Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abcb7 (from a repository: Sun Apr 15 08:51:28 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins4 (16.67 %)
The number (and %) of the tumor suppressors1 (4.17 %)
Total number of binary PPIs (saturation %)52 (18.84 %)
The number (and %) of affected PPIs23 (44.23 %)
PPI diameter2
PPI radius1
The average degree of PPI3.500
Assortativity coefficient-0.5425
The network average Clustering coefficient0.647
The number (and %) of a zero Clustering coefficients4 (16.67 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abcb7
user protein230.075430.000ABC_membrane (PF00664): ABC transporter transmembrane region
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
Acat1
interactor31.0000Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
App
interactor70.33310.000APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Atp6v1d
interactor100ATP-synt_D (PF01813): ATP synthase subunit D
Ckb
interactor31.0000ATP-gua_PtransN (PF02807): ATP:guanido phosphotransferase, N-terminal domain
ATP-gua_Ptrans (PF00217): ATP:guanido phosphotransferase, C-terminal catalytic domain
Ckm
interactor31.0000ATP-gua_PtransN (PF02807): ATP:guanido phosphotransferase, N-terminal domain
ATP-gua_Ptrans (PF00217): ATP:guanido phosphotransferase, C-terminal catalytic domain
Coq9
interactor40.6671.000COQ9 (PF08511): COQ9
Eprs
interactor21.0000GST_C (PF00043): Glutathione S-transferase, C-terminal domain
tRNA-synt_1c (PF00749): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950): tRNA synthetases class I (E and Q), anti-codon binding domain
WHEP-TRS (PF00458): WHEP-TRS domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
tRNA-synt_2b (PF00587): tRNA synthetase class II core domain (G, H, P, S and T)
HGTP_anticodon (PF03129): Anticodon binding domain
ProRS-C_1 (PF09180): Prolyl-tRNA synthetase, C-terminal
Faf2
interactor31.0000UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
DUF1682 (PF07946): Protein of unknown function (DUF1682)
UBX (PF00789): UBX domain
Fech
interactor31.0000Ferrochelatase (PF00762): Ferrochelatase
Eapp_C (PF10238): E2F-associated phosphoprotein
Fkbp8
interactor40.6671.000FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
Fis1_TPR_C (PF14853): Fis1 C-terminal tetratricopeptide repeat
Foxs1
interactor21.0000Forkhead (PF00250): Forkhead domain
LOC103750218
interactor40.5003.000Peptidase_M16 (PF00675): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193): Peptidase M16 inactive domain
Mat2a
tumor suppressor31.0000S-AdoMet_synt_N (PF00438): S-adenosylmethionine synthetase, N-terminal domain
S-AdoMet_synt_M (PF02772): S-adenosylmethionine synthetase, central domain
S-AdoMet_synt_C (PF02773): S-adenosylmethionine synthetase, C-terminal domain
Mrpl58
interactor30.6671.000RF-1 (PF00472): RF-1 domain
Ndufa4
interactor31.0000B12D (PF06522): NADH-ubiquinone reductase complex 1 MLRQ subunit
Ndufb6
interactor21.0000NDUF_B6 (PF09782): NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
Ntrk1
oncogene90.28620.000LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Pck1
interactor30.6671.000PEPCK (PF00821): Phosphoenolpyruvate carboxykinase
Pdcd6
oncogene200EF-hand_1 (PF00036): EF hand
EF-hand_8 (PF13833): EF-hand domain pair
EF-hand_7 (PF13499): EF-hand domain pair
Rab2a
oncogene21.0000Ras (PF00071): Ras family
Rpn1
oncogene30.6671.000Ribophorin_I (PF04597): Ribophorin I
DNA_repr_REX1B (PF14966): DNA repair REX1-B
Unk
interactor100Torus (PF16131): Torus domain
zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
NUDE_C (PF04880): NUDE protein, C-terminal conserved region
DUF3450 (PF11932): Protein of unknown function (DUF3450)
MscS_porin (PF12795): Mechanosensitive ion channel porin domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Ybx3
interactor100CSD (PF00313): 'Cold-shock' DNA-binding domain

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