF03957): Jun-like transcription factor
bZIP_1 (PF00170): bZIP transcription factor
LOC103737054
interactor190.27549.197OrfB_Zn_ribbon (PF07282): Putative transposase DNA-binding domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
IBR (PF01485): IBR domain, a half RING-finger domain
LOC103738088
interactor170.61714.836SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
LOC103748852
interactor710.2081018.984Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Lars
interactor60.6003.417tRNA-synt_1 (PF00133): tRNA synthetases class I (I, L, M and V)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
Lats2
oncogene, tumor suppressor90.3578.025UBA (PF00627): UBA/TS-N domain
Cas_Cas6 (PF01881): CRISPR associated protein Cas6
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Lrrc59
interactor60.6672.033LRR_8 (PF13855): Leucine rich repeat
GAGA_bind (PF06217): GAGA binding protein-like family
DUF4366 (PF14283): Domain of unknown function (DUF4366)
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
Lrrk1
interactor90.5716.332Ank_2 (PF12796): Ankyrin repeats (3 copies)
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
TniB (PF05621): Bacterial TniB protein
Roc (PF08477): Ras of Complex, Roc, domain of DAPkinase
COR (PF16095): C-terminal of Roc, COR, domain
Pkinase (PF00069): Protein kinase domain
Mapt
interactor120.50012.720Tubulin-binding (PF00418): Tau and MAP protein, tubulin-binding repeat
Mdm2
oncogene350.223219.453SWIB (PF02201): SWIB/MDM2 domain
Presenilin (PF01080): Presenilin
DUF4194 (PF13835): Domain of unknown function (DUF4194)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-FPG_IleRS (PF06827): Zinc finger found in FPG and IleRS
Mdm4
oncogene170.50821.044SWIB (PF02201): SWIB/MDM2 domain
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
zf-FLZ (PF04570): zinc-finger of the FCS-type, C2-C2
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Msh5
interactor21.0000MutS_III (PF05192): MutS domain III
MutS_V (PF00488): MutS domain V
Mtor
oncogene150.36329.787IFRD (PF05004): Interferon-related developmental regulator (IFRD)
HEAT_2 (PF13646): HEAT repeats
V-ATPase_H_N (PF03224): V-ATPase subunit H
EPSP_synthase (PF00275): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
CLASP_N (PF12348): CLASP N terminal
HEAT_EZ (PF13513): HEAT-like repeat
HEAT (PF02985): HEAT repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Tti2 (PF10521): Tti2 family
TPR_19 (PF14559): Tetratricopeptide repeat
FAT (PF02259): FAT domain
FRB_dom (PF08771): FKBP12-rapamycin binding domain
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase
FATC (PF02260): FATC domain
Naa25
interactor31.0000Alkyl_sulf_dimr (PF14863): Alkyl sulfatase dimerisation
BTAD (PF03704): Bacterial transcriptional activator domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
NatB_MDM20 (PF09797): N-acetyltransferase B complex (NatB) non catalytic subunit
Nars
interactor50.7001.452tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
tRNA-synt_2 (PF00152): tRNA synthetases class II (D, K and N)
Nck1
oncogene170.45627.790SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Ncoa3
oncogene110.25523.594HLH (PF00010): Helix-loop-helix DNA-binding domain
PAS (PF00989): PAS fold
PAS_11 (PF14598): PAS domain
DUF2953 (PF11167): Protein of unknown function (DUF2953)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
SRC-1 (PF08832): Steroid receptor coactivator
DUF4927 (PF16279): Domain of unknown function (DUF4927)
Nuc_rec_co-act (PF08815): Nuclear receptor coactivator
DUF1518 (PF07469): Domain of unknown function (DUF1518)
Nedd4l
oncogene, tumor suppressor140.56410.008C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Nedd9
interactor80.5713.733SH3_9 (PF14604): Variant SH3 domain
DNA_pol3_tau_4 (PF12168): DNA polymerase III subunits tau domain IV DnaB-binding
Serine_rich (PF08824): Serine rich protein interaction domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)
Nfkbia
oncogene100.33316.779Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ntrk1
oncogene750.1571461.014LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Pag1
interactor70.8670.367PAG (PF15347): Phosphoprotein associated with glycosphingolipid-enriched
Pak2
interactor120.6007.829PBD (PF00786): P21-Rho-binding domain
Pkinase (PF00069): Protein kinase domain
Pak4
interactor160.44834.278PBD (PF00786): P21-Rho-binding domain
Pkinase (PF00069): Protein kinase domain
Parp1
tumor suppressor150.51613.500zf-PARP (PF00645): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
PADR1 (PF08063): PADR1 (NUC008) domain
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
WGR (PF05406): WGR domain
PARP_reg (PF02877): Poly(ADP-ribose) polymerase, regulatory domain
PARP (PF00644): Poly(ADP-ribose) polymerase catalytic domain
Pcna
oncogene170.46724.618PCNA_N (PF00705): Proliferating cell nuclear antigen, N-terminal domain
PCNA_C (PF02747): Proliferating cell nuclear antigen, C-terminal domain
Pfdn4
interactor30.6671.000Prefoldin_2 (PF01920): Prefoldin subunit
Pik3r1
oncogene350.358152.923SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Pik3r2
oncogene190.64914.486SH3_9 (PF14604): Variant SH3 domain
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Plcg1
oncogene210.46252.835PH_12 (PF16457): Pleckstrin homology domain
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
PH (PF00169): PH domain
SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Ppm1b
interactor80.4298.086PP2C (PF00481): Protein phosphatase 2C
PP2C_C (PF07830): Protein serine/threonine phosphatase 2C, C-terminal domain
Prdx1
oncogene90.6434.327AhpC-TSA (PF00578): AhpC/TSA family
1-cysPrx_C (PF10417): C-terminal domain of 1-Cys peroxiredoxin
Prkcz
interactor140.43619.405PB1 (PF00564): PB1 domain
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Psma4
interactor80.5367.267Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Psma7
interactor120.6007.509Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Psmd4
interactor120.6219.105VWA_2 (PF13519): von Willebrand factor type A domain
VWA (PF00092): von Willebrand factor type A domain
UIM (PF02809): Ubiquitin interaction motif
Ptges3
interactor70.7331.046CS (PF04969): CS domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Ptpn6
oncogene, tumor suppressor130.6976.390SH2 (PF00017): SH2 domain
PolyA_pol_arg_C (PF12626): Polymerase A arginine-rich C-terminus
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
Rad51
interactor70.8000.718HHH_5 (PF14520): Helix-hairpin-helix domain
Rad51 (PF08423): Rad51
Ran
oncogene80.42910.521Ras (PF00071): Ras family
Rapgef1
oncogene100.7333.525RasGEF_N (PF00618): RasGEF N-terminal motif
RasGEF (PF00617): RasGEF domain
Rasa1
oncogene200.38956.557SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PH (PF00169): PH domain
C2 (PF00168): C2 domain
RasGAP (PF00616): GTPase-activator protein for Ras-like GTPase
Rb1
oncogene, tumor suppressor180.34056.125TFIIB (PF00382): Transcription factor TFIIB repeat
DUF3452 (PF11934): Domain of unknown function (DUF3452)
RB_A (PF01858): Retinoblastoma-associated protein A domain
DUF4592 (PF15262): Domain of unknown function (DUF4592)
RB_B (PF01857): Retinoblastoma-associated protein B domain
Rb_C (PF08934): Rb C-terminal domain
Reps1
interactor60.7001.054EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
DUF3123 (PF11321): Protein of unknown function (DUF3123)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Rfx1
interactor40.6670.900LCE6A (PF15858): Late cornified envelope protein 6A family
RFX1_trans_act (PF04589): RFX1 transcription activation region
RFX_DNA_binding (PF02257): RFX DNA-binding domain
Pex14_N (PF04695): Peroxisomal membrane anchor protein (Pex14p) conserved region
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Rin1
interactor90.5834.689SH2 (PF00017): SH2 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VPS9 (PF02204): Vacuolar sorting protein 9 (VPS9) domain
RA (PF00788): Ras association (RalGDS/AF-6) domain
Rplp1
interactor40.6670.286Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Rps6kb1
interactor100.5007.274Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Rybp
interactor60.8000.954zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
DUF4808 (PF16066): Domain of unknown function (DUF4808)
CPSF100_C (PF13299): Cleavage and polyadenylation factor 2 C-terminal
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
Sfn
tumor suppressor260.34098.28714-3-3 (PF00244): 14-3-3 protein
Sh3bp1
interactor51.0000BAR (PF03114): BAR domain
RhoGAP (PF00620): RhoGAP domain
Sh3kbp1
interactor180.52228.474SH3_9 (PF14604): Variant SH3 domain
DUF4078 (PF13300): Domain of unknown function (DUF4078)
Tmemb_cc2 (PF10267): Predicted transmembrane and coiled-coil 2 protein
Shb
interactor90.7222.156Herpes_capsid (PF06112): Gammaherpesvirus capsid protein
Period_C (PF12114): Period protein 2/3C-terminal region
SH2 (PF00017): SH2 domain
Shc1
oncogene370.352175.766PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Shd
interactor100SH2 (PF00017): SH2 domain
She
interactor100SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SH2 (PF00017): SH2 domain
Slc9a2
oncogene40.6671.667Na_H_Exchanger (PF00999): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
Socs1
oncogene, tumor suppressor140.51618.411SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Socs3
tumor suppressor60.6002.900SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Sorbs1
interactor80.5715.287Sorb (PF02208): Sorbin homologous domain
SCAB-ABD (PF16711): Actin-binding domain of plant-specific actin-binding protein
SH3_9 (PF14604): Variant SH3 domain
SH3_2 (PF07653): Variant SH3 domain
SH3_1 (PF00018): SH3 domain
Sorbs2
interactor, oncogene110.5568.148Sorb (PF02208): Sorbin homologous domain
Dmrt1 (PF12374): Double-sex mab3 related transcription factor 1
SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
Sos1
oncogene180.52927.417Histone (PF00125): Core histone H2A/H2B/H3/H4
RhoGEF (PF00621): RhoGEF domain
DUF445 (PF04286): Protein of unknown function (DUF445)
PH (PF00169): PH domain
RasGEF_N (PF00618): RasGEF N-terminal motif
RasGEF (PF00617): RasGEF domain
Spag9
interactor31.0000Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
DUF501 (PF04417): Protein of unknown function (DUF501)
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF972 (PF06156): Protein of unknown function (DUF972)
ERM (PF00769): Ezrin/radixin/moesin family
TACC (PF05010): Transforming acidic coiled-coil-containing protein (TACC)
IncA (PF04156): IncA protein
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
FYDLN_acid (PF09538): Protein of unknown function (FYDLN_acid)
Spta1
interactor80.5246.719Spectrin (PF00435): Spectrin repeat
SH3_1 (PF00018): SH3 domain
EF-hand_7 (PF13499): EF-hand domain pair
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand
Sptan1
oncogene100.5788.055Tetrabrachion (PF11401): Tetrabrachion
Spectrin (PF00435): Spectrin repeat
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand
SH3_1 (PF00018): SH3 domain
DUF16 (PF01519): Protein of unknown function DUF16
E2F_CC-MB (PF16421): E2F transcription factor CC-MB domain
EF-hand_7 (PF13499): EF-hand domain pair
Src
oncogene370.252296.329SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Srpk2
oncogene100.44411.914YrzO (PF14142): YrzO-like protein
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Pkinase (PF00069): Protein kinase domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
CNDH2_C (PF16858): Condensin II complex subunit CAP-H2 or CNDH2, C-term
S-antigen (PF05756): S-antigen protein
St5
oncogene, tumor suppressor21.0000SEEEED (PF14797): Serine-rich region of AP3B1, clathrin-adaptor complex
uDENN (PF03456): uDENN domain
DENN (PF02141): DENN (AEX-3) domain
dDENN (PF03455): dDENN domain
Ston2
interactor31.0000Stonin2_N (PF12016): Stonin 2
Adap_comp_sub (PF00928): Adaptor complexes medium subunit family
Stub1
tumor suppressor200.42145.337ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
U-box (PF04564): U-box domain
Topbp1
interactor70.7331.283PTCB-BRCT (PF12738): twin BRCT domain
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
DUF521 (PF04412): Protein of unknown function (DUF521)
Tp53
tumor suppressor460.218443.927P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif
Tp73
oncogene, tumor suppressor100.5564.313P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif
SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Tub
interactor21.0000Tub_N (PF16322): Tubby N-terminal
Tub (PF01167): Tub family
Ubash3b
interactor190.50329.038UBA (PF00627): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604): Variant SH3 domain
His_Phos_1 (PF00300): Histidine phosphatase superfamily (branch 1)
Ubc
interactor360.308188.478ubiquitin (PF00240): Ubiquitin family
Usp7
oncogene130.53012.010MATH (PF00917): MATH domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
USP7_C2 (PF14533): Ubiquitin-specific protease C-terminal
USP7_ICP0_bdg (PF12436): ICP0-binding domain of Ubiquitin-specific protease 7
Vav1
oncogene170.50030.778CH (PF00307): Calponin homology (CH) domain
RhoGEF (PF00621): RhoGEF domain
IL5 (PF02025): Interleukin 5
PH (PF00169): PH domain
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Wasf1
interactor50.6001.889Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif
Wrnip1
interactor60.7000.667Sgf11 (PF08209): Sgf11 (transcriptional regulation protein)
DUF1180 (PF06679): Protein of unknown function (DUF1180)
DLEU7 (PF15760): Leukemia-associated protein 7
RuvB_N (PF05496): Holliday junction DNA helicase ruvB N-terminus
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
AAA_assoc_2 (PF16193): AAA C-terminal domain
MgsA_C (PF12002): MgsA AAA+ ATPase C terminal
Xpo1
interactor370.218319.639IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Xrcc6
oncogene150.34131.318Ku_N (PF03731): Ku70/Ku80 N-terminal alpha/beta domain
Ku (PF02735): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
SAP (PF02037): SAP domain
Ythdc1
interactor31.0000MMU163 (PF17119): Mitochondrial protein up-regulated during meiosis
Trypan_PARP (PF05887): Procyclic acidic repetitive protein (PARP)
Merozoite_SPAM (PF07133): Merozoite surface protein (SPAM)
Paf1 (PF03985): Paf1
YTH (PF04146): YT521-B-like domain
Ywhab
interactor210.51937.310Virulence_fact (PF13769): Virulence factor
14-3-3 (PF00244): 14-3-3 protein
Ywhae
oncogene240.36678.17914-3-3 (PF00244): 14-3-3 protein
Ywhag
interactor230.47242.71414-3-3 (PF00244): 14-3-3 protein
Ywhah
interactor190.51625.41514-3-3 (PF00244): 14-3-3 protein
Ywhaq
interactor260.38594.62514-3-3 (PF00244): 14-3-3 protein
Ywhaz
interactor300.40690.54014-3-3 (PF00244): 14-3-3 protein
Zdhhc16
interactor100NS3_envE (PF02723): Non-structural protein NS3/Small envelope protein E
zf-DHHC (PF01529): DHHC palmitoyltransferase
DUF1049 (PF06305): Protein of unknown function (DUF1049)

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