Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abi2 (from a repository: Fri Apr 20 21:08:46 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)93
The number (and %) of the onco-proteins15 (16.13 %)
The number (and %) of the tumor suppressors9 (9.68 %)
Total number of binary PPIs (saturation %)384 (8.98 %)
The number (and %) of affected PPIs93 (24.22 %)
PPI diameter2
PPI radius1
The average degree of PPI7.656
Assortativity coefficient-0.3605
The network average Clustering coefficient0.564
The number (and %) of a zero Clustering coefficients7 (7.53 %)
The number (and %) of a zero Betweenness Centrality23 (24.73 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abi2
user protein, tumor suppressor930.0636434.652ATP-synt_ab_Xtn (PF16886): ATPsynthase alpha/beta subunit N-term extension
Abi_HHR (PF07815): Abl-interactor HHR
NUDE_C (PF04880): NUDE protein, C-terminal conserved region
Axin_b-cat_bind (PF08833): Axin beta-catenin binding domain
TMEM171 (PF15471): Transmembrane protein family 171
SH3_9 (PF14604): Variant SH3 domain
Abi1
oncogene280.265192.907Acid_PPase (PF12689): Acid Phosphatase
Abi_HHR (PF07815): Abl-interactor HHR
Cytochrom_B558a (PF05038): Cytochrome Cytochrome b558 alpha-subunit
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VIR_N (PF15912): Virilizer, N-terminal
SH3_1 (PF00018): SH3 domain
Abl1
interactor, oncogene60.7001.333SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF4124 (PF13511): Domain of unknown function (DUF4124)
F_actin_bind (PF08919): F-actin binding
Abl2
oncogene50.6670.667SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
RGS12_us1 (PF16613): Unstructured region of RGS12
F_actin_bind (PF08919): F-actin binding
Adam19
interactor100Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain
Adeno_E3_CR2 (PF02439): Adenovirus E3 region protein CR2
Aes
interactor140.28248.367TLE_N (PF03920): Groucho/TLE N-terminal Q-rich domain
Amz1
interactor90.6674.258Peptidase_M54 (PF07998): Peptidase family M54
Appl2
interactor30.6671.000BAR_3 (PF16746): BAR domain of APPL family
PH (PF00169): PH domain
PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
Arhgap32
oncogene50.4002.852PX (PF00787): PX domain
SH3_9 (PF14604): Variant SH3 domain
RPEL (PF02755): RPEL repeat
RhoGAP (PF00620): RhoGAP domain
Armc7
interactor30.6670.400Arm (PF00514): Armadillo/beta-catenin-like repeat
Bloc1s6
interactor80.6196.400Snapin_Pallidin (PF14712): Snapin/Pallidin
BRE1 (PF08647): BRE1 E3 ubiquitin ligase
Brk1
interactor90.5835.068DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Cap1
interactor31.0000CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
CAP_C (PF08603): Adenylate cyclase associated (CAP) C terminal
Caskin2
interactor21.0000Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SH3_2 (PF07653): Variant SH3 domain
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Caskin-tail (PF16632): C-terminal region of Caskin
Cblc
oncogene80.5715.258Cbl_N (PF02262): CBL proto-oncogene N-terminal domain 1
zf-RING_UBOX (PF13445): RING-type zinc-finger
Cbl_N2 (PF02761): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
Ccdc102b
interactor40.6670.667AAA_13 (PF13166): AAA domain
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
APG6 (PF04111): Autophagy protein Apg6
YlqD (PF11068): YlqD protein
Ccdc22
interactor40.6672.000DUF812 (PF05667): Protein of unknown function (DUF812)
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Ccdc36
interactor21.0000DUF4700 (PF15771): Domain of unknown function (DUF4700)
Cchcr1
interactor90.42911.500HCR (PF07111): Alpha helical coiled-coil rod protein (HCR)
Cdk6
oncogene, tumor suppressor31.0000Pkinase (PF00069): Protein kinase domain
Cep44
interactor21.0000CEP44 (PF15007): Centrosomal spindle body, CEP44
Crx
interactor21.0000Homeobox (PF00046): Homeobox domain
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
TF_Otx (PF03529): Otx1 transcription factor
Cyfip1
interactor160.47523.560DUF1394 (PF07159): Protein of unknown function (DUF1394)
zf-CW (PF07496): CW-type Zinc Finger
FragX_IP (PF05994): Cytoplasmic Fragile-X interacting family
Cyfip2
interactor200.37955.879DUF1394 (PF07159): Protein of unknown function (DUF1394)
zf-CW (PF07496): CW-type Zinc Finger
FragX_IP (PF05994): Cytoplasmic Fragile-X interacting family
Dtnb
interactor40.6670.333EF-hand_2 (PF09068): EF hand
EF-hand_3 (PF09069): EF-hand
ZZ (PF00569): Zinc finger, ZZ type
Ax_dynein_light (PF10211): Axonemal dynein light chain
CRISPR_Cse2 (PF09485): CRISPR-associated protein Cse2 (CRISPR_cse2)
SOGA (PF11365): Protein SOGA
Efs
interactor100SH3_9 (PF14604): Variant SH3 domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)
Egln3
hypoxia, tumor suppressor2002OG-FeII_Oxy_3 (PF13640): 2OG-Fe(II) oxygenase superfamily
Enah
oncogene40.6670.567WH1 (PF00568): WH1 domain
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Herpes_UL25 (PF01499): Herpesvirus UL25 family
SMN (PF06003): Survival motor neuron protein (SMN)
DDHD (PF02862): DDHD domain
DUF4407 (PF14362): Domain of unknown function (DUF4407)
VASP_tetra (PF08776): VASP tetramerisation domain
Exoc7
interactor50.6002.619COG5 (PF10392): Golgi transport complex subunit 5
Sec34 (PF04136): Sec34-like family
Exo70 (PF03081): Exo70 exocyst complex subunit
Gcc1
interactor30.6671.000DUF972 (PF06156): Protein of unknown function (DUF972)
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
LPP (PF04728): Lipoprotein leucine-zipper
IFP_35_N (PF07334): Interferon-induced 35 kDa protein (IFP 35) N-terminus
FlaC_arch (PF05377): Flagella accessory protein C (FlaC)
GrpE (PF01025): GrpE
TMPIT (PF07851): TMPIT-like protein
Spc24 (PF08286): Spc24 subunit of Ndc80
ZapB (PF06005): Cell division protein ZapB
GRIP (PF01465): GRIP domain
Grn
oncogene40.5001.452Granulin (PF00396): Granulin
Lustrin_cystein (PF14625): Lustrin, cysteine-rich repeated domain
Hgs
interactor120.31836.852VHS (PF00790): VHS domain
FYVE (PF01363): FYVE zinc finger
UIM (PF02809): Ubiquitin interaction motif
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
DUF3306 (PF11748): Protein of unknown function (DUF3306)
Hrs_helical (PF12210): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917): Piezo
Hnrnpk
oncogene100.44412.971ROKNT (PF08067): ROKNT (NUC014) domain
KH_1 (PF00013): KH domain
Homer3
interactor70.7332.333WH1 (PF00568): WH1 domain
Sec66 (PF09802): Preprotein translocase subunit Sec66
Spc7 (PF08317): Spc7 kinetochore protein
Cep57_CLD_2 (PF14197): Centrosome localisation domain of PPC89
MerR-DNA-bind (PF09278): MerR, DNA binding
Ift20
interactor70.5247.667IFT20 (PF14931): Intraflagellar transport complex B, subunit 20
Ikbip
interactor70.3339.833PspB (PF06667): Phage shock protein B
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
COG2 (PF06148): COG (conserved oligomeric Golgi) complex component, COG2
Khdrbs1
interactor60.7001.119Totivirus_coat (PF05518): Totivirus coat protein
Qua1 (PF16274): Qua1 domain
KH_1 (PF00013): KH domain
Sam68-YY (PF16568): Tyrosine-rich domain of Sam68
Kiaa0355
interactor21.0000DUF4745 (PF15923): Domain of unknown function (DUF4745)
Pex14_N (PF04695): Peroxisomal membrane anchor protein (Pex14p) conserved region
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Kiaa1217
interactor40.5003.000CorA (PF01544): CorA-like Mg2+ transporter protein
KIP1 (PF07765): KIP1-like protein
CHDCT2 (PF08074): CHDCT2 (NUC038) domain
OmpH (PF03938): Outer membrane protein (OmpH-like)
MRI (PF15325): Modulator of retrovirus infection
DUF2525 (PF10733): Protein of unknown function (DUF2525)
DUF1180 (PF06679): Protein of unknown function (DUF1180)
Kiaa1522
interactor31.0000Hamartin (PF04388): Hamartin protein
NHS (PF15273): NHS-like
Kifc3
oncogene100.38917.333HALZ (PF02183): Homeobox associated leucine zipper
Spc7 (PF08317): Spc7 kinetochore protein
KxDL (PF10241): Uncharacterized conserved protein
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Kinesin (PF00225): Kinesin motor domain
Krt13
interactor50.6002.900Keratin_2_head (PF16208): Keratin type II head
Filament (PF00038): Intermediate filament protein
FliD_N (PF02465): Flagellar hook-associated protein 2 N-terminus
Krt15
interactor120.30339.800Keratin_2_head (PF16208): Keratin type II head
Filament (PF00038): Intermediate filament protein
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
Krt18
interactor130.28837.133Filament (PF00038): Intermediate filament protein
Spc7 (PF08317): Spc7 kinetochore protein
Krt19
oncogene, tumor suppressor60.7001.400POX (PF07526): Associated with HOX
Filament (PF00038): Intermediate filament protein
Krt20
interactor21.0000Filament (PF00038): Intermediate filament protein
Spc7 (PF08317): Spc7 kinetochore protein
Tropomyosin_1 (PF12718): Tropomyosin like
LOC103732255
interactor40.8330.286Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain
LOC103739855
interactor21.0000tRNA-synt_1 (PF00133): tRNA synthetases class I (I, L, M and V)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
LOC103745619
interactor70.6674.400TPR_1 (PF00515): Tetratricopeptide repeat
TPR_11 (PF13414): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Ran_BP1 (PF00638): RanBP1 domain
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Dmrt1 (PF12374): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371): Tetratricopeptide repeat
IR1-M (PF12185): Nup358/RanBP2 E3 ligase domain
Pro_isomerase (PF00160): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Lhx4
tumor suppressor50.9000.125LIM (PF00412): LIM domain
Homeobox (PF00046): Homeobox domain
Lmo2
oncogene30.6671.000CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412): LIM domain
Mov10
interactor50.6002.233AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
Nck2
interactor250.225175.765SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nckap1
interactor190.49141.990Nckap1 (PF09735): Membrane-associated apoptosis protein
Nckap1l
interactor40.8330.125Nckap1 (PF09735): Membrane-associated apoptosis protein
Nhsl1
interactor50.6003.222NHS (PF15273): NHS-like
Nhsl2
interactor80.9290.258NHS (PF15273): NHS-like
Ntrk1
oncogene290.132283.135LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nup62
interactor130.30337.467Nucleoporin_FG (PF13634): Nucleoporin FG repeat region
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
Nsp1_C (PF05064): Nsp1-like C-terminal region
PUMA (PF15826): Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
Laminin_II (PF06009): Laminin Domain II
Nxf1
interactor120.30929.467Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Obsl1
interactor130.27338.900I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Pcm1
oncogene80.28615.786PCRF (PF03462): PCRF domain
Spt5_N (PF11942): Spt5 transcription elongation factor, acidic N-terminal
sCache_like (PF16736): Single Cache-like
GOLD_2 (PF13897): Golgi-dynamics membrane-trafficking
IncA (PF04156): IncA protein
RP-C_C (PF11800): Replication protein C C-terminal region
YlqD (PF11068): YlqD protein
IBN_N (PF03810): Importin-beta N-terminal domain
NPV_P10 (PF05531): Nucleopolyhedrovirus P10 protein
FliD_N (PF02465): Flagellar hook-associated protein 2 N-terminus
PCM1_C (PF15717): Pericentriolar material 1 C terminus
Pcmt1
interactor50.6002.119PCMT (PF01135): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
Pin1
tumor suppressor60.3336.300WW (PF00397): WW domain
Rotamase (PF00639): PPIC-type PPIASE domain
Ppif
interactor100Pro_isomerase (PF00160): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Pram1
interactor100hSH3 (PF14603): Helically-extended SH3 domain
Prkaa1
tumor suppressor60.5333.400Pkinase (PF00069): Protein kinase domain
AdenylateSensor (PF16579): Adenylate sensor of SNF1-like protein kinase
Prkaa2
tumor suppressor60.6672.800Pkinase (PF00069): Protein kinase domain
AdenylateSensor (PF16579): Adenylate sensor of SNF1-like protein kinase
Prr16
interactor100Baculo_p24 (PF05073): Baculovirus P24 capsid protein
DUF4589 (PF15252): Domain of unknown function (DUF4589)
Ptpru
oncogene21.0000MAM (PF00629): MAM domain, meprin/A5/mu
fn3 (PF00041): Fibronectin type III domain
PsbX (PF06596): Photosystem II reaction centre X protein (PsbX)
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
Sass6
interactor21.0000SAS-6_N (PF16531): Centriolar protein SAS N-terminal
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
CALCOCO1 (PF07888): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF2951 (PF11166): Protein of unknown function (DUF2951)
Sdcbp
interactor70.28614.067PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Shmt2
interactor40.6670.686SHMT (PF00464): Serine hydroxymethyltransferase
Stam2
interactor21.0000VHS (PF00790): VHS domain
UIM (PF02809): Ubiquitin interaction motif
SH3_1 (PF00018): SH3 domain
GAT (PF03127): GAT domain
Tcf4
tumor suppressor120.45528.033CDC45 (PF02724): CDC45-like protein
HLH (PF00010): Helix-loop-helix DNA-binding domain
MAGE_N (PF12440): Melanoma associated antigen family N terminal
Tfip11
interactor70.33311.519TIP_N (PF12457): Tuftelin interacting protein N terminal
G-patch (PF01585): G-patch domain
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
GCFC (PF07842): GC-rich sequence DNA-binding factor-like protein
Timm50
interactor100.6449.369NIF (PF03031): NLI interacting factor-like phosphatase
Tnip1
interactor60.4003.667Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
Pinin_SDK_memA (PF04696): pinin/SDK/memA/ protein conserved region
DUF4337 (PF14235): Domain of unknown function (DUF4337)
Filament (PF00038): Intermediate filament protein
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
Mnd1 (PF03962): Mnd1 family
Tpm1
interactor31.0000Tropomyosin_1 (PF12718): Tropomyosin like
Tropomyosin (PF00261): Tropomyosin
Traf3ip1
interactor21.0000MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Trim32
tumor suppressor31.0000zf-RING_UBOX (PF13445): RING-type zinc-finger
Zn_Tnp_IS1595 (PF12760): Transposase zinc-ribbon domain
zf-B_box (PF00643): B-box zinc finger
NHL (PF01436): NHL repeat
Trip6
interactor50.4005.250zf-dskA_traR (PF01258): Prokaryotic dksA/traR C4-type zinc finger
LIM (PF00412): LIM domain
Ubr3
interactor100zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
CRAL_TRIO (PF00650): CRAL/TRIO domain
zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
Ubxn11
interactor80.6435.625IncA (PF04156): IncA protein
TRPM_tetra (PF16519): Tetramerisation domain of TRPM
SEP (PF08059): SEP domain
UBX (PF00789): UBX domain
Vasp
interactor80.38110.333WH1 (PF00568): WH1 domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
ASD2 (PF08687): Apx/Shroom domain ASD2
VASP_tetra (PF08776): VASP tetramerisation domain
Vcl
oncogene50.5002.400Vinculin (PF01044): Vinculin family
Wasf1
interactor180.41845.769Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif
Wasf2
oncogene170.45629.769WASH_WAHD (PF11945): WAHD domain of WASH complex
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif
Wasf3
interactor100.6445.538ChaB (PF06150): ChaB
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
RCDG1 (PF15725): Renal cancer differentiation gene 1 protein
WH2 (PF02205): WH2 motif
Washc3
interactor120.28836.378DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Wasl
interactor90.50010.644WH1 (PF00568): WH1 domain
NUP50 (PF08911): NUP50 (Nucleoporin 50 kDa)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
PBD (PF00786): P21-Rho-binding domain
WH2 (PF02205): WH2 motif
Wipf1
interactor40.6670.833CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
WH2 (PF02205): WH2 motif
GRP (PF07172): Glycine rich protein family
Znf511
interactor70.9050.258zf-C2H2_aberr (PF17017): Aberrant zinc-finger
zf-C2H2 (PF00096): Zinc finger, C2H2 type
CHORD (PF04968): CHORD

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