Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abi3 (from a repository: Fri Apr 13 10:13:32 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)63 (19.38 %)
The number (and %) of affected PPIs26 (41.27 %)
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.2054
The network average Clustering coefficient0.620
The number (and %) of a zero Clustering coefficients3 (11.54 %)
The number (and %) of a zero Betweenness Centrality11 (42.31 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abi3
user protein260.090499.000Abi_HHR (PF07815): Abl-interactor HHR
SH3_9 (PF14604): Variant SH3 domain
Abi3bp
interactor21.0000fn3 (PF00041): Fibronectin type III domain
Pur_ac_phosph_N (PF16656): Purple acid Phosphatase, N-terminal domain
Cep44
interactor21.0000CEP44 (PF15007): Centrosomal spindle body, CEP44
Dtnb
interactor31.0000EF-hand_2 (PF09068): EF hand
EF-hand_3 (PF09069): EF-hand
ZZ (PF00569): Zinc finger, ZZ type
Ax_dynein_light (PF10211): Axonemal dynein light chain
CRISPR_Cse2 (PF09485): CRISPR-associated protein Cse2 (CRISPR_cse2)
SOGA (PF11365): Protein SOGA
Dtnbp1
interactor30.6671.000Sec34 (PF04136): Sec34-like family
OmpH (PF03938): Outer membrane protein (OmpH-like)
Dysbindin (PF04440): Dysbindin (Dystrobrevin binding protein 1)
Enah
oncogene31.0000WH1 (PF00568): WH1 domain
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Herpes_UL25 (PF01499): Herpesvirus UL25 family
SMN (PF06003): Survival motor neuron protein (SMN)
DDHD (PF02862): DDHD domain
DUF4407 (PF14362): Domain of unknown function (DUF4407)
VASP_tetra (PF08776): VASP tetramerisation domain
Evl
oncogene40.6672.000WH1 (PF00568): WH1 domain
Pex14_N (PF04695): Peroxisomal membrane anchor protein (Pex14p) conserved region
VASP_tetra (PF08776): VASP tetramerisation domain
Fbf1
interactor30.6671.000KfrA_N (PF11740): Plasmid replication region DNA-binding N-term
XhlA (PF10779): Haemolysin XhlA
DUF106 (PF01956): Integral membrane protein DUF106
Thioredoxin_4 (PF13462): Thioredoxin
DUF3450 (PF11932): Protein of unknown function (DUF3450)
IFT20 (PF14931): Intraflagellar transport complex B, subunit 20
Spc24 (PF08286): Spc24 subunit of Ndc80
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Grb2
oncogene70.4009.000SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Homer1
interactor21.0000WH1 (PF00568): WH1 domain
DUF3508 (PF12018): Domain of unknown function (DUF3508)
FTCD_C (PF04961): Formiminotransferase-cyclodeaminase
GAS (PF13851): Growth-arrest specific micro-tubule binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
Homer3
interactor60.4006.000WH1 (PF00568): WH1 domain
Sec66 (PF09802): Preprotein translocase subunit Sec66
Spc7 (PF08317): Spc7 kinetochore protein
Cep57_CLD_2 (PF14197): Centrosome localisation domain of PPC89
MerR-DNA-bind (PF09278): MerR, DNA binding
Kank2
interactor200KN_motif (PF12075): KN motif
G_path_suppress (PF15991): G-protein pathway suppressor
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Kiaa0408
interactor30.6671.000DUF4482 (PF14818): Domain of unknown function (DUF4482)
Klc4
interactor30.6671.000LUD_dom (PF02589): LUD domain
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_10 (PF13374): Tetratricopeptide repeat
Krt13
interactor30.6671.000Keratin_2_head (PF16208): Keratin type II head
Filament (PF00038): Intermediate filament protein
FliD_N (PF02465): Flagellar hook-associated protein 2 N-terminus
Krt15
interactor50.4006.000Keratin_2_head (PF16208): Keratin type II head
Filament (PF00038): Intermediate filament protein
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
Nck2
interactor70.4009.000SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nup58
interactor100Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
Pak1
interactor, oncogene41.0000PBD (PF00786): P21-Rho-binding domain
Pkinase (PF00069): Protein kinase domain
Pak2
interactor41.0000PBD (PF00786): P21-Rho-binding domain
Pkinase (PF00069): Protein kinase domain
Psma1
interactor40.6671.000Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Runx1t1
oncogene31.0000DUF1179 (PF06678): Protein of unknown function (DUF1179)
TAFH (PF07531): NHR1 homology to TAF
NHR2 (PF08788): NHR2 domain like
DUF4434 (PF14488): Domain of unknown function (DUF4434)
DUF3731 (PF12531): DNA-K related protein
zf-MYND (PF01753): MYND finger
Tmem147
interactor100DUF2053 (PF09767): Predicted membrane protein (DUF2053)
Vasp
interactor60.6004.000WH1 (PF00568): WH1 domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
ASD2 (PF08687): Apx/Shroom domain ASD2
VASP_tetra (PF08776): VASP tetramerisation domain
Was
oncogene40.6672.000WH1 (PF00568): WH1 domain
MSA-2c (PF12238): Merozoite surface antigen 2c
PBD (PF00786): P21-Rho-binding domain
TonB_2 (PF13103): TonB C terminal
WH2 (PF02205): WH2 motif
Wasf2
oncogene40.5003.000WASH_WAHD (PF11945): WAHD domain of WASH complex
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif

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