Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abca2 (from a repository: Wed Apr 18 15:54:39 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins5 (27.78 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)24 (15.69 %)
The number (and %) of affected PPIs17 (70.83 %)
PPI diameter2
PPI radius1
The average degree of PPI2.222
Assortativity coefficient-0.6417
The network average Clustering coefficient0.168
The number (and %) of a zero Clustering coefficients14 (77.78 %)
The number (and %) of a zero Betweenness Centrality17 (94.44 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abca2
user protein170.022266.000ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
ABC_tran (PF00005): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732): Domain of unknown function (DUF4162)
Cacna1a
interactor100Fungus-induced (PF10917): Fungus-induced protein
Ion_trans (PF00520): Ion transport protein
PNK3P (PF08645): Polynucleotide kinase 3 phosphatase
GPHH (PF16905): Voltage-dependent L-type calcium channel, IQ-associated
Ca_chan_IQ (PF08763): Voltage gated calcium channel IQ domain
SelP_N (PF04592): Selenoprotein P, N terminal region
Cdk5rap2
interactor100Cnn_1N (PF07989): Centrosomin N-terminal motif 1
FAM76 (PF16046): FAM76 protein
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
BST2 (PF16716): Bone marrow stromal antigen 2
Rho_Binding (PF08912): Rho Binding
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
NPV_P10 (PF05531): Nucleopolyhedrovirus P10 protein
TSC22 (PF01166): TSC-22/dip/bun family
Sec20 (PF03908): Sec20
Pox_A_type_inc (PF04508): Viral A-type inclusion protein repeat
CENP-H (PF05837): Centromere protein H (CENP-H)
GAS (PF13851): Growth-arrest specific micro-tubule binding
bZIP_1 (PF00170): bZIP transcription factor
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
DUF2951 (PF11166): Protein of unknown function (DUF2951)
DUF972 (PF06156): Protein of unknown function (DUF972)
Spc7 (PF08317): Spc7 kinetochore protein
Cltc
oncogene41.0000Clathrin_propel (PF01394): Clathrin propeller repeat
Clathrin-link (PF09268): Clathrin, heavy-chain linker
Clathrin_H_link (PF13838): Clathrin-H-link
Clathrin (PF00637): Region in Clathrin and VPS
Htr3a
interactor100Neur_chan_LBD (PF02931): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
LOC103751618
interactor100Patched (PF02460): Patched family
Lamb3
interactor100Laminin_N (PF00055): Laminin N-terminal (Domain VI)
Laminin_EGF (PF00053): Laminin EGF domain
Prominin (PF05478): Prominin
AAA_23 (PF13476): AAA domain
Laminin_II (PF06009): Laminin Domain II
SesA (PF17107): N-terminal domain on NACHT_NTPase and P-loop NTPases
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
KELK (PF15796): KELK-motif containing domain of MRCK Ser/Thr protein kinase
Lman2l
interactor100Lectin_leg-like (PF03388): Legume-like lectin family
PMP1_2 (PF08114): ATPase proteolipid family
Myc
oncogene200Myc_N (PF01056): Myc amino-terminal region
TFIIE-A_C (PF11521): C-terminal general transcription factor TFIIE alpha
HLH (PF00010): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344): Myc leucine zipper domain
Nxf1
interactor41.0000Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Pcdh1
interactor100Cadherin_2 (PF08266): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
RGCC (PF15151): Response gene to complement 32 protein family
Protocadherin (PF08374): Protocadherin
Pms2
oncogene100HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DNA_mis_repair (PF01119): DNA mismatch repair protein, C-terminal domain
MutL_C (PF08676): MutL C terminal dimerisation domain
Pon2
interactor100Lactonase (PF10282): Lactonase, 7-bladed beta-propeller
Arylesterase (PF01731): Arylesterase
NHL (PF01436): NHL repeat
Rab32
oncogene31.0000Ras (PF00071): Ras family
Rnaseh2b
interactor100RNase_H2-Ydr279 (PF09468): Ydr279p protein family (RNase H2 complex component)
Sdhaf2
oncogene100Sdh5 (PF03937): Flavinator of succinate dehydrogenase
Tmem248
interactor100TMEM219 (PF14940): Transmembrane 219
Ywhah
interactor20014-3-3 (PF00244): 14-3-3 protein

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