Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abi1 (from a repository: Fri Apr 13 14:53:06 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins11 (19.64 %)
The number (and %) of the tumor suppressors5 (8.93 %)
Total number of binary PPIs (saturation %)244 (15.84 %)
The number (and %) of affected PPIs55 (22.54 %)
PPI diameter2
PPI radius1
The average degree of PPI8.214
Assortativity coefficient-0.4072
The network average Clustering coefficient0.608
The number (and %) of a zero Clustering coefficients7 (12.50 %)
The number (and %) of a zero Betweenness Centrality17 (30.36 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abi1
user protein, oncogene550.1181910.907Acid_PPase (PF12689): Acid Phosphatase
Abi_HHR (PF07815): Abl-interactor HHR
Cytochrom_B558a (PF05038): Cytochrome Cytochrome b558 alpha-subunit
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VIR_N (PF15912): Virilizer, N-terminal
SH3_1 (PF00018): SH3 domain
Abi2
tumor suppressor290.265197.179ATP-synt_ab_Xtn (PF16886): ATPsynthase alpha/beta subunit N-term extension
Abi_HHR (PF07815): Abl-interactor HHR
NUDE_C (PF04880): NUDE protein, C-terminal conserved region
Axin_b-cat_bind (PF08833): Axin beta-catenin binding domain
TMEM171 (PF15471): Transmembrane protein family 171
SH3_9 (PF14604): Variant SH3 domain
Abl1
interactor, oncogene80.6195.567SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF4124 (PF13511): Domain of unknown function (DUF4124)
F_actin_bind (PF08919): F-actin binding
Amz1
interactor90.6674.410Peptidase_M54 (PF07998): Peptidase family M54
Apbb1
interactor90.4646.578RNA_pol_3_Rpc31 (PF11705): DNA-directed RNA polymerase III subunit Rpc31
WW (PF00397): WW domain
PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
Baiap2
interactor120.49116.940IMD (PF08397): IRSp53/MIM homology domain
SH3_9 (PF14604): Variant SH3 domain
Brk1
interactor80.6792.847DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Cacna1a
interactor100Fungus-induced (PF10917): Fungus-induced protein
Ion_trans (PF00520): Ion transport protein
PNK3P (PF08645): Polynucleotide kinase 3 phosphatase
GPHH (PF16905): Voltage-dependent L-type calcium channel, IQ-associated
Ca_chan_IQ (PF08763): Voltage gated calcium channel IQ domain
SelP_N (PF04592): Selenoprotein P, N terminal region
Cbl
oncogene, tumor suppressor80.7143.333Cbl_N (PF02262): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
UBA (PF00627): UBA/TS-N domain
Ccdc22
interactor40.8330.286DUF812 (PF05667): Protein of unknown function (DUF812)
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Cdc123
interactor100D123 (PF07065): D123
Cog6
interactor31.0000COG6 (PF06419): Conserved oligomeric complex COG6
Cttn
oncogene40.6671.000HS1_rep (PF02218): Repeat in HS1/Cortactin
FadA (PF09403): Adhesion protein FadA
SH3_9 (PF14604): Variant SH3 domain
Cyfip1
interactor220.33872.658DUF1394 (PF07159): Protein of unknown function (DUF1394)
zf-CW (PF07496): CW-type Zinc Finger
FragX_IP (PF05994): Cytoplasmic Fragile-X interacting family
Cyfip2
interactor240.30896.358DUF1394 (PF07159): Protein of unknown function (DUF1394)
zf-CW (PF07496): CW-type Zinc Finger
FragX_IP (PF05994): Cytoplasmic Fragile-X interacting family
Dtnbp1
interactor80.5367.000Sec34 (PF04136): Sec34-like family
OmpH (PF03938): Outer membrane protein (OmpH-like)
Dysbindin (PF04440): Dysbindin (Dystrobrevin binding protein 1)
Enah
oncogene50.6001.486WH1 (PF00568): WH1 domain
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Herpes_UL25 (PF01499): Herpesvirus UL25 family
SMN (PF06003): Survival motor neuron protein (SMN)
DDHD (PF02862): DDHD domain
DUF4407 (PF14362): Domain of unknown function (DUF4407)
VASP_tetra (PF08776): VASP tetramerisation domain
Eps8
oncogene50.6671.333PTB (PF08416): Phosphotyrosine-binding domain
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Med2 (PF11214): Mediator complex subunit 2
SH3_3 (PF08239): Bacterial SH3 domain
SH3_1 (PF00018): SH3 domain
DEC-1_N (PF04625): DEC-1 protein, N-terminal region
Eps8l1
interactor21.0000PTB (PF08416): Phosphotyrosine-binding domain
SH3_1 (PF00018): SH3 domain
Eps8l2
interactor21.0000PTB (PF08416): Phosphotyrosine-binding domain
SH3_1 (PF00018): SH3 domain
hSH3 (PF14603): Helically-extended SH3 domain
Eps8l3
interactor100PTB (PF08416): Phosphotyrosine-binding domain
SH3_1 (PF00018): SH3 domain
Gas7
oncogene70.8000.900SH3_9 (PF14604): Variant SH3 domain
WW (PF00397): WW domain
WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
FCH (PF00611): Fes/CIP4, and EFC/F-BAR homology domain
Lectin_N (PF03954): Hepatic lectin, N-terminal domain
DUF1664 (PF07889): Protein of unknown function (DUF1664)
YscO (PF07321): Type III secretion protein YscO
Homer3
interactor61.0000WH1 (PF00568): WH1 domain
Sec66 (PF09802): Preprotein translocase subunit Sec66
Spc7 (PF08317): Spc7 kinetochore protein
Cep57_CLD_2 (PF14197): Centrosome localisation domain of PPC89
MerR-DNA-bind (PF09278): MerR, DNA binding
Ikbip
interactor21.0000PspB (PF06667): Phage shock protein B
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
COG2 (PF06148): COG (conserved oligomeric Golgi) complex component, COG2
Kiaa1522
interactor50.7001.100Hamartin (PF04388): Hamartin protein
NHS (PF15273): NHS-like
Lhx4
tumor suppressor50.9000.100LIM (PF00412): LIM domain
Homeobox (PF00046): Homeobox domain
Mki67
interactor100SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
PP1_bind (PF15276): Protein phosphatase 1 binding
DUF1777 (PF08648): Protein of unknown function (DUF1777)
K167R (PF08065): K167R (NUC007) repeat
Suf (PF05843): Suppressor of forked protein (Suf)
Nck1
oncogene80.6077.067SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nck2
interactor190.43155.256SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain
Nckap1
interactor220.42465.939Nckap1 (PF09735): Membrane-associated apoptosis protein
Nckap1l
interactor50.8000.433Nckap1 (PF09735): Membrane-associated apoptosis protein
Nhs
interactor100NHS (PF15273): NHS-like
Nhsl1
interactor40.8330.222NHS (PF15273): NHS-like
Nhsl2
interactor90.8331.662NHS (PF15273): NHS-like
Odf3l2
interactor100RNA_pol_Rpb1_R (PF05001): RNA polymerase Rpb1 C-terminal repeat
SHIPPO-rpt (PF07004): Sperm-tail PG-rich repeat
Pcmt1
interactor21.0000PCMT (PF01135): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
Pik3r1
oncogene61.0000SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Ppp2r1a
oncogene100HEAT_2 (PF13646): HEAT repeats
HEAT_PBS (PF03130): PBS lyase HEAT-like repeat
HEAT (PF02985): HEAT repeat
TAF6_C (PF07571): TAF6 C-terminal HEAT repeat domain
Prkaa1
tumor suppressor31.0000Pkinase (PF00069): Protein kinase domain
AdenylateSensor (PF16579): Adenylate sensor of SNF1-like protein kinase
Prpf40a
interactor100.47212.178SOBP (PF15279): Sine oculis-binding protein
WW (PF00397): WW domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF2058 (PF09831): Uncharacterized protein conserved in bacteria (DUF2058)
FF (PF01846): FF domain
YqzE (PF14038): YqzE-like protein
RSB_motif (PF16294): RNSP1-SAP18 binding (RSB) motif
U79_P34 (PF03064): HSV U79 / HCMV P34
Chorion_2 (PF03964): Chorion family 2
SRRM_C (PF15230): Serine/arginine repetitive matrix protein C-terminus
Ryk
interactor, oncogene70.8570.587WIF (PF02019): WIF domain
SID-1_RNA_chan (PF13965): dsRNA-gated channel SID-1
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Sf3a3
interactor50.7001.186SF3a60_bindingd (PF12108): Splicing factor SF3a60 binding domain
SF3A3 (PF16837): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
DUF3449 (PF11931): Domain of unknown function (DUF3449)
Sos1
oncogene100.40024.333Histone (PF00125): Core histone H2A/H2B/H3/H4
RhoGEF (PF00621): RhoGEF domain
DUF445 (PF04286): Protein of unknown function (DUF445)
PH (PF00169): PH domain
RasGEF_N (PF00618): RasGEF N-terminal motif
RasGEF (PF00617): RasGEF domain
Srrm1
interactor30.6671.000PWI (PF01480): PWI domain
MAP65_ASE1 (PF03999): Microtubule associated protein (MAP65/ASE1 family)
TLP-20 (PF06088): Nucleopolyhedrovirus telokin-like protein-20 (TLP20)
DUF755 (PF05501): Domain of unknown function (DUF755)
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
TERB2 (PF15101): Telomere-associated protein TERB2
Hepatitis_core (PF00906): Hepatitis core antigen
ETRAMP (PF09716): Malarial early transcribed membrane protein (ETRAMP)
FAM176 (PF14851): FAM176 family
Ssb
interactor21.0000La (PF05383): La domain
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_3 (PF08777): RNA binding motif
Tcerg1
interactor60.7331.500WW (PF00397): WW domain
DUF3807 (PF12720): Protein of unknown function (DUF3807)
Sporozoite_P67 (PF05642): Sporozoite P67 surface antigen
Spore_coat_CotO (PF14153): Spore coat protein CotO
RR_TM4-6 (PF06459): Ryanodine Receptor TM 4-6
FF (PF01846): FF domain
DUF3886 (PF13025): Protein of unknown function (DUF3886)
Folliculin (PF11704): Vesicle coat protein involved in Golgi to plasma membrane transport
Tcf4
tumor suppressor70.9520.143CDC45 (PF02724): CDC45-like protein
HLH (PF00010): Helix-loop-helix DNA-binding domain
MAGE_N (PF12440): Melanoma associated antigen family N terminal
Timm50
interactor110.6915.940NIF (PF03031): NLI interacting factor-like phosphatase
Ubxn11
interactor70.7622.767IncA (PF04156): IncA protein
TRPM_tetra (PF16519): Tetramerisation domain of TRPM
SEP (PF08059): SEP domain
UBX (PF00789): UBX domain
Vasp
interactor80.6194.371WH1 (PF00568): WH1 domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
ASD2 (PF08687): Apx/Shroom domain ASD2
VASP_tetra (PF08776): VASP tetramerisation domain
Wasf1
interactor170.47131.863Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif
Wasf2
oncogene200.40549.634WASH_WAHD (PF11945): WAHD domain of WASH complex
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
WH2 (PF02205): WH2 motif
Wasf3
interactor100.6894.405ChaB (PF06150): ChaB
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
RCDG1 (PF15725): Renal cancer differentiation gene 1 protein
WH2 (PF02205): WH2 motif
Wasl
interactor110.41819.292WH1 (PF00568): WH1 domain
NUP50 (PF08911): NUP50 (Nucleoporin 50 kDa)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
PBD (PF00786): P21-Rho-binding domain
WH2 (PF02205): WH2 motif
Znf511
interactor70.9050.243zf-C2H2_aberr (PF17017): Aberrant zinc-finger
zf-C2H2 (PF00096): Zinc finger, C2H2 type
CHORD (PF04968): CHORD
Znf746
interactor61.0000DUF3669 (PF12417): Zinc finger protein
KRAB (PF01352): KRAB box
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Period_C (PF12114): Period protein 2/3C-terminal region
zf-C2H2_11 (PF16622): zinc-finger C2H2-type

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