Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcf1 (from a repository: Sat Apr 28 11:44:41 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins11 (21.15 %)
The number (and %) of the tumor suppressors2 (3.85 %)
Total number of binary PPIs (saturation %)391 (29.49 %)
The number (and %) of affected PPIs51 (13.04 %)
PPI diameter2
PPI radius1
The average degree of PPI14.423
Assortativity coefficient-0.2001
The network average Clustering coefficient0.604
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality2 (3.85 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcf1
user protein510.254797.935Rrp15p (PF07890): Rrp15p
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
ABC_tran_Xtn (PF12848): ABC transporter
ABC_tran (PF00005): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
Spt20 (PF12090): Spt20 family
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
Abce1
interactor110.5338.828RLI (PF04068): Possible Fer4-like domain in RNase L inhibitor, RLI
Fer4 (PF00037): 4Fe-4S binding domain
Fer4_7 (PF12838): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
App
interactor160.26747.462APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
CUNH14orf166
interactor200.64217.293RLL (PF10036): Putative carnitine deficiency-associated protein
Cnot1
interactor50.8000.299CNOT1_CAF1_bind (PF16415): CCR4-NOT transcription complex subunit 1 CAF1-binding domain
EF-hand_8 (PF13833): EF-hand domain pair
CNOT1_HEAT (PF16418): CCR4-NOT transcription complex subunit 1 HEAT repeat
Auts2 (PF15336): Autism susceptibility gene 2 protein
CNOT1_TTP_bind (PF16417): CCR4-NOT transcription complex subunit 1 TTP binding domain
DUF3439 (PF11921): Domain of unknown function (DUF3439)
DUF3819 (PF12842): Domain of unknown function (DUF3819)
Not1 (PF04054): CCR4-Not complex component, Not1
Cops5
interactor180.59614.172JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Cul2
tumor suppressor140.62612.264Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddx1
oncogene260.57242.976DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Dync1i2
interactor80.6434.706Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
YqfQ (PF14181): YqfQ-like protein
Dynein_IC2 (PF11540): Cytoplasmic dynein 1 intermediate chain 2
DUF2052 (PF09747): Coiled-coil domain containing protein (DUF2052)
WD40 (PF00400): WD domain, G-beta repeat
DUF4329 (PF14220): Domain of unknown function (DUF4329)
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Edc4
interactor100.6892.861Ge1_WD40 (PF16529): WD40 region of Ge1, enhancer of mRNA-decapping protein
DUF4667 (PF15700): Domain of unknown function (DUF4667)
IMUP (PF15761): Immortalisation up-regulated protein
DUF445 (PF04286): Protein of unknown function (DUF445)
FAM104 (PF15434): Family 104
Eed
tumor suppressor130.5916.928WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nup160 (PF11715): Nucleoporin Nup120/160
Eif2b2
interactor180.66013.737IF-2B (PF01008): Initiation factor 2 subunit family
Eif2b3
interactor170.7507.328NTP_transferase (PF00483): Nucleotidyl transferase
NAGPA (PF09992): Phosphodiester glycosidase
CTP_transf_3 (PF02348): Cytidylyltransferase
Hexapep (PF00132): Bacterial transferase hexapeptide (six repeats)
DUF4954 (PF16314): Domain of unknown function (DUF4954)
Eif6
interactor80.6072.652eIF-6 (PF01912): eIF-6 family
Emc2
interactor31.0000TPR_19 (PF14559): Tetratricopeptide repeat
TPR_9 (PF13371): Tetratricopeptide repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_11 (PF13414): TPR repeat
Alkyl_sulf_dimr (PF14863): Alkyl sulfatase dimerisation
TPR_8 (PF13181): Tetratricopeptide repeat
Fkbp3
interactor130.8851.656FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
Fmnl1
interactor30.6670.500FAP (PF07174): Fibronectin-attachment protein (FAP)
Drf_GBD (PF06371): Diaphanous GTPase-binding Domain
Drf_FH3 (PF06367): Diaphanous FH3 Domain
ABC_tran_CTD (PF16326): ABC transporter C-terminal domain
FH2 (PF02181): Formin Homology 2 Domain
Phage_GPO (PF05929): Phage capsid scaffolding protein (GPO) serine peptidase
DUF4407 (PF14362): Domain of unknown function (DUF4407)
Fn1
oncogene200.43248.938fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Fryl
oncogene40.6671.500MOR2-PAG1_N (PF14222): Cell morphogenesis N-terminal
MOR2-PAG1_mid (PF14228): Cell morphogenesis central region
MOR2-PAG1_C (PF14225): Cell morphogenesis C-terminal
Grk5
interactor70.4675.467RGS (PF00615): Regulator of G protein signaling domain
Pkinase (PF00069): Protein kinase domain
Hdgf
interactor50.7000.850PWWP (PF00855): PWWP domain
Hnrnpa0
interactor150.50522.345RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Hnrnpa2b1
oncogene170.53723.115RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Hnrnpm
interactor190.59117.065HnRNP_M (PF11532): Heterogeneous nuclear ribonucleoprotein M
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Collagen_mid (PF15984): Bacterial collagen, middle region
Hnrnpu
interactor300.47688.172SAP (PF02037): SAP domain
Nop14 (PF04147): Nop14-like family
SPRY (PF00622): SPRY domain
AAA_33 (PF13671): AAA domain
Igf2bp3
interactor230.61727.592RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013): KH domain
KH_4 (PF13083): KH domain
Ilf2
interactor230.58527.365DZF (PF07528): DZF domain
LOC103739764
interactor230.49446.883Helicase_C (PF00271): Helicase conserved C-terminal domain
HA2 (PF04408): Helicase associated domain (HA2)
OB_NTP_bind (PF07717): Oligonucleotide/oligosaccharide-binding (OB)-fold
Map2
oncogene100.5567.891RII_binding_1 (PF10522): RII binding domain
MAP2_projctn (PF08377): MAP2/Tau projection domain
Tubulin-binding (PF00418): Tau and MAP protein, tubulin-binding repeat
Mcm2
oncogene210.48938.888MCM2_N (PF12619): Mini-chromosome maintenance protein 2
MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
AAA_3 (PF07726): ATPase family associated with various cellular activities (AAA)
MCM (PF00493): MCM2/3/5 family
Mms19
interactor90.47214.443MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
DUF3437 (PF11919): Domain of unknown function (DUF3437)
HEAT (PF02985): HEAT repeat
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
Mre11
oncogene210.67914.521Metallophos (PF00149): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152): Mre11 DNA-binding presumed domain
APG6 (PF04111): Autophagy protein Apg6
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
Nelfb
interactor140.8722.192COBRA1 (PF06209): Cofactor of BRCA1 (COBRA1)
Nmt1
oncogene200.67918.080NST1 (PF13945): Salt tolerance down-regulator
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
NMT (PF01233): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Nop56
interactor120.6525.380NOP5NT (PF08156): NOP5NT (NUC127) domain
Nop (PF01798): snoRNA binding domain, fibrillarin
DUF2656 (PF10847): Protein of unknown function (DUF2656)
Ntrk1
oncogene370.292289.591LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Obsl1
interactor190.50322.215I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Otub1
interactor30.6670.154Peptidase_C65 (PF10275): Peptidase C65 Otubain
Psmc5
interactor90.6436.015RILP (PF11461): Rab interacting lysosomal protein
Laminin_II (PF06009): Laminin Domain II
AAA_16 (PF13191): AAA ATPase domain
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Psmc6
interactor80.5716.351TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450): Proteasomal ATPase OB/ID domain
AAA_2 (PF07724): AAA domain (Cdc48 subfamily)
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Psmd7
interactor51.0000JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012): Maintenance of mitochondrial structure and function
Connexin (PF00029): Connexin
Psmd8
interactor90.6397.067CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
Ptbp1
oncogene160.56212.224RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rfc4
interactor220.58933.994Rad17 (PF03215): Rad17 cell cycle checkpoint protein
AAA (PF00004): ATPase family associated with various cellular activities (AAA)
AAA_assoc_2 (PF16193): AAA C-terminal domain
Rep_fac_C (PF08542): Replication factor C C-terminal domain
Rnf2
interactor170.31744.780zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Rpl27a
interactor100.6004.544Ribosomal_L27A (PF00828): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Rtcb
interactor200.69512.499RtcB (PF01139): tRNA-splicing ligase RtcB
Sirt7
interactor140.33033.035DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Sub1
interactor50.8330.333PC4 (PF02229): Transcriptional Coactivator p15 (PC4)
Tbl1xr1
oncogene40.8330.154LisH (PF08513): LisH
Nucleoporin_N (PF08801): Nup133 N terminal like
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
WD40 (PF00400): WD domain, G-beta repeat
Ubxn7
interactor40.6670.750UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UIM (PF02809): Ubiquitin interaction motif
Spt5_N (PF11942): Spt5 transcription elongation factor, acidic N-terminal
UBX (PF00789): UBX domain
Xpo1
interactor170.43436.012IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal

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