Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aak1 (from a repository: Tue Apr 17 17:19:54 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins4 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)23 (82.14 %)
The number (and %) of affected PPIs7 (30.43 %)
PPI diameter2
PPI radius1
The average degree of PPI4.500
Assortativity coefficient-0.3457
The network average Clustering coefficient0.836
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality3 (37.50 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aak1
user protein70.52411.500Pkinase (PF00069): Protein kinase domain
ATG16 (PF08614): Autophagy protein 16 (ATG16)
DUF3123 (PF11321): Protein of unknown function (DUF3123)
Ap2a1
interactor50.9000.500Adaptin_N (PF01602): Adaptin N terminal region
HEAT_2 (PF13646): HEAT repeats
Alpha_adaptinC2 (PF02883): Adaptin C-terminal domain
Alpha_adaptin_C (PF02296): Alpha adaptin AP2, C-terminal domain
Ap2m1
interactor51.0000Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain
Adap_comp_sub (PF00928): Adaptor complexes medium subunit family
App
interactor31.0000APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Cltc
oncogene60.9000.500Clathrin_propel (PF01394): Clathrin propeller repeat
Clathrin-link (PF09268): Clathrin, heavy-chain linker
Clathrin_H_link (PF13838): Clathrin-H-link
Clathrin (PF00637): Region in Clathrin and VPS
Gak
oncogene60.6674.500Pkinase (PF00069): Protein kinase domain
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
DnaJ (PF00226): DnaJ domain
Hspa5
heat shock, oncogene31.0000HSP70 (PF00012): Hsp70 protein
Ntrk1
oncogene60.7003.000LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

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