Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aarsd1 (from a repository: Sat Apr 21 06:39:06 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins11 (15.07 %)
The number (and %) of the tumor suppressors6 (8.22 %)
Total number of binary PPIs (saturation %)221 (8.41 %)
The number (and %) of affected PPIs72 (32.58 %)
PPI diameter2
PPI radius1
The average degree of PPI5.534
Assortativity coefficient-0.4283
The network average Clustering coefficient0.499
The number (and %) of a zero Clustering coefficients18 (24.66 %)
The number (and %) of a zero Betweenness Centrality31 (42.47 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aarsd1
user protein720.0514430.489tRNA-synt_2c (PF01411): tRNA synthetases class II (A)
tRNA_SAD (PF07973): Threonyl and Alanyl tRNA synthetase second additional domain
Alkbh2
interactor1002OG-FeII_Oxy_2 (PF13532): 2OG-Fe(II) oxygenase superfamily
Apaf1
oncogene, tumor suppressor100CARD (PF00619): Caspase recruitment domain
NB-ARC (PF00931): NB-ARC domain
WD40 (PF00400): WD domain, G-beta repeat
Nbas_N (PF15492): Neuroblastoma-amplified sequence, N terminal
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nup160 (PF11715): Nucleoporin Nup120/160
Arpc1a
interactor100.6447.756WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Arpc2
interactor120.43924.067Vps4_C (PF09336): Vps4 C terminal oligomerisation domain
P34-Arc (PF04045): Arp2/3 complex, 34 kD subunit p34-Arc
Arpc5
interactor70.6195.222P16-Arc (PF04699): ARP2/3 complex 16 kDa subunit (p16-Arc)
Bora
interactor100BORA_N (PF15280): Protein aurora borealis N-terminus
Brca2
oncogene, tumor suppressor50.5005.000Cupin_8 (PF13621): Cupin-like domain
BRCA2 (PF00634): BRCA2 repeat
BRCA-2_helical (PF09169): BRCA2, helical
BRCA-2_OB1 (PF09103): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
Tower (PF09121): Tower
BRCA-2_OB3 (PF09104): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
Calr
oncogene120.45518.533Calreticulin (PF00262): Calreticulin family
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
Calu
interactor160.35057.922EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_8 (PF13833): EF-hand domain pair
Ddhd2
interactor100WWE (PF02825): WWE domain
DUF676 (PF05057): Putative serine esterase (DUF676)
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
DDHD (PF02862): DDHD domain
Dynlt1
interactor50.4004.500Tctex-1 (PF03645): Tctex-1 family
Eftud2
interactor90.53612.333EFTUD2 (PF16004): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
EFG_II (PF14492): Elongation Factor G, domain II
EFG_IV (PF03764): Elongation factor G, domain IV
EFG_C (PF00679): Elongation factor G C-terminus
Ercc6l
interactor30.6671.000TPR_2 (PF07719): Tetratricopeptide repeat
SNF2_N (PF00176): SNF2 family N-terminal domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
TPR_11 (PF13414): TPR repeat
Fam83h
interactor21.0000DUF1669 (PF07894): Protein of unknown function (DUF1669)
PLDc_2 (PF13091): PLD-like domain
Fbxo7
interactor100YukD (PF08817): WXG100 protein secretion system (Wss), protein YukD
PI31_Prot_N (PF11566): PI31 proteasome regulator N-terminal
F-box-like (PF12937): F-box-like
Elongin_A (PF06881): RNA polymerase II transcription factor SIII (Elongin) subunit A
Fignl1
interactor100AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336): Vps4 C terminal oligomerisation domain
Fubp1
oncogene60.6672.867KH_1 (PF00013): KH domain
DUF1897 (PF09005): Domain of unknown function (DUF1897)
CYSTM (PF12734): Cysteine-rich TM module stress tolerance
Gtf2e1
interactor50.9000.333TFIIE_alpha (PF02002): TFIIE alpha subunit
TF_Zn_Ribbon (PF08271): TFIIB zinc-binding
TFIIE-A_C (PF11521): C-terminal general transcription factor TFIIE alpha
Hars
interactor70.4769.000WHEP-TRS (PF00458): WHEP-TRS domain
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
Sugarporin_N (PF11471): Maltoporin periplasmic N-terminal extension
HGTP_anticodon (PF03129): Anticodon binding domain
Hectd1
interactor40.6670.500Arm (PF00514): Armadillo/beta-catenin-like repeat
DUF4926 (PF16277): Domain of unknown function (DUF4926)
Ank_2 (PF12796): Ankyrin repeats (3 copies)
CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
Sad1_UNC (PF07738): Sad1 / UNC-like C-terminal
MIB_HERC2 (PF06701): Mib_herc2
NOA36 (PF06524): NOA36 protein
Cwf_Cwc_15 (PF04889): Cwf15/Cwc15 cell cycle control protein
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Hook1
interactor200HOOK (PF05622): HOOK protein
Hps5
interactor100ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Hspb1
heat shock, oncogene120.32733.067HSP20 (PF00011): Hsp20/alpha crystallin family
Irs4
interactor40.6671.667TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
IRS (PF02174): PTB domain (IRS-1 type)
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Jade2
interactor100EPL1 (PF10513): Enhancer of polycomb-like
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
PRA-PH (PF01503): Phosphoribosyl-ATP pyrophosphohydrolase
Kif1a
interactor21.0000Kinesin (PF00225): Kinesin motor domain
Kinesin_assoc (PF16183): Kinesin-associated
FHA (PF00498): FHA domain
IncA (PF04156): IncA protein
KIF1B (PF12423): Kinesin protein 1B
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF3694 (PF12473): Kinesin protein
PH (PF00169): PH domain
LOC108491685
interactor70.5245.467CTK3 (PF12243): CTD kinase subunit gamma CTK3
CTD_bind (PF04818): RNA polymerase II-binding domain.
Lap3
interactor50.7002.667Peptidase_M17_N (PF02789): Cytosol aminopeptidase family, N-terminal domain
DUF1327 (PF07041): Protein of unknown function (DUF1327)
Peptidase_M17 (PF00883): Cytosol aminopeptidase family, catalytic domain
Luzp1
interactor30.6670.500Trimer_CC (PF08954): Trimerisation motif
BAAT_C (PF08840): BAAT / Acyl-CoA thioester hydrolase C terminal
DUF4298 (PF14131): Domain of unknown function (DUF4298)
EMP24_GP25L (PF01105): emp24/gp25L/p24 family/GOLD
HD_assoc (PF13286): Phosphohydrolase-associated domain
Fzo_mitofusin (PF04799): fzo-like conserved region
TMA7 (PF09072): Translation machinery associated TMA7
Map3k7
oncogene40.6671.000Pkinase_Tyr (PF07714): Protein tyrosine kinase
Mnd1 (PF03962): Mnd1 family
Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain
Mlf1
oncogene60.33310.000Mlf1IP (PF10248): Myelodysplasia-myeloid leukemia factor 1-interacting protein
Nif3l1
interactor110.42218.700NIF3 (PF01784): NIF3 (NGG1p interacting factor 3)
Parvg
interactor100REV1_C (PF16727): DNA repair protein REV1 C-terminal domain
CH (PF00307): Calponin homology (CH) domain
Pfdn1
interactor50.6003.500Prefoldin_2 (PF01920): Prefoldin subunit
Pfdn5
interactor100.42218.122UPF0693 (PF16088): UPF0693 family
Prefoldin (PF02996): Prefoldin subunit
Poc5
interactor21.0000zf-C4H2 (PF10146): Zinc finger-containing protein
MbeD_MobD (PF04899): MbeD/MobD like
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
Kinetocho_Slk19 (PF12709): Central kinetochore-associated
Ppp1r12a
interactor50.8001.167Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
Mucin (PF01456): Mucin-like glycoprotein
PPP4R2 (PF09184): PPP4R2
FAM60A (PF15396): Protein Family FAM60A
DUF3682 (PF12446): Protein of unknown function (DUF3682)
MAP17 (PF15807): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
Connexin (PF00029): Connexin
Pannexin_like (PF12534): Pannexin-like TM region of LRRC8
PRKG1_interact (PF15898): cGMP-dependent protein kinase interacting domain
Ppp2cb
interactor, tumor suppressor40.6671.667STPPase_N (PF16891): Serine-threonine protein phosphatase N-terminal domain
Metallophos (PF00149): Calcineurin-like phosphoesterase
Prkaca
interactor120.41825.089Pkinase (PF00069): Protein kinase domain
Rad21
oncogene70.42910.400Rad21_Rec8_N (PF04825): N terminus of Rad21 / Rec8 like protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
Rad21_Rec8 (PF04824): Conserved region of Rad21 / Rec8 like protein
Rgs20
interactor21.0000RGS (PF00615): Regulator of G protein signaling domain
Rhoj
interactor100Ras (PF00071): Ras family
P12 (PF12669): Virus attachment protein p12 family
Ric8b
interactor100Ric8 (PF10165): Guanine nucleotide exchange factor synembryn
Rictor
interactor30.6671.000RICTOR_N (PF14664): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_M (PF14666): Rapamycin-insensitive companion of mTOR, middle domain
RasGEF_N_2 (PF14663): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_V (PF14668): Rapamycin-insensitive companion of mTOR, domain 5
RICTOR_phospho (PF14665): Rapamycin-insensitive companion of mTOR, phosphorylation-site
Rpa1
tumor suppressor150.35244.656Rep-A_N (PF04057): Replication factor-A protein 1, N-terminal domain
tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900): Replication protein A OB domain
Rep_fac-A_C (PF08646): Replication factor-A C terminal domain
Rpa3
interactor130.34832.233Rep_fac-A_3 (PF08661): Replication factor A protein 3
Rpl23
interactor30.6671.000Ribosomal_L14 (PF00238): Ribosomal protein L14p/L23e
Rpusd2
interactor60.6674.333PseudoU_synth_2 (PF00849): RNA pseudouridylate synthase
Sass6
interactor21.0000SAS-6_N (PF16531): Centriolar protein SAS N-terminal
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
CALCOCO1 (PF07888): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF2951 (PF11166): Protein of unknown function (DUF2951)
Sbds
oncogene21.0000SBDS (PF01172): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377): SBDS protein C-terminal domain
Sept2
oncogene21.0000Septin (PF00735): Septin
FYVE_2 (PF02318): FYVE-type zinc finger
Sept8
interactor21.0000Septin (PF00735): Septin
IMD (PF08397): IRSp53/MIM homology domain
DUF3987 (PF13148): Protein of unknown function (DUF3987)
Serpinh1
interactor21.0000Serpin (PF00079): Serpin (serine protease inhibitor)
Sh3glb1
tumor suppressor70.8001.500BAR (PF03114): BAR domain
SH3_9 (PF14604): Variant SH3 domain
SH3_1 (PF00018): SH3 domain
Sh3glb2
interactor70.5717.000BAR (PF03114): BAR domain
SH3_9 (PF14604): Variant SH3 domain
Srm
interactor100Spermine_synth (PF01564): Spermine/spermidine synthase
Ssfa2
interactor100KRAP_IP3R_bind (PF14722): Ki-ras-induced actin-interacting protein-IP3R-interacting domain
SSFA2_C (PF14723): Sperm-specific antigen 2 C-terminus
Stil
oncogene21.0000STIL_N (PF15253): SCL-interrupting locus protein N-terminus
Tab1
interactor40.5002.667PP2C (PF00481): Protein phosphatase 2C
Tars
interactor30.6670.667TGS (PF02824): TGS domain
tRNA_SAD (PF07973): Threonyl and Alanyl tRNA synthetase second additional domain
tRNA-synt_2b (PF00587): tRNA synthetase class II core domain (G, H, P, S and T)
HGTP_anticodon (PF03129): Anticodon binding domain
Tat
tumor suppressor200TAT_ubiq (PF07706): Aminotransferase ubiquitination site
Aminotran_1_2 (PF00155): Aminotransferase class I and II
Tbcb
interactor100Ubiquitin_2 (PF14560): Ubiquitin-like domain
CAP_GLY (PF01302): CAP-Gly domain
Thg1l
interactor110.55611.089Thg1 (PF04446): tRNAHis guanylyltransferase
Thg1C (PF14413): Thg1 C terminal domain
Tp53rk
oncogene50.9000.400Kdo (PF06293): Lipopolysaccharide kinase (Kdo/WaaP) family
Tpd52l2
interactor110.53314.089TPD52 (PF04201): Tumour protein D52 family
Trappc4
interactor200Sybindin (PF04099): Sybindin-like family
Trmt10a
oncogene41.0000RseA_C (PF03873): Anti sigma-E protein RseA, C-terminal domain
Presenilin (PF01080): Presenilin
tRNA_m1G_MT (PF01746): tRNA (Guanine-1)-methyltransferase
PcfK (PF14058): PcfK-like protein
Tuba8
interactor100.38918.500Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Ubqln2
interactor50.8330.333SUZ (PF12752): SUZ domain
ubiquitin (PF00240): Ubiquitin family
DUF2057 (PF09829): Uncharacterized protein conserved in bacteria (DUF2057)
Herpes_capsid (PF06112): Gammaherpesvirus capsid protein
Fur_reg_FbpB (PF13040): Fur-regulated basic protein B
Clathrin-link (PF09268): Clathrin, heavy-chain linker
XPC-binding (PF09280): XPC-binding domain
Herpes_pp85 (PF04637): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
Collagen (PF01391): Collagen triple helix repeat (20 copies)
DUF3682 (PF12446): Protein of unknown function (DUF3682)
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
UBA (PF00627): UBA/TS-N domain
Ubxn1
interactor41.0000UBA (PF00627): UBA/TS-N domain
eIF3_subunit (PF08597): Translation initiation factor eIF3 subunit
Selenoprotein_S (PF06936): Selenoprotein S (SelS)
UBX (PF00789): UBX domain
Wnk1
interactor31.0000TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Pkinase (PF00069): Protein kinase domain
OSR1_C (PF12202): Oxidative-stress-responsive kinase 1 C terminal
SynMuv_product (PF06047): Ras-induced vulval development antagonist
TraV (PF09676): Type IV conjugative transfer system lipoprotein (TraV)
Ykt6
interactor100Longin (PF13774): Regulated-SNARE-like domain
Synaptobrevin (PF00957): Synaptobrevin

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