Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aars2 (from a repository: Wed Apr 11 17:33:34 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins4 (19.05 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)35 (16.67 %)
The number (and %) of affected PPIs20 (57.14 %)
PPI diameter2
PPI radius1
The average degree of PPI2.667
Assortativity coefficient-0.5793
The network average Clustering coefficient0.391
The number (and %) of a zero Clustering coefficients10 (47.62 %)
The number (and %) of a zero Betweenness Centrality15 (71.43 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aars2
user protein, oncogene200.042357.000tRNA-synt_2c (PF01411): tRNA synthetases class II (A)
tRNA_SAD (PF07973): Threonyl and Alanyl tRNA synthetase second additional domain
Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain
App
interactor50.5003.000APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Bmi1
oncogene31.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Cd70
interactor100TNF (PF00229): TNF(Tumour Necrosis Factor) family
Epha1
oncogene, tumor suppressor100Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Fbxw11
interactor40.6671.000Beta-TrCP_D (PF12125): D domain of beta-TrCP
F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_N (PF08801): Nup133 N terminal like
Fgl1
interactor100DUF1818 (PF08848): Domain of unknown function (DUF1818)
Fibrinogen_C (PF00147): Fibrinogen beta and gamma chains, C-terminal globular domain
Foxb1
interactor100Forkhead (PF00250): Forkhead domain
Foxl1
oncogene100Forkhead (PF00250): Forkhead domain
Mrpl4
interactor21.0000Ribosomal_L4 (PF00573): Ribosomal protein L4/L1 family
Ndufs7
interactor200Oxidored_q6 (PF01058): NADH ubiquinone oxidoreductase, 20 Kd subunit
Ntrk1
oncogene40.6671.000LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Oxld1
interactor100Oxidored-like (PF09791): Oxidoreductase-like protein, N-terminal
TAL_effector (PF03377): TAL effector repeat
Rap1b
oncogene21.0000Ras (PF00071): Ras family
Rars2
interactor21.0000tRNA-synt_1d (PF00750): tRNA synthetases class I (R)
DALR_1 (PF05746): DALR anticodon binding domain
Rbm3
interactor100RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rnf2
interactor40.6671.000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Suclg1
interactor100CoA_binding (PF02629): CoA binding domain
CoA_binding_2 (PF13380): CoA binding domain
Ligase_CoA (PF00549): CoA-ligase
Trmt1
interactor100TRM (PF02005): N2,N2-dimethylguanosine tRNA methyltransferase
zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Ywhaq
interactor30.6671.00014-3-3 (PF00244): 14-3-3 protein
Znrf1
interactor31.0000zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding
RNF220 (PF15926): E3 ubiquitin-protein ligase RNF220
zf-RING_2 (PF13639): Ring finger domain

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