Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Abca1 (from a repository: Sun Apr 15 08:16:21 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins5 (31.25 %)
The number (and %) of the tumor suppressors3 (18.75 %)
Total number of binary PPIs (saturation %)25 (20.83 %)
The number (and %) of affected PPIs15 (60.00 %)
PPI diameter2
PPI radius1
The average degree of PPI2.500
Assortativity coefficient-0.6556
The network average Clustering coefficient0.388
The number (and %) of a zero Clustering coefficients8 (50.00 %)
The number (and %) of a zero Betweenness Centrality13 (81.25 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Abca1
user protein, oncogene150.048196.000ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
ABC_tran (PF00005): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732): Domain of unknown function (DUF4162)
Atxn10
interactor100RIH_assoc (PF08454): RyR and IP3R Homology associated
Atx10homo_assoc (PF09759): Spinocerebellar ataxia type 10 protein domain
RYDR_ITPR (PF01365): RIH domain
Cdc42
oncogene200Ras (PF00071): Ras family
Cops2
oncogene, tumor suppressor21.0000TPR_1 (PF00515): Tetratricopeptide repeat
TPR_7 (PF13176): Tetratricopeptide repeat
FliS (PF02561): Flagellar protein FliS
TPR_2 (PF07719): Tetratricopeptide repeat
PCI (PF01399): PCI domain
Cops5
interactor50.5003.000JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Erbin
oncogene200LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Flot1
interactor100Band_7 (PF01145): SPFH domain / Band 7 family
Flot (PF15975): Flotillin
CrtC (PF07143): CrtC N-terminal lipocalin domain
Fus
oncogene, tumor suppressor30.6671.000Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Hgs
interactor21.0000VHS (PF00790): VHS domain
FYVE (PF01363): FYVE zinc finger
UIM (PF02809): Ubiquitin interaction motif
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
DUF3306 (PF11748): Protein of unknown function (DUF3306)
Hrs_helical (PF12210): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917): Piezo
LOC103734495
interactor100Fer2 (PF00111): 2Fe-2S iron-sulfur cluster binding domain
Fer2_2 (PF01799): [2Fe-2S] binding domain
FAD_binding_5 (PF00941): FAD binding domain in molybdopterin dehydrogenase
CO_deh_flav_C (PF03450): CO dehydrogenase flavoprotein C-terminal domain
Ald_Xan_dh_C (PF01315): Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Ald_Xan_dh_C2 (PF02738): Molybdopterin-binding domain of aldehyde dehydrogenase
Nr1h2
oncogene100zf-C4 (PF00105): Zinc finger, C4 type (two domains)
DUF1180 (PF06679): Protein of unknown function (DUF1180)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Prpf8
oncogene200PRO8NT (PF08082): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083): PROCN (NUC071) domain
RRM_4 (PF10598): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596): U6-snRNA interacting domain of PrP8
PRP8_domainIV (PF12134): PRP8 domain IV core
JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PROCT (PF08084): PROCT (NUC072) domain
Rela
oncogene31.0000RHD_DNA_bind (PF00554): Rel homology DNA-binding domain
RHD_dimer (PF16179): Rel homology dimerisation domain
Sdhb
oncogene, tumor suppressor21.0000Fer2_3 (PF13085): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
Sptlc1
interactor100Aminotran_1_2 (PF00155): Aminotransferase class I and II
Stx12
interactor21.0000Syntaxin_2 (PF14523): Syntaxin-like protein
DUF3094 (PF11293): Protein of unknown function (DUF3094)
TMCO5 (PF14992): TMCO5 family
SNARE (PF05739): SNARE domain

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