Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcf2 (from a repository: Sat Apr 14 17:12:44 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins4 (9.09 %)
The number (and %) of the tumor suppressors8 (18.18 %)
Total number of binary PPIs (saturation %)162 (17.12 %)
The number (and %) of affected PPIs43 (26.54 %)
PPI diameter2
PPI radius1
The average degree of PPI6.682
Assortativity coefficient-0.4145
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients3 (6.82 %)
The number (and %) of a zero Betweenness Centrality10 (22.73 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcf2
user protein430.1151079.371VIT1 (PF01988): VIT family
ABC_tran (PF00005): ABC transporter
Rop (PF01815): Rop protein
AAA_24 (PF13479): AAA domain
ABC_tran_Xtn (PF12848): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
Acad9
interactor30.6670.500Acyl-CoA_dh_N (PF02771): Acyl-CoA dehydrogenase, N-terminal domain
Acyl-CoA_dh_M (PF02770): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1 (PF00441): Acyl-CoA dehydrogenase, C-terminal domain
Ahcyl1
tumor suppressor40.6671.000Big_3_5 (PF16640): Bacterial Ig-like domain (group 3)
DUF515 (PF04415): Protein of unknown function (DUF515)
AdoHcyase (PF05221): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Ahcyl2
interactor60.5003.622SR-25 (PF10500): Nuclear RNA-splicing-associated protein
AdoHcyase (PF05221): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Brca1
oncogene, tumor suppressor70.4007.067zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
S36_mt (PF10937): Ribosomal protein S36, mitochondrial
BRCT_assoc (PF12820): Serine-rich domain associated with BRCT
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Ccnl2
interactor100Cyclin_N (PF00134): Cyclin, N-terminal domain
Cyclin_C (PF02984): Cyclin, C-terminal domain
Transformer (PF06495): Fruit fly transformer protein
PRP38_assoc (PF12871): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Cluh
interactor21.0000CLU_N (PF15044): Mitochondrial function, CLU-N-term
DUF727 (PF05303): Protein of unknown function (DUF727)
CLU (PF13236): Clustered mitochondria
eIF3_p135 (PF12807): Translation initiation factor eIF3 subunit 135
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_10 (PF13374): Tetratricopeptide repeat
Ddx18
interactor90.5838.971DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
DUF4217 (PF13959): Domain of unknown function (DUF4217)
Dkc1
oncogene100.5569.915DKCLD (PF08068): DKCLD (NUC011) domain
TruB_N (PF01509): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198): tRNA pseudouridylate synthase B C-terminal domain
PUA (PF01472): PUA domain
DUF2992 (PF11208): Protein of unknown function (DUF2992)
Dnaja2
interactor60.7331.889DnaJ (PF00226): DnaJ domain
DnaJ_C (PF01556): DnaJ C terminal domain
Efl1
interactor21.0000GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
EFG_II (PF14492): Elongation Factor G, domain II
EFG_IV (PF03764): Elongation factor G, domain IV
EFG_C (PF00679): Elongation factor G C-terminus
Eif2s3
interactor30.6670.182GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
eIF2_C (PF09173): Initiation factor eIF2 gamma, C terminal
Eif5b
interactor40.6671.400DUF4710 (PF15828): Domain of unknown function (DUF4710)
Coilin_N (PF15862): Coilin N-terminus
TMEMspv1-c74-12 (PF11044): Plectrovirus spv1-c74 ORF 12 transmembrane protein
DUF4632 (PF15451): Domain of unknown function (DUF4632)
MIase (PF02426): Muconolactone delta-isomerase
FGF-BP1 (PF06473): FGF binding protein 1 (FGF-BP1)
NOA36 (PF06524): NOA36 protein
Apt1 (PF10351): Golgi-body localisation protein domain
GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
DUF913 (PF06025): Domain of Unknown Function (DUF913)
IF-2 (PF11987): Translation-initiation factor 2
DUF3306 (PF11748): Protein of unknown function (DUF3306)
GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4
Faf2
interactor60.6002.733UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
DUF1682 (PF07946): Protein of unknown function (DUF1682)
UBX (PF00789): UBX domain
Fus
oncogene, tumor suppressor80.5367.567Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Hadha
interactor21.0000ECH_1 (PF00378): Enoyl-CoA hydratase/isomerase
3HCDH_N (PF02737): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
3HCDH (PF00725): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Hnrnpa2b1
oncogene60.3336.289RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Ilk
tumor suppressor70.4005.467Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Isg15
tumor suppressor40.5002.000ubiquitin (PF00240): Ubiquitin family
LOC103724776
interactor60.5333.633TPR_1 (PF00515): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
PPP5 (PF08321): PPP5 TPR repeat region
Metallophos (PF00149): Calcineurin-like phosphoesterase
LOC103732819
interactor110.30925.800F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region
LOC103748852
interactor90.5717.456Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Mad2l1
oncogene200HORMA (PF02301): HORMA domain
Mov10
interactor60.5333.515AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
Mthfd1
interactor50.6001.789THF_DHG_CYH (PF00763): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
FTHFS (PF01268): Formate--tetrahydrofolate ligase
Nat10
interactor80.6435.748DUF1726 (PF08351): Domain of unknown function (DUF1726)
Helicase_RecD (PF05127): Helicase
GNAT_acetyltr_2 (PF13718): GNAT acetyltransferase 2
tRNA_bind_2 (PF13725): Possible tRNA binding domain
Nop56
interactor120.37924.367NOP5NT (PF08156): NOP5NT (NUC127) domain
Nop (PF01798): snoRNA binding domain, fibrillarin
DUF2656 (PF10847): Protein of unknown function (DUF2656)
Npm1
tumor suppressor160.34351.371Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285): SDA1
NPM1-C (PF16276): Nucleophosmin C-terminal domain
Ntrk1
oncogene300.143305.600LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nudcd1
interactor31.0000CS (PF04969): CS domain
Nxf1
interactor100.33317.300Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Otub1
interactor50.9000.500Peptidase_C65 (PF10275): Peptidase C65 Otubain
Phf12
interactor31.0000PHD (PF00628): PHD-finger
PHF12_MRG_bd (PF16737): PHD finger protein 12 MRG binding domain
FHA (PF00498): FHA domain
Polr1c
interactor51.0000RNA_pol_A_bac (PF01000): RNA polymerase Rpb3/RpoA insert domain
Ppp1r10
interactor40.6670.500Med26 (PF08711): TFIIS helical bundle-like domain
zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Ptges2
interactor200RskA (PF10099): Anti-sigma-K factor rskA
GST_N_3 (PF13417): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
Rpl10
oncogene, tumor suppressor70.7621.848Ribosomal_L16 (PF00252): Ribosomal protein L16p/L10e
Rpl6
interactor60.6672.071Ribosomal_L6e_N (PF03868): Ribosomal protein L6, N-terminal domain
Ribosomal_L6e (PF01159): Ribosomal protein L6e
Shmt2
interactor60.5333.348SHMT (PF00464): Serine hydroxymethyltransferase
Sirt6
tumor suppressor30.6671.000SIR2 (PF02146): Sir2 family
TPP_enzyme_M (PF00205): Thiamine pyrophosphate enzyme, central domain
Tm9sf4
interactor30.6671.000EMP70 (PF02990): Endomembrane protein 70
DUF4229 (PF14012): Protein of unknown function (DUF4229)
Upf2
interactor41.0000Upf2 (PF04050): Up-frameshift suppressor 2
Wdr36
interactor60.8670.682WD40 (PF00400): WD domain, G-beta repeat
WD40_like (PF17005): WD40-like domain
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Utp21 (PF04192): Utp21 specific WD40 associated putative domain
Zc3h15
interactor40.5002.500zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131): Torus domain
DFRP_C (PF16543): DRG Family Regulatory Proteins, Tma46

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