Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcd3 (from a repository: Sun Apr 22 02:00:34 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins7 (13.21 %)
The number (and %) of the tumor suppressors3 (5.66 %)
Total number of binary PPIs (saturation %)161 (11.68 %)
The number (and %) of affected PPIs52 (32.30 %)
PPI diameter2
PPI radius1
The average degree of PPI5.434
Assortativity coefficient-0.4024
The network average Clustering coefficient0.583
The number (and %) of a zero Clustering coefficients7 (13.21 %)
The number (and %) of a zero Betweenness Centrality24 (45.28 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcd3
user protein520.0692164.433ABC_membrane_2 (PF06472): ABC transporter transmembrane region 2
ABC_tran (PF00005): ABC transporter
Abcd1
interactor70.42910.667ABC_membrane_2 (PF06472): ABC transporter transmembrane region 2
ABC_tran (PF00005): ABC transporter
Agps
interactor31.0000FAD_binding_4 (PF01565): FAD binding domain
FAD-oxidase_C (PF02913): FAD linked oxidases, C-terminal domain
Atp6v1c1
interactor200V-ATPase_C (PF03223): V-ATPase subunit C
Brf2
interactor100TF_Zn_Ribbon (PF08271): TFIIB zinc-binding
DUF2850 (PF11012): Protein of unknown function (DUF2850)
TFIIB (PF00382): Transcription factor TFIIB repeat
T3SS_needle_E (PF08988): Type III secretion system, cytoplasmic E component of needle
Btrc
oncogene41.0000Beta-TrCP_D (PF12125): D domain of beta-TrCP
F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Cln3
interactor100CLN3 (PF02487): CLN3 protein
Coq9
interactor60.4004.333COQ9 (PF08511): COQ9
Ctdnep1
interactor40.6672.000NIF (PF03031): NLI interacting factor-like phosphatase
Cul3
interactor100.27820.067Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Dyrk1a
oncogene50.6671.667DUF755 (PF05501): Domain of unknown function (DUF755)
Pkinase (PF00069): Protein kinase domain
FAM199X (PF15814): Protein family FAM199X
Filament_head (PF04732): Intermediate filament head (DNA binding) region
Dyrk1b
oncogene200Pkinase (PF00069): Protein kinase domain
Herpes_capsid (PF06112): Gammaherpesvirus capsid protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Ect2
oncogene, tumor suppressor21.0000PTCB-BRCT (PF12738): twin BRCT domain
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
PGBA_C (PF15437): Plasminogen-binding protein pgbA C-terminal
RhoGEF (PF00621): RhoGEF domain
Eef2
interactor80.32115.567GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
EFG_II (PF14492): Elongation Factor G, domain II
EFG_IV (PF03764): Elongation factor G, domain IV
EFG_C (PF00679): Elongation factor G C-terminus
Faf2
interactor100.27819.633UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
DUF1682 (PF07946): Protein of unknown function (DUF1682)
UBX (PF00789): UBX domain
Golt1b
interactor41.0000Got1 (PF04178): Got1/Sft2-like family
Hipk4
interactor21.0000Pkinase (PF00069): Protein kinase domain
LOC103746864
interactor31.0000PKD_channel (PF08016): Polycystin cation channel
PTPlike_phytase (PF14566): Inositol hexakisphosphate
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
LOC103748852
interactor100.33320.000Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Mest
interactor100REV (PF00424): REV protein (anti-repression trans-activator protein)
Abhydrolase_1 (PF00561): alpha/beta hydrolase fold
Mlf2
interactor40.6671.667Mlf1IP (PF10248): Myelodysplasia-myeloid leukemia factor 1-interacting protein
Mms19
interactor70.4299.800MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
DUF3437 (PF11919): Domain of unknown function (DUF3437)
HEAT (PF02985): HEAT repeat
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
Mpv17
interactor30.6671.000Mpv17_PMP22 (PF04117): Mpv17 / PMP22 family
Mrpl41
interactor100MRP-L27 (PF09809): Mitochondrial ribosomal protein L27
Myh14
interactor21.0000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Ndufa4
interactor120.34527.733B12D (PF06522): NADH-ubiquinone reductase complex 1 MLRQ subunit
Ndufb11
interactor50.9000.400ESSS (PF10183): ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Ndufs4
interactor60.8001.567ETC_C1_NDUFA4 (PF04800): ETC complex I subunit conserved region
Ndufv1
interactor100.51115.133Complex1_51K (PF01512): Respiratory-chain NADH dehydrogenase 51 Kd subunit
SLBB (PF10531): SLBB domain
NADH_4Fe-4S (PF10589): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Nnt
interactor50.4003.500AlaDh_PNT_N (PF05222): Alanine dehydrogenase/PNT, N-terminal domain
AlaDh_PNT_C (PF01262): Alanine dehydrogenase/PNT, C-terminal domain
PNTB (PF02233): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769): 4TM region of pyridine nucleotide transhydrogenase, mitoch
Ntrk1
oncogene130.27343.400LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nxf1
interactor100.27825.000Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Obsl1
interactor31.0000I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Ociad1
interactor90.46414.000OCIA (PF07051): Ovarian carcinoma immunoreactive antigen (OCIA)
Pelo
interactor40.5002.400eRF1_1 (PF03463): eRF1 domain 1
eRF1_2 (PF03464): eRF1 domain 2
eRF1_3 (PF03465): eRF1 domain 3
Pex19
interactor60.4677.167Peptidase_M16_C (PF05193): Peptidase M16 inactive domain
Rod-binding (PF10135): Rod binding protein
Pex19 (PF04614): Pex19 protein family
Pex3
interactor31.0000Peroxin-3 (PF04882): Peroxin-3
Psma1
interactor31.0000Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Ptp4a3
oncogene31.0000DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Ptpn1
tumor suppressor40.6672.000Y_phosphatase (PF00102): Protein-tyrosine phosphatase
Rab7a
oncogene, tumor suppressor30.6670.667Ras (PF00071): Ras family
Retreg2
interactor100DUF2786 (PF10979): Protein of unknown function (DUF2786)
INSIG (PF07281): Insulin-induced protein (INSIG)
Reticulon (PF02453): Reticulon
Rnf2
interactor70.4674.567zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Surf1
interactor21.0000SURF1 (PF02104): SURF1 family
Synj2bp
interactor21.0000PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Tap1
oncogene31.0000ABC_membrane (PF00664): ABC transporter transmembrane region
ABC_tran (PF00005): ABC transporter
Timmdc1
interactor70.5246.167Tim17 (PF02466): Tim17/Tim22/Tim23/Pmp24 family
TraT (PF05818): Enterobacterial TraT complement resistance protein
Tmem63b
interactor31.0000RSN1_TM (PF13967): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703): Cytosolic domain of 10TM putative phosphate transporter
RSN1_7TM (PF02714): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932): O-Antigen ligase
DUF4006 (PF13179): Family of unknown function (DUF4006)
Tmem67
interactor21.0000Ephrin_rec_like (PF07699): Putative ephrin-receptor like
NCD3G (PF07562): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064): Thrombomodulin like fifth domain, EGF-like
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Meckelin (PF09773): Meckelin (Transmembrane protein 67)
Tomm40
interactor80.4299.800Porin_3 (PF01459): Eukaryotic porin
Usp32
oncogene21.0000EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_5 (PF13202): EF hand
DUSP (PF06337): DUSP domain
Ubiquitin_3 (PF14836): Ubiquitin-like domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
Vapa
interactor110.34532.667Motile_Sperm (PF00635): MSP (Major sperm protein) domain
DUF972 (PF06156): Protein of unknown function (DUF972)
UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Znf746
interactor40.6671.000DUF3669 (PF12417): Zinc finger protein
KRAB (PF01352): KRAB box
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Period_C (PF12114): Period protein 2/3C-terminal region
zf-C2H2_11 (PF16622): zinc-finger C2H2-type

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