Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Alk
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Visible interactions:

Visible interactors:

Size of node:

Visualization interactions

Cytoscape Web taxid = 1026970 for: protein(s) Alk (from a repository: Thu Jun 21 05:03:31 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	61
The number (and %) of the onco-proteins	22 (36.07 %)
The number (and %) of the tumor suppressors	10 (16.39 %)
Total number of binary PPIs (saturation %)	214 (11.69 %)
The number (and %) of affected PPIs	60 (28.04 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	6.131
Assortativity coefficient	-0.4619
The network average Clustering coefficient	0.545
The number (and %) of a zero Clustering coefficients	12 (19.67 %)
The number (and %) of a zero Betweenness Centrality	24 (39.34 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Alk

XP_008844703.1

Domain structure obtained by HMM

Protein ID: XP_008844703.1 - ALK tyrosine kinase receptor
KEEG Ortholog ID: K05119

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MAM	PF00629	160	0.0000000000017	33.700	269	428	269	429	MAM domain, meprin/A5/mu
Ldl_recept_a	PF00057	37	0.0000054	12.900	442	474	440	474	Low-density lipoprotein receptor domain class A
MAM	PF00629	160	9.6e-24	70.200	483	641	483	642	MAM domain, meprin/A5/mu
Gly_rich	PF12810	243	2e-20	59.800	736	966	731	997	Glycine rich protein
FXa_inhibition	PF14670	36	0.0000026	14.000	992	1026	990	1026	Coagulation Factor Xa inhibitory site
Pkinase_Tyr	PF07714	260	8.4e-93	296.500	1122	1387	1121	1388	Protein tyrosine kinase

user protein, oncogene

0.072

2735.633

MAM (PF00629): MAM domain, meprin/A5/mu
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Actb

XP_008849594.1

Domain structure obtained by HMM

Protein ID: XP_008849594.1 - actin, cytoplasmic 1
KEEG Ortholog ID: K05692

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Actin	PF00022	407	2.3e-155	503.200	3	375	2	375	Actin

oncogene

0.619

6.000

Actin (PF00022): Actin

Actn4

XP_008852142.1

Domain structure obtained by HMM

Protein ID: XP_008852142.1 - alpha-actinin-4 isoform X1
KEEG Ortholog ID: K05699

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CH	PF00307	109	7.3e-29	86.500	51	154	50	155	Calponin homology (CH) domain
CH	PF00307	109	1.5e-30	91.900	164	269	163	270	Calponin homology (CH) domain
Uds1	PF15456	130	0.035	0.500	225	307	214	312	Up-regulated During Septation
Spectrin	PF00435	105	1.5e-19	56.700	293	402	293	403	Spectrin repeat
Spectrin	PF00435	105	4.8e-27	80.800	413	517	413	518	Spectrin repeat
Spectrin	PF00435	105	2.1e-21	62.700	529	639	528	639	Spectrin repeat
Spectrin	PF00435	105	2e-17	49.900	649	751	649	752	Spectrin repeat
EF-hand_7	PF13499	71	0.0000000028	23.700	770	835	767	836	EF-hand domain pair
EFhand_Ca_insen	PF08726	69	7.6e-31	92.400	841	907	841	907	Ca2+ insensitive EF hand

interactor

1.000

CH (PF00307): Calponin homology (CH) domain
Uds1 (PF15456): Up-regulated During Septation
Spectrin (PF00435): Spectrin repeat
EF-hand_7 (PF13499): EF-hand domain pair
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand

Bcar1

XP_017651061.1

Domain structure obtained by HMM

Protein ID: XP_017651061.1 - breast cancer anti-estrogen resistance protein 1
KEEG Ortholog ID: K05726

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_1	PF00018	48	7.4e-18	50.300	9	56	9	57	SH3 domain
Extensin_2	PF04554	58	0.043	0.300	96	145	92	158	Extensin-like region
Serine_rich	PF08824	157	8.6e-48	148.500	458	611	458	612	Serine rich protein interaction domain
DUF3513	PF12026	195	5.4e-80	254.100	659	868	658	868	Domain of unknown function (DUF3513)

oncogene

0.867

1.000

SH3_1 (PF00018): SH3 domain
Extensin_2 (PF04554): Extensin-like region
Serine_rich (PF08824): Serine rich protein interaction domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)

Bicd2

XP_008851080.1

Domain structure obtained by HMM

Protein ID: XP_008851080.1 - protein bicaudal D homolog 2 isoform X1
KEEG Ortholog ID: K18739

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HALZ	PF02183	43	0.000076	9.200	57	79	49	83	Homeobox associated leucine zipper
BicD	PF09730	719	0	1211.900	83	797	83	797	Microtubule-associated protein Bicaudal-D
DUF4666	PF15697	111	0.000066	9.900	757	832	748	837	Domain of unknown function (DUF4666)

interactor

HALZ (PF02183): Homeobox associated leucine zipper
BicD (PF09730): Microtubule-associated protein Bicaudal-D
DUF4666 (PF15697): Domain of unknown function (DUF4666)

Cdk13

XP_017654470.1

Domain structure obtained by HMM

Protein ID: XP_017654470.1 - cyclin-dependent kinase 13 isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
K_channel_TID	PF07941	74	0.048	0.500	162	189	158	196	Potassium channel Kv1.4 tandem inactivation domain
Macoilin	PF09726	671	0.014	0.000	176	303	149	359	Transmembrane protein
THRAP3_BCLAF1	PF15440	664	0.0000006	14.800	395	589	392	683	THRAP3/BCLAF1 family
CPSF100_C	PF13299	169	0.024	1.000	544	610	531	625	Cleavage and polyadenylation factor 2 C-terminal
Pkinase	PF00069	264	7.5e-78	247.600	708	999	706	999	Protein kinase domain
PRIMA1	PF16101	121	0.027	0.800	995	1033	985	1037	Proline-rich membrane anchor 1

interactor

0.833

0.667

K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
Macoilin (PF09726): Transmembrane protein
THRAP3_BCLAF1 (PF15440): THRAP3/BCLAF1 family
CPSF100_C (PF13299): Cleavage and polyadenylation factor 2 C-terminal
Pkinase (PF00069): Protein kinase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

Cdk9

XP_008823373.1

Domain structure obtained by HMM

Protein ID: XP_008823373.1 - cyclin-dependent kinase 9
KEEG Ortholog ID: K02211

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	2.8e-74	235.900	19	315	19	315	Protein kinase domain

interactor

0.700

2.167

Pkinase (PF00069): Protein kinase domain

Cenpf

XP_008823082.1

Domain structure obtained by HMM

Protein ID: XP_008823082.1 - centromere protein F isoform X1
KEEG Ortholog ID: K11499

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CENP-F_N	PF10481	307	1.3e-147	477.400	1	306	1	306	Cenp-F N-terminal domain
Fez1	PF06818	198	0.000038	10.300	276	432	274	441	Fez1
TPR_MLP1_2	PF07926	129	0.0000036	13.300	385	496	383	497	TPR/MLP1/MLP2-like protein
DivIVA	PF05103	131	0.0015	4.900	478	567	474	574	DivIVA protein
bZIP_1	PF00170	64	0.0000054	12.800	574	615	567	616	bZIP transcription factor
DUF1664	PF07889	124	0.000015	11.200	626	686	621	696	Protein of unknown function (DUF1664)
Tup_N	PF08581	77	0.00021	7.900	714	763	707	766	Tup N-terminal
TPR_MLP1_2	PF07926	129	0.0000063	12.500	857	976	851	979	TPR/MLP1/MLP2-like protein
Sec20	PF03908	92	0.000069	9.100	945	1006	939	1014	Sec20
TPR_MLP1_2	PF07926	129	0.00022	7.600	976	1099	974	1102	TPR/MLP1/MLP2-like protein
DUF3450	PF11932	241	0.00012	7.600	1118	1184	1101	1191	Protein of unknown function (DUF3450)
TMF_DNA_bd	PF12329	74	0.00038	6.800	1205	1232	1197	1238	TATA element modulatory factor 1 DNA binding
DPM3	PF08285	91	0.0055	3.200	1216	1243	1208	1244	Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Spc7	PF08317	310	0.0032	2.400	1270	1347	1253	1356	Spc7 kinetochore protein
GIT_CC	PF16559	66	0.00013	8.300	1390	1444	1380	1447	GIT coiled-coil Rho guanine nucleotide exchange factor
DUF972	PF06156	102	0.0026	4.700	1415	1458	1399	1472	Protein of unknown function (DUF972)
Bcr-Abl_Oligo	PF09036	73	0.00043	6.600	1531	1570	1524	1595	Bcr-Abl oncoprotein oligomerisation domain
E2F_CC-MB	PF16421	92	0.004	3.900	1545	1581	1537	1592	E2F transcription factor CC-MB domain
CENP-Q	PF13094	155	0.011	2.100	1574	1629	1520	1699	CENP-Q, a CENPA-CAD centromere complex subunit
HIP1_clath_bdg	PF16515	99	0.011	2.700	1599	1645	1593	1661	Clathrin-binding domain of Huntingtin-interacting protein 1
Cep57_MT_bd	PF06657	77	0.012	2.400	1622	1671	1599	1674	Centrosome microtubule-binding domain of Cep57
CLZ	PF16526	71	0.0041	3.800	1752	1806	1748	1812	C-terminal leucine zipper domain of cyclic nucleotide-gated channels
bZIP_1	PF00170	64	0.00092	5.600	1815	1843	1813	1851	bZIP transcription factor
CENP-F_leu_zip	PF10473	140	0.000000000074	28.400	1881	2023	1881	2023	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
APG6	PF04111	312	0.00000094	14.500	1950	2085	1948	2091	Autophagy protein Apg6
DUF5082	PF16888	123	0.000031	10.600	2023	2117	2014	2119	Domain of unknown function (DUF5082)
CENP-F_leu_zip	PF10473	140	5.1e-51	158.600	2119	2258	2119	2258	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP	PF11559	152	0.0017	4.700	2260	2337	2249	2339	Afadin- and alpha -actinin-Binding
CENP-F_leu_zip	PF10473	140	8.6e-47	144.900	2302	2440	2301	2440	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TPR_MLP1_2	PF07926	129	0.0000058	12.600	2445	2574	2442	2574	TPR/MLP1/MLP2-like protein
Spc7	PF08317	310	0.00000091	14.100	2568	2730	2564	2748	Spc7 kinetochore protein
TMF_TATA_bd	PF12325	115	0.000067	9.400	2676	2752	2670	2761	TATA element modulatory factor 1 TATA binding
HALZ	PF02183	43	0.0011	5.500	2736	2763	2734	2766	Homeobox associated leucine zipper
CENP-F_C_Rb_bdg	PF10490	47	2.8e-29	86.700	2842	2886	2840	2886	Rb-binding domain of kinetochore protein Cenp-F/LEK1

oncogene

1.000

CENP-F_N (PF10481): Cenp-F N-terminal domain
Fez1 (PF06818): Fez1
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
DivIVA (PF05103): DivIVA protein
bZIP_1 (PF00170): bZIP transcription factor
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Tup_N (PF08581): Tup N-terminal
Sec20 (PF03908): Sec20
DUF3450 (PF11932): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
DPM3 (PF08285): Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Spc7 (PF08317): Spc7 kinetochore protein
GIT_CC (PF16559): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF972 (PF06156): Protein of unknown function (DUF972)
Bcr-Abl_Oligo (PF09036): Bcr-Abl oncoprotein oligomerisation domain
E2F_CC-MB (PF16421): E2F transcription factor CC-MB domain
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Cep57_MT_bd (PF06657): Centrosome microtubule-binding domain of Cep57
CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
APG6 (PF04111): Autophagy protein Apg6
DUF5082 (PF16888): Domain of unknown function (DUF5082)
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
HALZ (PF02183): Homeobox associated leucine zipper
CENP-F_C_Rb_bdg (PF10490): Rb-binding domain of kinetochore protein Cenp-F/LEK1

Coro1c

XP_008847173.1

Domain structure obtained by HMM

Protein ID: XP_008847173.1 - coronin-1C
KEEG Ortholog ID: K13886

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF1899	PF08953	66	5e-36	108.800	3	68	3	68	Domain of unknown function (DUF1899)
WD40	PF00400	38	0.0000000019	24.500	76	108	69	109	WD domain, G-beta repeat
WD40	PF00400	38	0.0000014	15.400	122	159	120	159	WD domain, G-beta repeat
ANAPC4_WD40	PF12894	92	0.000001	15.300	173	213	168	226	Anaphase-promoting complex subunit 4 WD40 domain
WD40_4	PF16300	44	5.3e-26	76.600	343	385	343	385	Type of WD40 repeat

oncogene

1.000

DUF1899 (PF08953): Domain of unknown function (DUF1899)
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat

Eif4b

XP_008836569.1

Domain structure obtained by HMM

Protein ID: XP_008836569.1 - eukaryotic translation initiation factor 4B isoform X1
KEEG Ortholog ID: K03258

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	7.8e-17	47.200	99	167	98	167	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774	PF12609	75	0.0067	3.800	329	378	321	386	Wound-induced protein

interactor

1.000

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609): Wound-induced protein

Epha1

XP_008826846.1

Domain structure obtained by HMM

Protein ID: XP_008826846.1 - ephrin type-A receptor 1
KEEG Ortholog ID: K05102

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ephrin_lbd	PF01404	178	8.6e-60	188.000	28	204	28	204	Ephrin receptor ligand binding domain
Ephrin_rec_like	PF07699	48	0.0000000025	23.100	272	309	267	313	Putative ephrin-receptor like
fn3	PF00041	85	1.3e-20	59.900	334	427	334	431	Fibronectin type III domain
fn3	PF00041	85	0.00000000046	26.100	457	528	450	528	Fibronectin type III domain
EphA2_TM	PF14575	77	2.2e-19	56.400	548	620	548	620	Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr	PF07714	260	6.6e-98	313.200	624	879	623	879	Protein tyrosine kinase
SAM_1	PF00536	64	1e-26	79.500	913	974	910	974	SAM domain (Sterile alpha motif)

oncogene, tumor suppressor

0.667

0.500

Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)

Ephb2

XP_008846790.1

Domain structure obtained by HMM

Protein ID: XP_008846790.1 - ephrin type-B receptor 2 isoform X1
KEEG Ortholog ID: K05111

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ephrin_lbd	PF01404	178	2e-76	242.100	1	174	1	174	Ephrin receptor ligand binding domain
EGF_2	PF07974	32	0.000023	11.000	216	238	211	246	EGF-like domain
cEGF	PF12662	24	0.000044	9.700	230	247	230	247	Complement Clr-like EGF-like
Ephrin_rec_like	PF07699	48	0.000000000035	29.100	245	279	238	282	Putative ephrin-receptor like
EGF_2	PF07974	32	0.0073	3.000	276	287	255	290	EGF-like domain
fn3	PF00041	85	2.8e-21	62.000	303	398	303	398	Fibronectin type III domain
fn3	PF00041	85	3.6e-20	58.400	415	497	411	497	Fibronectin type III domain
EphA2_TM	PF14575	77	3e-27	81.600	521	595	521	596	Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr	PF07714	260	2.3e-102	327.800	600	858	599	858	Protein tyrosine kinase
SAM_1	PF00536	64	1.4e-24	72.600	890	952	889	953	SAM domain (Sterile alpha motif)

tumor suppressor

1.000

Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)

Errfi1

XP_008820670.1

Domain structure obtained by HMM

Protein ID: XP_008820670.1 - ERBB receptor feedback inhibitor 1 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
GTPase_binding	PF09027	68	0.000000097	18.300	4	41	4	54	GTPase binding
Inhibitor_Mig-6	PF11555	60	0.0042	3.500	279	291	252	308	EGFR receptor inhibitor Mig-6
Inhibitor_Mig-6	PF11555	60	5.9e-19	54.300	313	367	313	369	EGFR receptor inhibitor Mig-6

oncogene, tumor suppressor

0.800

0.917

GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6

Flii

XP_008820183.1

Domain structure obtained by HMM

Protein ID: XP_008820183.1 - protein flightless-1 homolog isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRR_4	PF12799	43	0.015	2.200	13	42	10	53	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	0.000000000025	29.500	34	91	33	91	Leucine rich repeat
LRR_8	PF13855	61	0.0000000012	24.200	95	139	92	139	Leucine rich repeat
LRR_8	PF13855	61	0.000000000000056	38.000	131	186	127	186	Leucine rich repeat
LRR_4	PF12799	43	0.00017	8.300	175	210	174	224	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	0.00000000000027	35.800	200	258	198	258	Leucine rich repeat
LRR_4	PF12799	43	0.000000000029	29.900	271	310	269	311	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	0.00000023	16.800	315	352	307	366	Leucine rich repeat
LRR_1	PF00560	23	0.016	2.600	341	361	341	362	Leucine Rich Repeat
SRP-alpha_N	PF04086	292	0.00000042	16.200	387	458	366	474	Signal recognition particle, alpha subunit, N-terminal
Gelsolin	PF00626	76	1.5e-19	56.000	478	560	477	560	Gelsolin repeat
Gelsolin	PF00626	76	1.2e-17	49.900	598	672	597	672	Gelsolin repeat
Gelsolin	PF00626	76	0.00000000013	27.400	730	800	725	801	Gelsolin repeat
Gelsolin	PF00626	76	0.000002	14.000	894	1000	889	1000	Gelsolin repeat
Gelsolin	PF00626	76	0.00000007	18.600	1044	1112	1038	1113	Gelsolin repeat
Gelsolin	PF00626	76	0.00000000000018	36.600	1149	1223	1146	1224	Gelsolin repeat

oncogene

0.667

0.900

LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
Gelsolin (PF00626): Gelsolin repeat

Gak

XP_008840005.1

Domain structure obtained by HMM

Protein ID: XP_008840005.1 - cyclin-G-associated kinase isoform X1
KEEG Ortholog ID: K08855

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	9.5e-52	162.000	43	311	40	313	Protein kinase domain
Y_phosphatase	PF00102	235	0.000021	10.300	473	533	434	563	Protein-tyrosine phosphatase
DSPc	PF00782	133	0.000019	10.700	498	547	480	558	Dual specificity phosphatase, catalytic domain
PTEN_C2	PF10409	135	2.9e-33	100.700	571	707	570	709	C2 domain of PTEN tumour-suppressor protein
DnaJ	PF00226	63	0.000000000047	29.000	1245	1297	1239	1300	DnaJ domain

oncogene

0.667

1.000

Pkinase (PF00069): Protein kinase domain
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
DnaJ (PF00226): DnaJ domain

Grb2

XP_008829635.1

Domain structure obtained by HMM

Protein ID: XP_008829635.1 - growth factor receptor-bound protein 2
KEEG Ortholog ID: K04364

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_1	PF00018	48	1.5e-20	58.900	4	50	4	50	SH3 domain
SH2	PF00017	77	6.1e-29	86.300	60	135	60	135	SH2 domain
DUF5093	PF17011	131	0.0000023	14.200	98	155	90	165	Domain of unknown function (DUF5093)
SH3_1	PF00018	48	1.3e-20	59.100	162	206	162	207	SH3 domain

oncogene

0.264

133.533

SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)

Hsp90aa1

XP_008823821.1

Domain structure obtained by HMM

Protein ID: XP_008823821.1 - heat shock protein HSP 90-alpha
KEEG Ortholog ID: K04079

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HATPase_c	PF02518	111	7.3e-18	51.500	40	193	40	194	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90	PF00183	518	2.9e-246	804.200	196	716	196	723	Hsp90 protein

oncogene

0.268

89.483

HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein

Hspd1

XP_008846515.2

Domain structure obtained by HMM

Protein ID: XP_008846515.2 - 60 kDa heat shock protein, mitochondrial
KEEG Ortholog ID: K04077

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Cpn60_TCP1	PF00118	491	4.6e-90	288.600	47	548	47	550	TCP-1/cpn60 chaperonin family

oncogene, tumor suppressor

0.700

2.000

Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family

Ikbkg

XP_017652770.1

Domain structure obtained by HMM

Protein ID: XP_017652770.1 - NF-kappa-B essential modulator isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NEMO	PF11577	68	6.8e-32	95.700	44	111	44	111	NF-kappa-B essential modulator NEMO
APC_u15	PF16636	81	0.0000085	12.500	107	146	105	161	Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5	PF09787	306	0.0000014	14.100	152	285	139	289	Golgin subfamily A member 5
CC2-LZ	PF16516	104	2.6e-33	100.800	248	343	239	343	Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1	PF14945	119	0.00002	11.400	302	360	300	386	Normal lung function maintenance, Low in Lung Cancer 1 protein

interactor

0.389

17.900

NEMO (PF11577): NF-kappa-B essential modulator NEMO
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5 (PF09787): Golgin subfamily A member 5
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1 (PF14945): Normal lung function maintenance, Low in Lung Cancer 1 protein

Irf7

XP_008852618.1

Domain structure obtained by HMM

Protein ID: XP_008852618.1 - interferon regulatory factor 7 isoform X2
KEEG Ortholog ID: K09447

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IRF	PF00605	105	5.1e-41	125.500	12	121	11	122	Interferon regulatory factor transcription factor
IRF-3	PF10401	180	4e-50	156.200	243	421	242	422	Interferon-regulatory factor 3

interactor

IRF (PF00605): Interferon regulatory factor transcription factor
IRF-3 (PF10401): Interferon-regulatory factor 3

Irs1

XP_008824062.1

Domain structure obtained by HMM

Protein ID: XP_008824062.1 - insulin receptor substrate 1
KEEG Ortholog ID: K16172

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PH	PF00169	105	0.000000000000073	38.500	22	111	9	114	PH domain
IRS	PF02174	100	2.8e-35	106.600	157	257	156	258	PTB domain (IRS-1 type)

interactor

0.714

3.833

PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)

Irs4

XP_008851185.1

Domain structure obtained by HMM

Protein ID: XP_008851185.1 - insulin receptor substrate 4
KEEG Ortholog ID: K17446

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TAT_signal	PF10518	26	0.043	0.200	15	32	15	33	TAT (twin-arginine translocation) pathway signal sequence
PH_11	PF15413	105	0.00000076	15.800	83	196	82	198	Pleckstrin homology domain
IRS	PF02174	100	3.4e-33	99.800	234	334	233	335	PTB domain (IRS-1 type)
CAP_N	PF01213	317	0.000019	10.400	634	654	614	669	Adenylate cyclase associated (CAP) N terminal
CAP_N	PF01213	317	0.0025	3.400	765	788	736	798	Adenylate cyclase associated (CAP) N terminal
Ribosomal_60s	PF00428	88	0.0029	4.500	1214	1256	1189	1261	60s Acidic ribosomal protein

interactor

0.833

0.250

TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
IRS (PF02174): PTB domain (IRS-1 type)
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein

Jak2

XP_008839879.1

Domain structure obtained by HMM

Protein ID: XP_008839879.1 - tyrosine-protein kinase JAK2 isoform X2
KEEG Ortholog ID: K04447

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
FERM_M	PF00373	118	0.00000028	17.200	143	262	140	269	FERM central domain
SH2	PF00017	77	0.000000000063	28.600	401	481	400	481	SH2 domain
Pkinase_Tyr	PF07714	260	2.8e-66	209.500	546	805	545	805	Protein tyrosine kinase
Pkinase_Tyr	PF07714	260	7.9e-90	286.700	849	1120	849	1123	Protein tyrosine kinase

oncogene

0.500

22.533

FERM_M (PF00373): FERM central domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Jak3

XP_008822806.1

Domain structure obtained by HMM

Protein ID: XP_008822806.1 - tyrosine-protein kinase JAK3
KEEG Ortholog ID: K11218

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
APH	PF01636	240	0.022	0.700	99	244	67	263	Phosphotransferase enzyme family
SH2	PF00017	77	0.000002	14.100	377	454	376	456	SH2 domain
Pkinase_Tyr	PF07714	260	1.2e-56	177.900	521	777	521	777	Protein tyrosine kinase
Pkinase_Tyr	PF07714	260	2.2e-82	262.300	823	1094	822	1095	Protein tyrosine kinase

oncogene

0.700

1.567

APH (PF01636): Phosphotransferase enzyme family
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Krt18

XP_008836537.1

Domain structure obtained by HMM

Protein ID: XP_008836537.1 - keratin, type I cytoskeletal 18
KEEG Ortholog ID: K07604

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Filament	PF00038	312	3.9e-107	344.500	73	383	72	385	Intermediate filament protein
Spc7	PF08317	310	0.0000076	11.000	333	408	326	418	Spc7 kinetochore protein

interactor

0.381

10.067

Filament (PF00038): Intermediate filament protein
Spc7 (PF08317): Spc7 kinetochore protein

Map2k7

XP_008822354.1

Domain structure obtained by HMM

Protein ID: XP_008822354.1 - dual specificity mitogen-activated protein kinase kinase 7 isoform X1
KEEG Ortholog ID: K04431

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	2.9e-60	189.900	161	420	160	420	Protein kinase domain

interactor

0.600

3.567

Pkinase (PF00069): Protein kinase domain

Map3k1

XP_008838602.1

Domain structure obtained by HMM

Protein ID: XP_008838602.1 - mitogen-activated protein kinase kinase kinase 1
KEEG Ortholog ID: K04416

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Phostensin_N	PF13916	86	0.0000058	12.900	189	219	183	232	PP1-regulatory protein, Phostensin N-terminal
zf-Di19	PF05605	54	0.052	0.200	433	444	427	469	Drought induced 19 protein (Di19), zinc-binding
zf-RING_2	PF13639	44	0.0000000011	24.700	439	489	438	489	Ring finger domain
zf-Di19	PF05605	54	0.00032	7.300	474	500	455	503	Drought induced 19 protein (Di19), zinc-binding
Pkinase	PF00069	264	2.7e-70	222.800	1231	1494	1229	1494	Protein kinase domain

oncogene

0.467

5.567

Phostensin_N (PF13916): PP1-regulatory protein, Phostensin N-terminal
zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639): Ring finger domain
Pkinase (PF00069): Protein kinase domain

Map3k5

XP_008820276.1

Domain structure obtained by HMM

Protein ID: XP_008820276.1 - mitogen-activated protein kinase kinase kinase 5 isoform X2
KEEG Ortholog ID: K04426

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4071	PF13281	368	3.4e-161	522.400	169	549	169	549	Domain of unknown function (DUF4071)
Pkinase	PF00069	264	3.3e-68	216.000	689	941	686	942	Protein kinase domain
FPP	PF05911	874	0.00000042	14.600	1080	1291	1034	1295	Filament-like plant protein, long coiled-coil

oncogene

0.571

6.250

DUF4071 (PF13281): Domain of unknown function (DUF4071)
Pkinase (PF00069): Protein kinase domain
FPP (PF05911): Filament-like plant protein, long coiled-coil

Mapk1

XP_008840426.1

Domain structure obtained by HMM

Protein ID: XP_008840426.1 - mitogen-activated protein kinase 1
KEEG Ortholog ID: K04371

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	4e-73	232.100	13	301	13	301	Protein kinase domain

oncogene

0.357

13.317

Pkinase (PF00069): Protein kinase domain

Mapk8ip3

XP_008854413.1

Domain structure obtained by HMM

Protein ID: XP_008854413.1 - C-Jun-amino-terminal kinase-interacting protein 3 isoform X1
KEEG Ortholog ID: K04436

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Jnk-SapK_ap_N	PF09744	156	7.9e-61	191.000	29	184	29	184	JNK_SAPK-associated protein-1
JIP_LZII	PF16471	71	2.1e-33	100.700	423	493	423	493	JNK-interacting protein leucine zipper II
Med21	PF11221	144	0.000067	9.400	441	516	427	519	Subunit 21 of Mediator complex
ERM	PF00769	243	0.000096	8.400	464	665	437	671	Ezrin/radixin/moesin family
UPF0449	PF15136	101	0.012	2.400	646	688	626	696	Uncharacterised protein family UPF0449

interactor

0.600

2.067

Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
Med21 (PF11221): Subunit 21 of Mediator complex
ERM (PF00769): Ezrin/radixin/moesin family
UPF0449 (PF15136): Uncharacterised protein family UPF0449

Mep1b

XP_008827082.1

Domain structure obtained by HMM

Protein ID: XP_008827082.1 - meprin A subunit beta
KEEG Ortholog ID: K08606

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Astacin	PF01400	191	4.9e-75	237.500	71	257	70	258	Astacin (Peptidase family M12A)
MAM	PF00629	160	1.2e-41	128.500	266	429	266	429	MAM domain, meprin/A5/mu
EGF	PF00008	32	0.00000015	18.000	615	641	615	654	EGF-like domain
LRRC37AB_C	PF14914	147	0.00001	11.700	658	689	651	691	LRRC37A/B like protein 1 C-terminal domain

interactor

Astacin (PF01400): Astacin (Peptidase family M12A)
MAM (PF00629): MAM domain, meprin/A5/mu
EGF (PF00008): EGF-like domain
LRRC37AB_C (PF14914): LRRC37A/B like protein 1 C-terminal domain

Mtif2

XP_008821228.1

Domain structure obtained by HMM

Protein ID: XP_008821228.1 - translation initiation factor IF-2, mitochondrial
KEEG Ortholog ID: K02519

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
GTP_EFTU	PF00009	194	4.4e-36	110.400	184	341	180	345	Elongation factor Tu GTP binding domain
GTP_EFTU_D4	PF14578	86	0.035	0.500	377	419	355	422	Elongation factor Tu domain 4
Dynamin_N	PF00350	168	0.0019	4.400	433	488	368	541	Dynamin family
IF-2	PF11987	105	2e-34	104.200	511	607	502	608	Translation-initiation factor 2
GTP_EFTU_D4	PF14578	86	0.000041	9.800	644	702	629	711	Elongation factor Tu domain 4

interactor

GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4
Dynamin_N (PF00350): Dynamin family
IF-2 (PF11987): Translation-initiation factor 2

Mybpc2

XP_008843370.1

Domain structure obtained by HMM

Protein ID: XP_008843370.1 - myosin-binding protein C, fast-type
KEEG Ortholog ID: K12558

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
I-set	PF07679	90	0.00000000024	26.700	50	137	48	149	Immunoglobulin I-set domain
I-set	PF07679	90	0.0000000000014	33.900	253	328	251	333	Immunoglobulin I-set domain
I-set	PF07679	90	0.00000000000036	35.700	343	418	341	430	Immunoglobulin I-set domain
I-set	PF07679	90	0.000000000000021	39.700	436	506	434	519	Immunoglobulin I-set domain
I-set	PF07679	90	2.4e-19	55.600	547	630	542	630	Immunoglobulin I-set domain
fn3	PF00041	85	7.1e-18	51.100	635	720	635	720	Fibronectin type III domain
fn3	PF00041	85	2.3e-16	46.300	733	816	733	818	Fibronectin type III domain
I-set	PF07679	90	6.2e-16	44.600	847	924	838	924	Immunoglobulin I-set domain
fn3	PF00041	85	4.8e-18	51.600	930	1007	929	1012	Fibronectin type III domain
I-set	PF07679	90	5.2e-24	70.500	1043	1132	1043	1132	Immunoglobulin I-set domain

interactor

I-set (PF07679): Immunoglobulin I-set domain
fn3 (PF00041): Fibronectin type III domain

Myh10

XP_017650498.1

Domain structure obtained by HMM

Protein ID: XP_017650498.1 - myosin-10
KEEG Ortholog ID: K10352

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myosin_N	PF02736	40	1.5e-16	46.300	33	73	33	73	Myosin N-terminal SH3-like domain
Myosin_head	PF00063	677	0	1015.700	87	802	87	802	Myosin head (motor domain)
IQ	PF00612	21	0.000000017	20.300	819	837	818	838	IQ calmodulin-binding motif
Myosin_tail_1	PF01576	1081	4.2e-199	649.900	879	1317	879	1318	Myosin tail
Myosin_tail_1	PF01576	1081	1.6e-278	912.900	1315	1873	1313	1873	Myosin tail

interactor

1.000

Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail

Myh9

XP_008853014.1

Domain structure obtained by HMM

Protein ID: XP_008853014.1 - myosin-9 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myosin_N	PF02736	40	0.0000000000001	37.200	29	69	29	69	Myosin N-terminal SH3-like domain
Myosin_head	PF00063	677	0	1022.200	83	764	83	764	Myosin head (motor domain)
IQ	PF00612	21	0.000000069	18.400	783	799	780	800	IQ calmodulin-binding motif
Myosin_tail_1	PF01576	1081	0	1675.800	841	1921	841	1921	Myosin tail

oncogene, tumor suppressor

0.318

39.000

Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail

Mylk

XP_017656046.1

Domain structure obtained by HMM

Protein ID: XP_017656046.1 - myosin light chain kinase, smooth muscle isoform X1
KEEG Ortholog ID: K00907

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
I-set	PF07679	90	3.5e-23	67.800	33	123	33	123	Immunoglobulin I-set domain
I-set	PF07679	90	1.3e-27	82.000	161	250	161	250	Immunoglobulin I-set domain
23ISL	PF16620	162	3.8e-64	202.000	252	403	251	406	Unstructured linker between I-set domains 2 and 3 on MYLCK
I-set	PF07679	90	2.1e-24	71.800	407	497	407	497	Immunoglobulin I-set domain
I-set	PF07679	90	1.5e-23	69.000	507	593	507	593	Immunoglobulin I-set domain
I-set	PF07679	90	2.2e-26	78.100	617	705	616	705	Immunoglobulin I-set domain
I-set	PF07679	90	7e-21	60.500	715	802	714	804	Immunoglobulin I-set domain
I-set	PF07679	90	9.5e-24	69.700	1126	1215	1126	1215	Immunoglobulin I-set domain
I-set	PF07679	90	2e-19	55.800	1266	1355	1266	1355	Immunoglobulin I-set domain
fn3	PF00041	85	2.4e-21	62.200	1362	1444	1360	1444	Fibronectin type III domain
Pkinase	PF00069	264	2.1e-81	259.200	1492	1747	1492	1747	Protein kinase domain
I-set	PF07679	90	1e-31	95.200	1837	1927	1837	1927	Immunoglobulin I-set domain

interactor

0.667

0.500

I-set (PF07679): Immunoglobulin I-set domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
fn3 (PF00041): Fibronectin type III domain
Pkinase (PF00069): Protein kinase domain

Myo6

XP_008825290.1

Domain structure obtained by HMM

Protein ID: XP_008825290.1 - unconventional myosin-VI isoform X4

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myosin_N	PF02736	40	0.000000099	18.100	5	40	4	41	Myosin N-terminal SH3-like domain
Myosin_head	PF00063	677	2.1e-244	798.700	59	759	59	759	Myosin head (motor domain)
IQ	PF00612	21	0.000001	14.800	815	834	814	834	IQ calmodulin-binding motif
IncA	PF04156	190	0.000052	9.300	843	925	841	928	IncA protein
PseudoU_synth_2	PF00849	161	0.000023	10.700	881	992	876	1026	RNA pseudouridylate synthase
Agouti	PF05039	91	0.0046	4.000	975	1018	970	1028	Agouti protein
Sec62	PF03839	217	0.00062	5.400	1079	1135	1078	1161	Translocation protein Sec62
Myosin-VI_CBD	PF16521	90	2.2e-47	145.400	1136	1226	1136	1226	Myosin VI cargo binding domain

interactor

0.667

1.000

Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
IncA (PF04156): IncA protein
PseudoU_synth_2 (PF00849): RNA pseudouridylate synthase
Agouti (PF05039): Agouti protein
Sec62 (PF03839): Translocation protein Sec62
Myosin-VI_CBD (PF16521): Myosin VI cargo binding domain

Pdlim3

XP_008851813.1

Domain structure obtained by HMM

Protein ID: XP_008851813.1 - PDZ and LIM domain protein 3 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PDZ	PF00595	82	2.4e-20	59.000	8	80	3	81	PDZ domain (Also known as DHR or GLGF)
DUF4749	PF15936	97	1.1e-27	83.400	137	215	137	224	Domain of unknown function (DUF4749)
LIM	PF00412	58	1.4e-17	50.000	246	296	246	301	LIM domain

interactor

PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936): Domain of unknown function (DUF4749)
LIM (PF00412): LIM domain

Pdx1

XP_008823288.1

Domain structure obtained by HMM

Protein ID: XP_008823288.1 - pancreas/duodenum homeobox protein 1
KEEG Ortholog ID: K07594

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Homeobox	PF00046	57	1.2e-25	75.500	147	203	147	203	Homeobox domain
TMEM171	PF15471	320	0.00085	4.400	222	271	198	277	Transmembrane protein family 171

oncogene, tumor suppressor

Homeobox (PF00046): Homeobox domain
TMEM171 (PF15471): Transmembrane protein family 171

Pik3cb

XP_008842332.1

Domain structure obtained by HMM

Protein ID: XP_008842332.1 - phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
KEEG Ortholog ID: K00922

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Tom37_C	PF11801	147	0.000015	11.200	11	58	7	87	Tom37 C-terminal domain
PI3K_p85B	PF02192	76	1.8e-35	106.900	42	116	42	117	PI3-kinase family, p85-binding domain
RWD	PF05773	116	0.0004	7.000	139	174	106	176	RWD domain
DUF4381	PF14316	146	0.00002	11.100	152	196	146	211	Domain of unknown function (DUF4381)
PI3K_rbd	PF00794	107	6.6e-35	105.800	182	287	180	288	PI3-kinase family, ras-binding domain
PI3K_C2	PF00792	136	8.1e-23	67.200	350	464	347	491	Phosphoinositide 3-kinase C2
RWD	PF05773	116	0.00011	8.700	507	595	462	646	RWD domain
PI3Ka	PF00613	185	3.1e-68	215.000	531	707	525	710	Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase	PF00454	250	1.6e-65	207.500	799	1015	798	1016	Phosphatidylinositol 3- and 4-kinase

interactor, oncogene

1.000

Tom37_C (PF11801): Tom37 C-terminal domain
PI3K_p85B (PF02192): PI3-kinase family, p85-binding domain
RWD (PF05773): RWD domain
DUF4381 (PF14316): Domain of unknown function (DUF4381)
PI3K_rbd (PF00794): PI3-kinase family, ras-binding domain
PI3K_C2 (PF00792): Phosphoinositide 3-kinase C2
PI3Ka (PF00613): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase

Pik3r1

XP_008837055.1

Domain structure obtained by HMM

Protein ID: XP_008837055.1 - phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
KEEG Ortholog ID: K02649

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_2	PF07653	55	0.000000019	20.300	8	75	7	77	Variant SH3 domain
PRIMA1	PF16101	121	0.0053	3.000	77	98	69	118	Proline-rich membrane anchor 1
Dscam_C	PF12355	118	0.041	1.100	84	109	64	114	Down syndrome cell adhesion molecule C terminal
RhoGAP	PF00620	152	2.5e-33	101.300	129	278	129	282	RhoGAP domain
Dscam_C	PF12355	118	0.00011	9.400	300	327	287	351	Down syndrome cell adhesion molecule C terminal
SH2	PF00017	77	4.5e-22	64.300	333	408	333	408	SH2 domain
PI3K_P85_iSH2	PF16454	161	1.3e-65	206.100	431	598	431	599	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SH2	PF00017	77	1.5e-24	72.200	624	698	624	698	SH2 domain

oncogene

0.436

26.350

SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

Plcb2

XP_008840540.1

Domain structure obtained by HMM

Protein ID: XP_008840540.1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
KEEG Ortholog ID: K05858

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
EF-hand_like	PF09279	86	0.00000000000021	37.000	214	304	211	305	Phosphoinositide-specific phospholipase C, efhand-like
PI-PLC-X	PF00388	145	2.4e-63	198.300	314	464	314	464	Phosphatidylinositol-specific phospholipase C, X domain
TRAP_alpha	PF03896	285	0.000011	10.800	495	577	484	592	Translocon-associated protein (TRAP), alpha subunit
PI-PLC-Y	PF00387	114	2.5e-43	133.400	546	661	546	661	Phosphatidylinositol-specific phospholipase C, Y domain
C2	PF00168	103	0.0000000000007	35.100	683	777	682	782	C2 domain
Ribosomal_60s	PF00428	88	0.0036	4.200	856	882	815	898	60s Acidic ribosomal protein
DUF1154	PF06631	45	0.000000071	18.700	888	915	885	923	Protein of unknown function (DUF1154)
PKK	PF12474	139	0.0011	5.300	900	932	891	934	Polo kinase kinase
PLC-beta_C	PF08703	176	3.2e-72	228.300	975	1149	974	1149	PLC-beta C terminal

oncogene

EF-hand_like (PF09279): Phosphoinositide-specific phospholipase C, efhand-like
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF1154 (PF06631): Protein of unknown function (DUF1154)
PKK (PF12474): Polo kinase kinase
PLC-beta_C (PF08703): PLC-beta C terminal

Plcg1

XP_008847808.1

Domain structure obtained by HMM

Protein ID: XP_008847808.1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
KEEG Ortholog ID: K01116

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PH_12	PF16457	134	0.000000017	21.300	63	141	40	142	Pleckstrin homology domain
PI-PLC-X	PF00388	145	1e-69	218.900	322	465	322	465	Phosphatidylinositol-specific phospholipase C, X domain
PH	PF00169	105	0.000017	11.600	490	534	489	548	PH domain
SH2	PF00017	77	2e-28	84.700	550	639	550	639	SH2 domain
SH2	PF00017	77	8.6e-24	69.800	668	741	668	741	SH2 domain
SH3_1	PF00018	48	4.7e-19	54.100	797	843	797	843	SH3 domain
PH	PF00169	105	0.00000054	16.400	873	929	864	931	PH domain
PI-PLC-Y	PF00387	114	9e-43	131.600	953	1069	953	1069	Phosphatidylinositol-specific phospholipase C, Y domain
C2	PF00168	103	7e-19	54.400	1090	1187	1088	1193	C2 domain

oncogene

0.619

5.583

PH_12 (PF16457): Pleckstrin homology domain
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
PH (PF00169): PH domain
SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain

Prkcq

XP_017651597.1

Domain structure obtained by HMM

Protein ID: XP_017651597.1 - protein kinase C theta type
KEEG Ortholog ID: K18052

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF1272	PF06906	57	0.0023	4.300	11	29	7	38	Protein of unknown function (DUF1272)
C1_1	PF00130	53	6.3e-16	44.400	160	210	155	212	Phorbol esters/diacylglycerol binding domain (C1 domain)
C1_1	PF00130	53	1.7e-20	59.000	232	283	232	284	Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase	PF00069	264	4.6e-65	205.700	382	634	380	634	Protein kinase domain
Pkinase_C	PF00433	46	0.0000000000003	36.600	655	696	655	696	Protein kinase C terminal domain

interactor

1.000

DUF1272 (PF06906): Protein of unknown function (DUF1272)
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain

Ptn

XP_008821696.1

Domain structure obtained by HMM

Protein ID: XP_008821696.1 - pleiotrophin isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
UPF0239	PF06783	88	0.00022	7.700	13	46	12	59	Uncharacterised protein family (UPF0239)
PTN_MK_N	PF05196	57	1.5e-30	91.600	34	95	34	95	PTN/MK heparin-binding protein family, N-terminal domain
PTN_MK_C	PF01091	65	8.6e-32	95.700	96	160	96	160	PTN/MK heparin-binding protein family, C-terminal domain
YqzE	PF14038	54	0.015	1.700	148	164	146	166	YqzE-like protein

oncogene

1.000

UPF0239 (PF06783): Uncharacterised protein family (UPF0239)
PTN_MK_N (PF05196): PTN/MK heparin-binding protein family, N-terminal domain
PTN_MK_C (PF01091): PTN/MK heparin-binding protein family, C-terminal domain
YqzE (PF14038): YqzE-like protein

Pxn

XP_008838716.1

Domain structure obtained by HMM

Protein ID: XP_008838716.1 - paxillin isoform X1
KEEG Ortholog ID: K05760

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Paxillin	PF03535	202	4.7e-97	309.900	44	253	44	253	Paxillin family
Gin	PF10764	45	0.029	0.700	349	365	342	371	Inhibitor of sigma-G Gin
LIM	PF00412	58	1.9e-22	65.600	358	412	358	413	LIM domain
LIM	PF00412	58	5.2e-21	61.000	417	472	417	472	LIM domain
LIM	PF00412	58	2.2e-20	59.000	476	530	476	531	LIM domain
LIM	PF00412	58	1.5e-18	53.100	535	589	535	590	LIM domain

oncogene

0.800

1.467

Paxillin (PF03535): Paxillin family
Gin (PF10764): Inhibitor of sigma-G Gin
LIM (PF00412): LIM domain

Rab35

XP_008838647.1

Domain structure obtained by HMM

Protein ID: XP_008838647.1 - ras-related protein Rab-35
KEEG Ortholog ID: K07876

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ras	PF00071	162	8.4e-60	187.200	25	177	24	179	Ras family

oncogene

Ras (PF00071): Ras family

Rack1

XP_008844172.1

Domain structure obtained by HMM

Protein ID: XP_008844172.1 - receptor of activated protein C kinase 1
KEEG Ortholog ID: K14753

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WD40	PF00400	38	0.00000015	18.500	8	44	5	44	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000000055	35.700	55	91	53	91	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000000041	36.100	97	133	95	133	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000022	24.300	146	178	136	178	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000029	23.900	188	220	182	220	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000068	22.800	225	260	224	260	WD domain, G-beta repeat
WD40	PF00400	38	0.00000017	18.400	286	310	273	311	WD domain, G-beta repeat

oncogene, tumor suppressor

0.667

2.000

WD40 (PF00400): WD domain, G-beta repeat

Rad17

XP_008837067.1

Domain structure obtained by HMM

Protein ID: XP_008837067.1 - cell cycle checkpoint protein RAD17 isoform X2
KEEG Ortholog ID: K06662

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mvb12	PF09452	90	0.000038	10.400	61	127	50	131	ESCRT-I subunit Mvb12
Rad17	PF03215	519	2.7e-229	748.400	86	593	83	593	Rad17 cell cycle checkpoint protein

interactor

Mvb12 (PF09452): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein

Shc1

XP_008852870.1

Domain structure obtained by HMM

Protein ID: XP_008852870.1 - SHC-transforming protein 1 isoform X1
KEEG Ortholog ID: K06279

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PID	PF00640	140	4.6e-51	158.700	162	317	162	318	Phosphotyrosine interaction domain (PTB/PID)
SH2	PF00017	77	9.1e-22	63.300	489	560	489	560	SH2 domain

oncogene

0.324

50.817

PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain

Shc3

XP_008821900.1

Domain structure obtained by HMM

Protein ID: XP_008821900.1 - SHC-transforming protein 3
KEEG Ortholog ID: K17448

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PID	PF00640	140	2.8e-53	165.900	153	308	153	309	Phosphotyrosine interaction domain (PTB/PID)
SH2	PF00017	77	3e-21	61.700	497	568	497	568	SH2 domain

interactor

1.000

PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain

Smc6

XP_017651362.1

Domain structure obtained by HMM

Protein ID: XP_017651362.1 - structural maintenance of chromosomes protein 6 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
AAA_23	PF13476	200	0.000000029	20.600	56	344	56	487	AAA domain
DASH_Spc19	PF08287	149	0.0000011	14.800	276	397	272	397	Spc19
DUF4988	PF16378	179	0.0000054	12.200	414	469	412	485	Domain of unknown function
Phage_GP20	PF06810	149	0.0033	3.400	442	481	428	486	Phage minor structural protein GP20
DUF16	PF01519	104	0.057	0.200	469	498	459	504	Protein of unknown function DUF16
Spc29	PF17082	244	0.0000068	12.200	631	707	627	717	Spindle Pole Component 29
TPR_MLP1_2	PF07926	129	0.000026	10.600	673	777	672	796	TPR/MLP1/MLP2-like protein
BLOC1_2	PF10046	96	0.00032	7.300	827	884	797	885	Biogenesis of lysosome-related organelles complex-1 subunit 2
Seryl_tRNA_N	PF02403	108	0.0002	7.900	862	919	856	929	Seryl-tRNA synthetase N-terminal domain
DUF3993	PF13158	118	0.00000041	16.500	885	934	879	940	Protein of unknown function (DUF3993)

interactor

AAA_23 (PF13476): AAA domain
DASH_Spc19 (PF08287): Spc19
DUF4988 (PF16378): Domain of unknown function
Phage_GP20 (PF06810): Phage minor structural protein GP20
DUF16 (PF01519): Protein of unknown function DUF16
Spc29 (PF17082): Spindle Pole Component 29
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046): Biogenesis of lysosome-related organelles complex-1 subunit 2
Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain
DUF3993 (PF13158): Protein of unknown function (DUF3993)

Socs1

XP_008828148.1

Domain structure obtained by HMM

Protein ID: XP_008828148.1 - suppressor of cytokine signaling 1
KEEG Ortholog ID: K04694

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SR-25	PF10500	227	0.000082	8.400	18	40	3	45	Nuclear RNA-splicing-associated protein
SH2	PF00017	77	0.0000000000001	37.500	85	160	85	160	SH2 domain
SOCS_box	PF07525	35	0.0000000018	24.200	177	211	177	213	SOCS box

oncogene, tumor suppressor

0.867

0.900

SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box

Socs5

XP_008821278.1

Domain structure obtained by HMM

Protein ID: XP_008821278.1 - suppressor of cytokine signaling 5
KEEG Ortholog ID: K04698

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SOCS	PF12610	59	1.3e-19	56.700	146	195	145	197	Suppressor of cytokine signalling
SH2	PF00017	77	0.00000000000091	34.500	382	436	381	459	SH2 domain
SOCS_box	PF07525	35	0.00000000000024	36.600	481	517	481	517	SOCS box

interactor

SOCS (PF12610): Suppressor of cytokine signalling
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box

Src

XP_008853894.1

Domain structure obtained by HMM

Protein ID: XP_008853894.1 - proto-oncogene tyrosine-protein kinase Src
KEEG Ortholog ID: K05704

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_1	PF00018	48	1e-17	49.800	90	143	90	143	SH3 domain
SH2	PF00017	77	1.5e-31	94.700	157	239	157	239	SH2 domain
Pkinase_Tyr	PF07714	260	5.4e-97	310.200	277	524	276	525	Protein tyrosine kinase

oncogene

0.301

73.783

SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Stat3

XP_008833515.1

Domain structure obtained by HMM

Protein ID: XP_008833515.1 - signal transducer and activator of transcription 3 isoform X1
KEEG Ortholog ID: K04692

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
STAT_int	PF02865	123	5.1e-42	129.500	2	119	2	120	STAT protein, protein interaction domain
STAT_alpha	PF01017	180	4e-60	188.900	141	319	141	319	STAT protein, all-alpha domain
STAT_bind	PF02864	248	2.7e-81	259.200	321	573	321	573	STAT protein, DNA binding domain
SH2	PF00017	77	2.4e-17	49.100	584	674	584	674	SH2 domain

oncogene, tumor suppressor

0.536

8.383

STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain

Tnk2

XP_008836758.1

Domain structure obtained by HMM

Protein ID: XP_008836758.1 - activated CDC42 kinase 1 isoform X1
KEEG Ortholog ID: K08886

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SAM_2	PF07647	66	0.00003	10.400	46	97	41	99	SAM domain (Sterile alpha motif)
Pkinase_Tyr	PF07714	260	9.1e-91	289.800	159	417	158	417	Protein tyrosine kinase
SH3_9	PF14604	49	0.0000000000000068	41.000	427	476	427	476	Variant SH3 domain
GTPase_binding	PF09027	68	1.1e-49	152.600	479	546	479	546	GTPase binding
Inhibitor_Mig-6	PF11555	60	1.5e-30	91.400	821	886	821	887	EGFR receptor inhibitor Mig-6
UBA_4	PF14555	43	0.00000024	16.800	1007	1040	1006	1041	UBA-like domain
UBA_4	PF14555	43	0.000004	12.900	1057	1072	1055	1075	UBA-like domain

interactor

0.667

4.500

SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SH3_9 (PF14604): Variant SH3 domain
GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain

Tubb4b

XP_008829427.1

Domain structure obtained by HMM

Protein ID: XP_008829427.1 - tubulin beta-4B chain
KEEG Ortholog ID: K07375

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Tubulin	PF00091	197	6.4e-73	231.300	3	211	3	212	Tubulin/FtsZ family, GTPase domain
Tubulin_C	PF03953	125	6.8e-47	145.100	261	381	261	382	Tubulin C-terminal domain

interactor

0.500

10.500

Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain

Tubgcp2

XP_008821393.1

Domain structure obtained by HMM

Protein ID: XP_008821393.1 - gamma-tubulin complex component 2 isoform X1
KEEG Ortholog ID: K16569

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF2894	PF11445	187	0.000017	11.500	65	156	27	159	Protein of unknown function (DUF2894)
Spc97_Spc98	PF04130	540	2.5e-125	405.300	219	737	219	737	Spc97 / Spc98 family
zf-Tim10_DDP	PF02953	64	0.0000026	13.400	715	770	710	773	Tim10/DDP family zinc finger

interactor

0.667

0.500

DUF2894 (PF11445): Protein of unknown function (DUF2894)
Spc97_Spc98 (PF04130): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger

Vim

XP_008832116.1

Domain structure obtained by HMM

Protein ID: XP_008832116.1 - vimentin
KEEG Ortholog ID: K07606

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Filament_head	PF04732	87	3.2e-24	72.000	7	101	6	101	Intermediate filament head (DNA binding) region
Filament	PF00038	312	6.9e-118	379.800	102	410	102	410	Intermediate filament protein

tumor suppressor

1.000

Filament_head (PF04732): Intermediate filament head (DNA binding) region
Filament (PF00038): Intermediate filament protein

Zc3hc1

XP_008844570.1

Domain structure obtained by HMM

Protein ID: XP_008844570.1 - nuclear-interacting partner of ALK isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-C3HC	PF07967	134	4.9e-39	119.600	73	199	72	201	C3HC zinc finger-like
Rsm1	PF08600	92	0.000000000000048	38.600	248	289	248	341	Rsm1-like
Yippee-Mis18	PF03226	105	0.00037	7.000	264	301	224	308	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Rsm1	PF08600	92	0.000000077	18.800	411	461	403	466	Rsm1-like

interactor

1.000

zf-C3HC (PF07967): C3HC zinc finger-like
Rsm1 (PF08600): Rsm1-like
Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

B a c k t o T o p ⇑