Find Protein-Protein Interactions (PPI) Network

Choose & Enter
Choose animal: Visualization driver:
Protein/NCBI_ID(s):
Refseq_ID(s):
KEGG_KO(s):


Level of PPIs:
or Upload text file:
Update repository

Visible interactions: Visible interactors: Size of node:

Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aars (from a repository: Sun Apr 15 00:01:54 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins8 (15.69 %)
The number (and %) of the tumor suppressors3 (5.88 %)
Total number of binary PPIs (saturation %)262 (20.55 %)
The number (and %) of affected PPIs50 (19.08 %)
PPI diameter2
PPI radius1
The average degree of PPI9.569
Assortativity coefficient-0.2220
The network average Clustering coefficient0.475
The number (and %) of a zero Clustering coefficients2 (3.92 %)
The number (and %) of a zero Betweenness Centrality3 (5.88 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aars
user protein500.1581304.117tRNA-synt_2c (PF01411): tRNA synthetases class II (A)
tRNA_SAD (PF07973): Threonyl and Alanyl tRNA synthetase second additional domain
Syntaxin-6_N (PF09177): Syntaxin 6, N-terminal
DHHA1 (PF02272): DHHA1 domain
Abce1
interactor100.44413.183RLI (PF04068): Possible Fer4-like domain in RNase L inhibitor, RLI
Fer4 (PF00037): 4Fe-4S binding domain
Fer4_7 (PF12838): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
Acta2
interactor100Actin (PF00022): Actin
Ankmy2
interactor40.6671.500Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_3 (PF13606): Ankyrin repeat
zf-C6H2 (PF15801): zf-MYND-like zinc finger, mRNA-binding
zf-MYND (PF01753): MYND finger
Arpc1b
interactor100.48915.419ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40 (PF00400): WD domain, G-beta repeat
eIF2A (PF08662): Eukaryotic translation initiation factor eIF2A
Asns
oncogene120.54513.788GATase_7 (PF13537): Glutamine amidotransferase domain
Asn_synthase (PF00733): Asparagine synthase
Cacybp
interactor110.46714.869Siah-Interact_N (PF09032): Siah interacting protein, N terminal
CS (PF04969): CS domain
SGS (PF05002): SGS domain
Calu
interactor130.33339.419EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_8 (PF13833): EF-hand domain pair
Ciapin1
interactor100.5837.301Methyltransf_11 (PF08241): Methyltransferase domain
Methyltransf_29 (PF03141): Putative S-adenosyl-L-methionine-dependent methyltransferase
CIAPIN1 (PF05093): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Dars
interactor100.6675.067tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
tRNA-synt_2 (PF00152): tRNA synthetases class II (D, K and N)
Dpp8
interactor30.6670.400DPPIV_N (PF00930): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326): Prolyl oligopeptidase family
Dpp9
interactor70.5247.000DPPIV_N (PF00930): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326): Prolyl oligopeptidase family
Eef2k
interactor50.4003.367Alpha_kinase (PF02816): Alpha-kinase family
Sel1 (PF08238): Sel1 repeat
DUF1771 (PF08590): Domain of unknown function (DUF1771)
Eif4a3
interactor100.38911.474DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Farsb
interactor80.4646.807B5 (PF03484): tRNA synthetase B5 domain
B3_4 (PF03483): B3/4 domain
Fn1
oncogene140.37427.119fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Gars
interactor120.51516.402WHEP-TRS (PF00458): WHEP-TRS domain
tRNA-synt_2b (PF00587): tRNA synthetase class II core domain (G, H, P, S and T)
HGTP_anticodon (PF03129): Anticodon binding domain
Hsf1
heat shock100.41715.267HSF_DNA-bind (PF00447): HSF-type DNA-binding
DUF247 (PF03140): Plant protein of unknown function
Vert_HS_TF (PF06546): Vertebrate heat shock transcription factor
Hsp90aa1
oncogene120.43616.898HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Hsp90ab1
oncogene130.45518.031HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Iars
interactor140.59314.375tRNA-synt_1 (PF00133): tRNA synthetases class I (I, L, M and V)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
Ipo11
interactor110.45517.305IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
HEAT (PF02985): HEAT repeat
DUF1539 (PF07560): Domain of Unknown Function (DUF1539)
Isg15
tumor suppressor70.4766.133ubiquitin (PF00240): Ubiquitin family
Itga4
interactor160.41029.851FG-GAP (PF01839): FG-GAP repeat
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2 (PF08441): Integrin alpha
DUF1945 (PF09178): Domain of unknown function (DUF1945)
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
LOC103732255
interactor60.4672.621Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain
Lars
interactor150.45730.524tRNA-synt_1 (PF00133): tRNA synthetases class I (I, L, M and V)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
Mettl1
interactor70.6194.967Methyltransf_4 (PF02390): Putative methyltransferase
Mov10
interactor50.6002.317AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
Msh2
oncogene, tumor suppressor60.5002.417MutS_I (PF01624): MutS domain I
MutS_II (PF05188): MutS domain II
MutS_III (PF05192): MutS domain III
AAA_27 (PF13514): AAA domain
MutS_V (PF00488): MutS domain V
Nars
interactor70.6672.665tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
tRNA-synt_2 (PF00152): tRNA synthetases class II (D, K and N)
Nif3l1
interactor80.5715.633NIF3 (PF01784): NIF3 (NGG1p interacting factor 3)
Nmd3
interactor90.5288.582NMD3 (PF04981): NMD3 family
HGTP_anticodon2 (PF12745): Anticodon binding domain of tRNAs
Nsun2
interactor70.4296.256Methyltr_RsmB-F (PF01189): 16S rRNA methyltransferase RsmB/F
Ntrk1
oncogene290.193221.903LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nxf1
interactor110.28920.867Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Pdia3
interactor50.7001.417Thioredoxin (PF00085): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
Ppp2r5e
interactor41.0000B56 (PF01603): Protein phosphatase 2A regulatory B subunit (B56 family)
Qars
interactor110.58212.522tRNA_synt_1c_R1 (PF04558): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
tRNA-synt_1c (PF00749): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950): tRNA synthetases class I (E and Q), anti-codon binding domain
Sae1
interactor70.5247.467ThiF (PF00899): ThiF family
Sbds
oncogene100SBDS (PF01172): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377): SBDS protein C-terminal domain
Sirt7
interactor100.24422.452DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Srp9
interactor80.35713.233SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
Stat1
tumor suppressor80.4766.238STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain
STAT1_TAZ2bind (PF12162): STAT1 TAZ2 binding domain
Stat5b
oncogene80.4768.487STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain
Tarsl2
interactor40.5000.968TGS (PF02824): TGS domain
tRNA_SAD (PF07973): Threonyl and Alanyl tRNA synthetase second additional domain
tRNA-synt_2b (PF00587): tRNA synthetase class II core domain (G, H, P, S and T)
HGTP_anticodon (PF03129): Anticodon binding domain
Tom1l1
interactor60.6673.067VHS (PF00790): VHS domain
GAT (PF03127): GAT domain
Tpd52
oncogene70.6002.800TPD52 (PF04201): Tumour protein D52 family
Tpd52l2
interactor110.48916.300TPD52 (PF04201): Tumour protein D52 family
Uba1
interactor140.50022.901ThiF (PF00899): ThiF family
UBA_e1_thiolCys (PF10585): Ubiquitin-activating enzyme active site
E1_UFD (PF09358): Ubiquitin fold domain
Vcam1
interactor140.35227.102I-set (PF07679): Immunoglobulin I-set domain
C2-set (PF05790): Immunoglobulin C2-set domain
ig (PF00047): Immunoglobulin domain
Ig_2 (PF13895): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
Wars
interactor50.5003.202WHEP-TRS (PF00458): WHEP-TRS domain
tRNA-synt_1b (PF00579): tRNA synthetases class I (W and Y)

B a c k    t o    T o p ⇑