Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcc2 (from a repository: Thu Apr 12 02:12:12 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins3 (7.50 %)
The number (and %) of the tumor suppressors5 (12.50 %)
Total number of binary PPIs (saturation %)73 (9.36 %)
The number (and %) of affected PPIs39 (53.42 %)
PPI diameter2
PPI radius1
The average degree of PPI3.350
Assortativity coefficient-0.3944
The network average Clustering coefficient0.626
The number (and %) of a zero Clustering coefficients8 (20.00 %)
The number (and %) of a zero Betweenness Centrality24 (60.00 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcc2
user protein390.0381391.000DUF805 (PF05656): Protein of unknown function (DUF805)
Zeta_toxin (PF06414): Zeta toxin
ABC_membrane (PF00664): ABC transporter transmembrane region
Sensor (PF13796): Putative sensor
ABC_tran (PF00005): ABC transporter
Atp6v1e1
interactor50.5005.000vATP-synt_E (PF01991): ATP synthase (E/31 kDa) subunit
Azin1
interactor100Orn_Arg_deC_N (PF02784): Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Orn_DAP_Arg_deC (PF00278): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
Chchd2
interactor31.0000DUF2076 (PF09849): Uncharacterized protein conserved in bacteria (DUF2076)
CHCH (PF06747): CHCH domain
Eef1a1
oncogene, tumor suppressor50.5003.000GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143): Elongation factor Tu C-terminal domain
Eif4a1
interactor30.6671.000DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Hspa4
heat shock40.5003.000HSP70 (PF00012): Hsp70 protein
Herpes_ICP4_N (PF03584): Herpesvirus ICP4-like protein N-terminal region
Jup
tumor suppressor30.6671.000Arm (PF00514): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
LOC103737005
interactor40.5003.000Ubiq-Cytc-red_N (PF09165): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921): Ubiquinol cytochrome reductase transmembrane region
Rieske (PF00355): Rieske [2Fe-2S] domain
Mcph1
oncogene, tumor suppressor100PTCB-BRCT (PF12738): twin BRCT domain
MSP (PF01716): Manganese-stabilising protein / photosystem II polypeptide
Spectrin (PF00435): Spectrin repeat
RESP18 (PF14948): RESP18 domain
Microcephalin (PF12258): Microcephalin protein
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
Mmgt1
interactor21.0000MMgT (PF10270): Membrane magnesium transporter
Mrpl23
interactor21.0000Ribosomal_L23 (PF00276): Ribosomal protein L23
Ribosomal_S13_N (PF08069): Ribosomal S13/S15 N-terminal domain
Mrpl24
interactor21.0000KOW (PF00467): KOW motif
ribosomal_L24 (PF17136): Ribosomal proteins 50S L24/mitochondrial 39S L24
Mrpl37
interactor21.0000PDCD9 (PF07147): Mitochondrial 28S ribosomal protein S30 (PDCD9)
Mrpl57
interactor100MRP-63 (PF14978): Mitochondrial ribosome protein 63
Mrps26
interactor30.6671.000MRP-S26 (PF14943): Mitochondrial ribosome subunit S26
Mrps28
interactor21.0000MRP-S35 (PF10246): Mitochondrial ribosomal protein MRP-S35
Mrps35
interactor21.0000MRP-S28 (PF10213): Mitochondrial ribosomal subunit protein
Ndufa10
interactor21.0000dNK (PF01712): Deoxynucleoside kinase
Ndufa2
interactor30.6671.000L51_S25_CI-B8 (PF05047): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Ndufa9
interactor60.33310.000Epimerase (PF01370): NAD dependent epimerase/dehydratase family
RmlD_sub_bind (PF04321): RmlD substrate binding domain
Ndufs8
interactor30.6671.000Fer4_7 (PF12838): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
Nfkb1
oncogene, tumor suppressor31.0000RHD_DNA_bind (PF00554): Rel homology DNA-binding domain
RHD_dimer (PF16179): Rel homology dimerisation domain
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Death (PF00531): Death domain
Oxa1l
interactor31.000060KD_IMP (PF02096): 60Kd inner membrane protein
DUF624 (PF04854): Protein of unknown function, DUF624
Pdzd3
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Picalm
oncogene30.6671.000ANTH (PF07651): ANTH domain
Prr3
interactor100Pox_Ag35 (PF03286): Pox virus Ag35 surface protein
zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Ptrh2
interactor30.6671.000DUF2076 (PF09849): Uncharacterized protein conserved in bacteria (DUF2076)
PTH2 (PF01981): Peptidyl-tRNA hydrolase PTH2
Rdx
interactor21.0000FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
ERM (PF00769): Ezrin/radixin/moesin family
Shank3
interactor100FERM_f0 (PF16511): N-terminal or F0 domain of Talin-head FERM
Ank_2 (PF12796): Ankyrin repeats (3 copies)
SH3_2 (PF07653): Variant SH3 domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Slc30a5
oncogene40.6672.000DUF4199 (PF13858): Protein of unknown function (DUF4199)
Cation_efflux (PF01545): Cation efflux family
Slc9a3r1
oncogene, tumor suppressor31.0000PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
EBP50_C (PF09007): EBP50, C-terminal
Ssr1
interactor30.6671.000TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Iso_dh (PF00180): Isocitrate/isopropylmalate dehydrogenase
Synj2bp
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Tcirg1
oncogene31.0000V_ATPase_I (PF01496): V-type ATPase 116kDa subunit family
Tomm20
interactor21.0000MAS20 (PF02064): MAS20 protein import receptor
RSN1_7TM (PF02714): Calcium-dependent channel, 7TM region, putative phosphate
Tomm22
interactor30.6671.000Tom22 (PF04281): Mitochondrial import receptor subunit Tom22
Tubb3
interactor21.0000Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Ubqln1
interactor200ubiquitin (PF00240): Ubiquitin family
Fur_reg_FbpB (PF13040): Fur-regulated basic protein B
Clathrin-link (PF09268): Clathrin, heavy-chain linker
GIT_CC (PF16559): GIT coiled-coil Rho guanine nucleotide exchange factor
XPC-binding (PF09280): XPC-binding domain
DnaG_DnaB_bind (PF08278): DNA primase DnaG DnaB-binding
UBA (PF00627): UBA/TS-N domain
Vamp2
interactor21.0000PRIMA1 (PF16101): Proline-rich membrane anchor 1
Synaptobrevin (PF00957): Synaptobrevin

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