Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcg8 (from a repository: Fri Apr 13 00:28:14 2018)
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PPI Properties:

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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins2 (16.67 %)
The number (and %) of the tumor suppressors4 (33.33 %)
Total number of binary PPIs (saturation %)12 (18.18 %)
The number (and %) of affected PPIs11 (91.67 %)
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5222
The network average Clustering coefficient0.168
The number (and %) of a zero Clustering coefficients9 (75.00 %)
The number (and %) of a zero Betweenness Centrality11 (91.67 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcg8
user protein110.018108.000DUF258 (PF03193): Protein of unknown function, DUF258
ABC_tran (PF00005): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
ABC2_membrane (PF01061): ABC-2 type transporter
Abcg5
interactor100ABC_tran (PF00005): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
NTPase_1 (PF03266): NTPase
ATPase_2 (PF01637): ATPase domain predominantly from Archaea
ABC2_membrane (PF01061): ABC-2 type transporter
Agpat2
interactor100DUF4131 (PF13567): Domain of unknown function (DUF4131)
Acyltransferase (PF01553): Acyltransferase
Poly_export (PF02563): Polysaccharide biosynthesis/export protein
Akt2
oncogene100PH (PF00169): PH domain
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Ang
oncogene100RnaseA (PF00074): Pancreatic ribonuclease
Lmnb1
interactor100Filament (PF00038): Intermediate filament protein
LTD (PF00932): Lamin Tail Domain
Notch3
oncogene, tumor suppressor21.0000EGF (PF00008): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
hEGF (PF12661): Human growth factor-like EGF
EGF_alliinase (PF04863): Alliinase EGF-like domain
Notch (PF00066): LNR domain
NOD (PF06816): NOTCH protein
NODP (PF07684): NOTCH protein
Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ank_2 (PF12796): Ankyrin repeats (3 copies)
DUF3454 (PF11936): Domain of unknown function (DUF3454)
Nr4a1
tumor suppressor100SR-25 (PF10500): Nuclear RNA-splicing-associated protein
zf-C4 (PF00105): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Nupr1
tumor suppressor100Phospho_p8 (PF10195): DNA-binding nuclear phosphoprotein p8
Ptprd
oncogene, tumor suppressor100I-set (PF07679): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
Glyco_hydro_46 (PF01374): Glycosyl hydrolase family 46
Tmem184b
interactor100Solute_trans_a (PF03619): Organic solute transporter Ostalpha
Tspan3
interactor21.0000Tetraspannin (PF00335): Tetraspanin family
Hum_adeno_E3A (PF05393): Human adenovirus early E3A glycoprotein

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