Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aatf (from a repository: Fri Apr 13 04:55:08 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins9 (16.98 %)
The number (and %) of the tumor suppressors9 (16.98 %)
Total number of binary PPIs (saturation %)235 (17.05 %)
The number (and %) of affected PPIs52 (22.13 %)
PPI diameter2
PPI radius1
The average degree of PPI8.189
Assortativity coefficient-0.3345
The network average Clustering coefficient0.581
The number (and %) of a zero Clustering coefficients4 (7.55 %)
The number (and %) of a zero Betweenness Centrality14 (26.42 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aatf
user protein, oncogene520.1241808.181WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
Vif (PF00559): Retroviral Vif (Viral infectivity) protein
Nop14 (PF04147): Nop14-like family
AATF-Che1 (PF13339): Apoptosis antagonizing transcription factor
Trypan_PARP (PF05887): Procyclic acidic repetitive protein (PARP)
TRAUB (PF08164): Apoptosis-antagonizing transcription factor, C-terminal
Ar
oncogene80.5247.900Androgen_recep (PF02166): Androgen receptor
zf-C4 (PF00105): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Brix1
interactor110.56411.522Brix (PF04427): Brix domain
Btrc
oncogene120.36425.522Beta-TrCP_D (PF12125): D domain of beta-TrCP
F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Cand1
interactor120.50916.118HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
HEAT (PF02985): HEAT repeat
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Adaptin_N (PF01602): Adaptin N terminal region
TIP120 (PF08623): TATA-binding protein interacting (TIP20)
Cdc14b
interactor40.6670.400DSPn (PF14671): Dual specificity protein phosphatase, N-terminal half
PTPlike_phytase (PF14566): Inositol hexakisphosphate
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
DUF442 (PF04273): Putative phosphatase (DUF442)
Cep164
interactor41.0000WW (PF00397): WW domain
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
DUF1777 (PF08648): Protein of unknown function (DUF1777)
PRP1_N (PF06424): PRP1 splicing factor, N-terminal
Mitofilin (PF09731): Mitochondrial inner membrane protein
MAT1 (PF06391): CDK-activating kinase assembly factor MAT1
CwsA (PF10814): Cell wall synthesis protein CwsA
Cauli_AT (PF03233): Aphid transmission protein
Cpd
interactor100Peptidase_M14 (PF00246): Zinc carboxypeptidase
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
Dazap2
interactor40.6671.000DAZAP2 (PF11029): DAZ associated protein 2 (DAZAP2)
Ddx56
interactor130.56414.833DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Ebna1bp2
interactor170.52229.852Ebp2 (PF05890): Eukaryotic rRNA processing protein EBP2
Efnb3
interactor21.0000Ephrin (PF00812): Ephrin
Fbxw11
interactor70.7332.300Beta-TrCP_D (PF12125): D domain of beta-TrCP
F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_N (PF08801): Nup133 N terminal like
Hipk2
oncogene, tumor suppressor50.8330.400Pkinase (PF00069): Protein kinase domain
Kdo (PF06293): Lipopolysaccharide kinase (Kdo/WaaP) family
Hnrnpu
interactor180.35366.171SAP (PF02037): SAP domain
Nop14 (PF04147): Nop14-like family
SPRY (PF00622): SPRY domain
AAA_33 (PF13671): AAA domain
Kri1
interactor70.4766.815Rgp1 (PF08737): Rgp1
NEMP (PF10225): NEMP family
LIN52 (PF10044): Retinal tissue protein
Kri1 (PF05178): KRI1-like family
Kri1_C (PF12936): KRI1-like family C-terminal
Ldoc1
oncogene31.0000DUF4939 (PF16297): Domain of unknown function (DUF4939)
Lin28a
interactor50.6001.586CSD (PF00313): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
Lztr1
oncogene200Kelch_1 (PF01344): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
BTB (PF00651): BTB/POZ domain
BACK (PF07707): BTB And C-terminal Kelch
Sigma70_r3 (PF04539): Sigma-70 region 3
Maged1
interactor60.5003.800Joubert (PF15392): Joubert syndrome-associated
MAGE (PF01454): MAGE family
Mapt
interactor21.0000Tubulin-binding (PF00418): Tau and MAP protein, tubulin-binding repeat
Mdm2
oncogene130.39429.048SWIB (PF02201): SWIB/MDM2 domain
Presenilin (PF01080): Presenilin
DUF4194 (PF13835): Domain of unknown function (DUF4194)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-FPG_IleRS (PF06827): Zinc finger found in FPG and IleRS
Mms19
interactor40.5002.333MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
DUF3437 (PF11919): Domain of unknown function (DUF3437)
HEAT (PF02985): HEAT repeat
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
Mphosph10
interactor100.51111.205Mpp10 (PF04006): Mpp10 protein
Mpp6
interactor100L27 (PF02828): L27 domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653): Variant SH3 domain
Guanylate_kin (PF00625): Guanylate kinase
Nedd4l
oncogene, tumor suppressor50.5002.667C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ngdn
interactor41.0000ZapB (PF06005): Cell division protein ZapB
Sas10_Utp3 (PF04000): Sas10/Utp3/C1D family
TMEM247 (PF15444): Transmembrane protein 247
Noc2l
interactor140.58216.755TFIIE-A_C (PF11521): C-terminal general transcription factor TFIIE alpha
FAM167 (PF11652): FAM167
Noc2 (PF03715): Noc2p family
Nol10
interactor100.42217.121WD40 (PF00400): WD domain, G-beta repeat
NUC153 (PF08159): NUC153 domain
Nol6
interactor110.56410.221Nrap (PF03813): Nrap protein
Nxf1
interactor150.45131.600Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Obsl1
interactor150.58212.159I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Pawr
oncogene, tumor suppressor21.0000Totivirus_coat (PF05518): Totivirus coat protein
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Pcbd2
interactor100Pterin_4a (PF01329): Pterin 4 alpha carbinolamine dehydratase
Pin1
tumor suppressor50.5004.067WW (PF00397): WW domain
Rotamase (PF00639): PPIC-type PPIASE domain
Polr2j
interactor21.0000DUF3405 (PF11885): Protein of unknown function (DUF3405)
RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
SHNi-TPR (PF10516): SHNi-TPR
Pum3
interactor130.64110.341PUF (PF00806): Pumilio-family RNA binding repeat
CPL (PF08144): CPL (NUC119) domain
Bmt2 (PF11968): 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2
EF-G-binding_N (PF07299): Elongation factor G-binding protein, N-terminal
Rb1
oncogene, tumor suppressor31.0000TFIIB (PF00382): Transcription factor TFIIB repeat
DUF3452 (PF11934): Domain of unknown function (DUF3452)
RB_A (PF01858): Retinoblastoma-associated protein A domain
DUF4592 (PF15262): Domain of unknown function (DUF4592)
RB_B (PF01857): Retinoblastoma-associated protein B domain
Rb_C (PF08934): Rb C-terminal domain
Rbl1
oncogene, tumor suppressor40.6672.000RB_B (PF01857): Retinoblastoma-associated protein B domain
DUF3452 (PF11934): Domain of unknown function (DUF3452)
RB_A (PF01858): Retinoblastoma-associated protein A domain
Rb_C (PF08934): Rb C-terminal domain
Rbl2
oncogene, tumor suppressor21.0000TFIIB (PF00382): Transcription factor TFIIB repeat
DUF3452 (PF11934): Domain of unknown function (DUF3452)
SLH (PF00395): S-layer homology domain
RB_A (PF01858): Retinoblastoma-associated protein A domain
RB_B (PF01857): Retinoblastoma-associated protein B domain
Rela
oncogene90.5368.067RHD_DNA_bind (PF00554): Rel homology DNA-binding domain
RHD_dimer (PF16179): Rel homology dimerisation domain
Rpf2
interactor110.6369.494Brix (PF04427): Brix domain
Rpl10
oncogene, tumor suppressor100.6893.983Ribosomal_L16 (PF00252): Ribosomal protein L16p/L10e
Rps2
interactor120.48516.451Ribosomal_S5 (PF00333): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719): Ribosomal protein S5, C-terminal domain
Rps8
interactor120.51515.379Ribosomal_S8e (PF01201): Ribosomal protein S8e
Peptidase_M3_N (PF08439): Oligopeptidase F
Rtel1
oncogene30.6671.000ResIII (PF04851): Type III restriction enzyme, res subunit
DEAD_2 (PF06733): DEAD_2
HBB (PF06777): Helical and beta-bridge domain
Helicase_C_2 (PF13307): Helicase C-terminal domain
CCM2_C (PF16545): Cerebral cavernous malformation protein, harmonin-homology
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
Sirt7
interactor180.41245.765DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Smad3
oncogene100.36120.167MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Ss18l1
oncogene31.0000SSXT (PF05030): SSXT protein (N-terminal region)
DUF1313 (PF07011): Protein of unknown function (DUF1313)
Tsg101
oncogene, tumor suppressor60.7001.833UEV (PF05743): UEV domain
APG6 (PF04111): Autophagy protein Apg6
Vps23_core (PF09454): Vps23 core domain
Wdr36
interactor110.49116.998WD40 (PF00400): WD domain, G-beta repeat
WD40_like (PF17005): WD40-like domain
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Utp21 (PF04192): Utp21 specific WD40 associated putative domain
Xpo1
interactor130.37235.527IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Znf2
interactor50.6001.419KRAB (PF01352): KRAB box
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain

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