Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Alk (from a repository: Thu Jun 21 05:03:31 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins22 (36.07 %)
The number (and %) of the tumor suppressors10 (16.39 %)
Total number of binary PPIs (saturation %)214 (11.69 %)
The number (and %) of affected PPIs60 (28.04 %)
PPI diameter2
PPI radius1
The average degree of PPI6.131
Assortativity coefficient-0.4619
The network average Clustering coefficient0.545
The number (and %) of a zero Clustering coefficients12 (19.67 %)
The number (and %) of a zero Betweenness Centrality24 (39.34 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Alk

Domain structure obtained by HMM

Protein ID: XP_008844703.1 - ALK tyrosine kinase receptor
KEEG Ortholog ID: K05119
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MAMPF006291600.000000000001733.700269428269429MAM domain, meprin/A5/mu
Ldl_recept_aPF00057370.000005412.900442474440474Low-density lipoprotein receptor domain class A
MAMPF006291609.6e-2470.200483641483642MAM domain, meprin/A5/mu
Gly_richPF128102432e-2059.800736966731997Glycine rich protein
FXa_inhibitionPF14670360.000002614.00099210269901026Coagulation Factor Xa inhibitory site
Pkinase_TyrPF077142608.4e-93296.5001122138711211388Protein tyrosine kinase
user protein, oncogene600.0722735.633MAM (PF00629): MAM domain, meprin/A5/mu
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Actb

Domain structure obtained by HMM

Protein ID: XP_008849594.1 - actin, cytoplasmic 1
KEEG Ortholog ID: K05692
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ActinPF000224072.3e-155503.20033752375Actin
oncogene80.6196.000Actin (PF00022): Actin
Actn4

Domain structure obtained by HMM

Protein ID: XP_008852142.1 - alpha-actinin-4 isoform X1
KEEG Ortholog ID: K05699
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CHPF003071097.3e-2986.5005115450155Calponin homology (CH) domain
CHPF003071091.5e-3091.900164269163270Calponin homology (CH) domain
Uds1PF154561300.0350.500225307214312Up-regulated During Septation
SpectrinPF004351051.5e-1956.700293402293403Spectrin repeat
SpectrinPF004351054.8e-2780.800413517413518Spectrin repeat
SpectrinPF004351052.1e-2162.700529639528639Spectrin repeat
SpectrinPF004351052e-1749.900649751649752Spectrin repeat
EF-hand_7PF13499710.000000002823.700770835767836EF-hand domain pair
EFhand_Ca_insenPF08726697.6e-3192.400841907841907Ca2+ insensitive EF hand
interactor31.0000CH (PF00307): Calponin homology (CH) domain
Uds1 (PF15456): Up-regulated During Septation
Spectrin (PF00435): Spectrin repeat
EF-hand_7 (PF13499): EF-hand domain pair
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand
Bcar1

Domain structure obtained by HMM

Protein ID: XP_017651061.1 - breast cancer anti-estrogen resistance protein 1
KEEG Ortholog ID: K05726
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SH3_1PF00018487.4e-1850.300956957SH3 domain
Extensin_2PF04554580.0430.3009614592158Extensin-like region
Serine_richPF088241578.6e-48148.500458611458612Serine rich protein interaction domain
DUF3513PF120261955.4e-80254.100659868658868Domain of unknown function (DUF3513)
oncogene60.8671.000SH3_1 (PF00018): SH3 domain
Extensin_2 (PF04554): Extensin-like region
Serine_rich (PF08824): Serine rich protein interaction domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)
Bicd2

Domain structure obtained by HMM

Protein ID: XP_008851080.1 - protein bicaudal D homolog 2 isoform X1
KEEG Ortholog ID: K18739
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HALZPF02183430.0000769.20057794983Homeobox associated leucine zipper
BicDPF0973071901211.9008379783797Microtubule-associated protein Bicaudal-D
DUF4666PF156971110.0000669.900757832748837Domain of unknown function (DUF4666)
interactor100HALZ (PF02183): Homeobox associated leucine zipper
BicD (PF09730): Microtubule-associated protein Bicaudal-D
DUF4666 (PF15697): Domain of unknown function (DUF4666)
Cdk13

Domain structure obtained by HMM

Protein ID: XP_017654470.1 - cyclin-dependent kinase 13 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
K_channel_TIDPF07941740.0480.500162189158196Potassium channel Kv1.4 tandem inactivation domain
MacoilinPF097266710.0140.000176303149359Transmembrane protein
THRAP3_BCLAF1PF154406640.000000614.800395589392683THRAP3/BCLAF1 family
CPSF100_CPF132991690.0241.000544610531625Cleavage and polyadenylation factor 2 C-terminal
PkinasePF000692647.5e-78247.600708999706999Protein kinase domain
PRIMA1PF161011210.0270.80099510339851037Proline-rich membrane anchor 1
interactor40.8330.667K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
Macoilin (PF09726): Transmembrane protein
THRAP3_BCLAF1 (PF15440): THRAP3/BCLAF1 family
CPSF100_C (PF13299): Cleavage and polyadenylation factor 2 C-terminal
Pkinase (PF00069): Protein kinase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Cdk9

Domain structure obtained by HMM

Protein ID: XP_008823373.1 - cyclin-dependent kinase 9
KEEG Ortholog ID: K02211
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692642.8e-74235.9001931519315Protein kinase domain
interactor60.7002.167Pkinase (PF00069): Protein kinase domain
Cenpf

Domain structure obtained by HMM

Protein ID: XP_008823082.1 - centromere protein F isoform X1
KEEG Ortholog ID: K11499
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CENP-F_NPF104813071.3e-147477.40013061306Cenp-F N-terminal domain
Fez1PF068181980.00003810.300276432274441Fez1
TPR_MLP1_2PF079261290.000003613.300385496383497TPR/MLP1/MLP2-like protein
DivIVAPF051031310.00154.900478567474574DivIVA protein
bZIP_1PF00170640.000005412.800574615567616bZIP transcription factor
DUF1664PF078891240.00001511.200626686621696Protein of unknown function (DUF1664)
Tup_NPF08581770.000217.900714763707766Tup N-terminal
TPR_MLP1_2PF079261290.000006312.500857976851979TPR/MLP1/MLP2-like protein
Sec20PF03908920.0000699.10094510069391014Sec20
TPR_MLP1_2PF079261290.000227.60097610999741102TPR/MLP1/MLP2-like protein
DUF3450PF119322410.000127.6001118118411011191Protein of unknown function (DUF3450)
TMF_DNA_bdPF12329740.000386.8001205123211971238TATA element modulatory factor 1 DNA binding
DPM3PF08285910.00553.2001216124312081244Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Spc7PF083173100.00322.4001270134712531356Spc7 kinetochore protein
GIT_CCPF16559660.000138.3001390144413801447GIT coiled-coil Rho guanine nucleotide exchange factor
DUF972PF061561020.00264.7001415145813991472Protein of unknown function (DUF972)
Bcr-Abl_OligoPF09036730.000436.6001531157015241595Bcr-Abl oncoprotein oligomerisation domain
E2F_CC-MBPF16421920.0043.9001545158115371592E2F transcription factor CC-MB domain
CENP-QPF130941550.0112.1001574162915201699CENP-Q, a CENPA-CAD centromere complex subunit
HIP1_clath_bdgPF16515990.0112.7001599164515931661Clathrin-binding domain of Huntingtin-interacting protein 1
Cep57_MT_bdPF06657770.0122.4001622167115991674Centrosome microtubule-binding domain of Cep57
CLZPF16526710.00413.8001752180617481812C-terminal leucine zipper domain of cyclic nucleotide-gated channels
bZIP_1PF00170640.000925.6001815184318131851bZIP transcription factor
CENP-F_leu_zipPF104731400.00000000007428.4001881202318812023Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
APG6PF041113120.0000009414.5001950208519482091Autophagy protein Apg6
DUF5082PF168881230.00003110.6002023211720142119Domain of unknown function (DUF5082)
CENP-F_leu_zipPF104731405.1e-51158.6002119225821192258Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIPPF115591520.00174.7002260233722492339Afadin- and alpha -actinin-Binding
CENP-F_leu_zipPF104731408.6e-47144.9002302244023012440Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TPR_MLP1_2PF079261290.000005812.6002445257424422574TPR/MLP1/MLP2-like protein
Spc7PF083173100.0000009114.1002568273025642748Spc7 kinetochore protein
TMF_TATA_bdPF123251150.0000679.4002676275226702761TATA element modulatory factor 1 TATA binding
HALZPF02183430.00115.5002736276327342766Homeobox associated leucine zipper
CENP-F_C_Rb_bdgPF10490472.8e-2986.7002842288628402886Rb-binding domain of kinetochore protein Cenp-F/LEK1
oncogene31.0000CENP-F_N (PF10481): Cenp-F N-terminal domain
Fez1 (PF06818): Fez1
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
DivIVA (PF05103): DivIVA protein
bZIP_1 (PF00170): bZIP transcription factor
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Tup_N (PF08581): Tup N-terminal
Sec20 (PF03908): Sec20
DUF3450 (PF11932): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
DPM3 (PF08285): Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Spc7 (PF08317): Spc7 kinetochore protein
GIT_CC (PF16559): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF972 (PF06156): Protein of unknown function (DUF972)
Bcr-Abl_Oligo (PF09036): Bcr-Abl oncoprotein oligomerisation domain
E2F_CC-MB (PF16421): E2F transcription factor CC-MB domain
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Cep57_MT_bd (PF06657): Centrosome microtubule-binding domain of Cep57
CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
APG6 (PF04111): Autophagy protein Apg6
DUF5082 (PF16888): Domain of unknown function (DUF5082)
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
HALZ (PF02183): Homeobox associated leucine zipper
CENP-F_C_Rb_bdg (PF10490): Rb-binding domain of kinetochore protein Cenp-F/LEK1
Coro1c

Domain structure obtained by HMM

Protein ID: XP_008847173.1 - coronin-1C
KEEG Ortholog ID: K13886
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF1899PF08953665e-36108.800368368Domain of unknown function (DUF1899)
WD40PF00400380.000000001924.5007610869109WD domain, G-beta repeat
WD40PF00400380.000001415.400122159120159WD domain, G-beta repeat
ANAPC4_WD40PF12894920.00000115.300173213168226Anaphase-promoting complex subunit 4 WD40 domain
WD40_4PF16300445.3e-2676.600343385343385Type of WD40 repeat
oncogene41.0000DUF1899 (PF08953): Domain of unknown function (DUF1899)
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
Eif4b

Domain structure obtained by HMM

Protein ID: XP_008836569.1 - eukaryotic translation initiation factor 4B isoform X1
KEEG Ortholog ID: K03258
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076707.8e-1747.2009916798167RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774PF12609750.00673.800329378321386Wound-induced protein
interactor31.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609): Wound-induced protein
Epha1

Domain structure obtained by HMM

Protein ID: XP_008826846.1 - ephrin type-A receptor 1
KEEG Ortholog ID: K05102
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ephrin_lbdPF014041788.6e-60188.0002820428204Ephrin receptor ligand binding domain
Ephrin_rec_likePF07699480.000000002523.100272309267313Putative ephrin-receptor like
fn3PF00041851.3e-2059.900334427334431Fibronectin type III domain
fn3PF00041850.0000000004626.100457528450528Fibronectin type III domain
EphA2_TMPF14575772.2e-1956.400548620548620Ephrin type-A receptor 2 transmembrane domain
Pkinase_TyrPF077142606.6e-98313.200624879623879Protein tyrosine kinase
SAM_1PF00536641e-2679.500913974910974SAM domain (Sterile alpha motif)
oncogene, tumor suppressor30.6670.500Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Ephb2

Domain structure obtained by HMM

Protein ID: XP_008846790.1 - ephrin type-B receptor 2 isoform X1
KEEG Ortholog ID: K05111
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ephrin_lbdPF014041782e-76242.10011741174Ephrin receptor ligand binding domain
EGF_2PF07974320.00002311.000216238211246EGF-like domain
cEGFPF12662240.0000449.700230247230247Complement Clr-like EGF-like
Ephrin_rec_likePF07699480.00000000003529.100245279238282Putative ephrin-receptor like
EGF_2PF07974320.00733.000276287255290EGF-like domain
fn3PF00041852.8e-2162.000303398303398Fibronectin type III domain
fn3PF00041853.6e-2058.400415497411497Fibronectin type III domain
EphA2_TMPF14575773e-2781.600521595521596Ephrin type-A receptor 2 transmembrane domain
Pkinase_TyrPF077142602.3e-102327.800600858599858Protein tyrosine kinase
SAM_1PF00536641.4e-2472.600890952889953SAM domain (Sterile alpha motif)
tumor suppressor41.0000Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Errfi1

Domain structure obtained by HMM

Protein ID: XP_008820670.1 - ERBB receptor feedback inhibitor 1 isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
GTPase_bindingPF09027680.00000009718.300441454GTPase binding
Inhibitor_Mig-6PF11555600.00423.500279291252308EGFR receptor inhibitor Mig-6
Inhibitor_Mig-6PF11555605.9e-1954.300313367313369EGFR receptor inhibitor Mig-6
oncogene, tumor suppressor60.8000.917GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6
Flii

Domain structure obtained by HMM

Protein ID: XP_008820183.1 - protein flightless-1 homolog isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LRR_4PF12799430.0152.20013421053Leucine Rich repeats (2 copies)
LRR_8PF13855610.00000000002529.50034913391Leucine rich repeat
LRR_8PF13855610.000000001224.2009513992139Leucine rich repeat
LRR_8PF13855610.00000000000005638.000131186127186Leucine rich repeat
LRR_4PF12799430.000178.300175210174224Leucine Rich repeats (2 copies)
LRR_8PF13855610.0000000000002735.800200258198258Leucine rich repeat
LRR_4PF12799430.00000000002929.900271310269311Leucine Rich repeats (2 copies)
LRR_8PF13855610.0000002316.800315352307366Leucine rich repeat
LRR_1PF00560230.0162.600341361341362Leucine Rich Repeat
SRP-alpha_NPF040862920.0000004216.200387458366474Signal recognition particle, alpha subunit, N-terminal
GelsolinPF00626761.5e-1956.000478560477560Gelsolin repeat
GelsolinPF00626761.2e-1749.900598672597672Gelsolin repeat
GelsolinPF00626760.0000000001327.400730800725801Gelsolin repeat
GelsolinPF00626760.00000214.00089410008891000Gelsolin repeat
GelsolinPF00626760.0000000718.6001044111210381113Gelsolin repeat
GelsolinPF00626760.0000000000001836.6001149122311461224Gelsolin repeat
oncogene40.6670.900LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
Gelsolin (PF00626): Gelsolin repeat
Gak

Domain structure obtained by HMM

Protein ID: XP_008840005.1 - cyclin-G-associated kinase isoform X1
KEEG Ortholog ID: K08855
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692649.5e-52162.0004331140313Protein kinase domain
Y_phosphatasePF001022350.00002110.300473533434563Protein-tyrosine phosphatase
DSPcPF007821330.00001910.700498547480558Dual specificity phosphatase, catalytic domain
PTEN_C2PF104091352.9e-33100.700571707570709C2 domain of PTEN tumour-suppressor protein
DnaJPF00226630.00000000004729.0001245129712391300DnaJ domain
oncogene30.6671.000Pkinase (PF00069): Protein kinase domain
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
DnaJ (PF00226): DnaJ domain
Grb2

Domain structure obtained by HMM

Protein ID: XP_008829635.1 - growth factor receptor-bound protein 2
KEEG Ortholog ID: K04364
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SH3_1PF00018481.5e-2058.900450450SH3 domain
SH2PF00017776.1e-2986.3006013560135SH2 domain
DUF5093PF170111310.000002314.2009815590165Domain of unknown function (DUF5093)
SH3_1PF00018481.3e-2059.100162206162207SH3 domain
oncogene230.264133.533SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Hsp90aa1

Domain structure obtained by HMM

Protein ID: XP_008823821.1 - heat shock protein HSP 90-alpha
KEEG Ortholog ID: K04079
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HATPase_cPF025181117.3e-1851.5004019340194Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90PF001835182.9e-246804.200196716196723Hsp90 protein
oncogene190.26889.483HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Hspd1

Domain structure obtained by HMM

Protein ID: XP_008846515.2 - 60 kDa heat shock protein, mitochondrial
KEEG Ortholog ID: K04077
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cpn60_TCP1PF001184914.6e-90288.6004754847550TCP-1/cpn60 chaperonin family
oncogene, tumor suppressor50.7002.000Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family
Ikbkg

Domain structure obtained by HMM

Protein ID: XP_017652770.1 - NF-kappa-B essential modulator isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NEMOPF11577686.8e-3295.7004411144111NF-kappa-B essential modulator NEMO
APC_u15PF16636810.000008512.500107146105161Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5PF097873060.000001414.100152285139289Golgin subfamily A member 5
CC2-LZPF165161042.6e-33100.800248343239343Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1PF149451190.0000211.400302360300386Normal lung function maintenance, Low in Lung Cancer 1 protein
interactor100.38917.900NEMO (PF11577): NF-kappa-B essential modulator NEMO
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5 (PF09787): Golgin subfamily A member 5
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1 (PF14945): Normal lung function maintenance, Low in Lung Cancer 1 protein
Irf7

Domain structure obtained by HMM

Protein ID: XP_008852618.1 - interferon regulatory factor 7 isoform X2
KEEG Ortholog ID: K09447
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IRFPF006051055.1e-41125.5001212111122Interferon regulatory factor transcription factor
IRF-3PF104011804e-50156.200243421242422Interferon-regulatory factor 3
interactor200IRF (PF00605): Interferon regulatory factor transcription factor
IRF-3 (PF10401): Interferon-regulatory factor 3
Irs1

Domain structure obtained by HMM

Protein ID: XP_008824062.1 - insulin receptor substrate 1
KEEG Ortholog ID: K16172
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PHPF001691050.00000000000007338.500221119114PH domain
IRSPF021741002.8e-35106.600157257156258PTB domain (IRS-1 type)
interactor70.7143.833PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)
Irs4

Domain structure obtained by HMM

Protein ID: XP_008851185.1 - insulin receptor substrate 4
KEEG Ortholog ID: K17446
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TAT_signalPF10518260.0430.20015321533TAT (twin-arginine translocation) pathway signal sequence
PH_11PF154131050.0000007615.8008319682198Pleckstrin homology domain
IRSPF021741003.4e-3399.800234334233335PTB domain (IRS-1 type)
CAP_NPF012133170.00001910.400634654614669Adenylate cyclase associated (CAP) N terminal
CAP_NPF012133170.00253.400765788736798Adenylate cyclase associated (CAP) N terminal
Ribosomal_60sPF00428880.00294.500121412561189126160s Acidic ribosomal protein
interactor40.8330.250TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
IRS (PF02174): PTB domain (IRS-1 type)
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Jak2

Domain structure obtained by HMM

Protein ID: XP_008839879.1 - tyrosine-protein kinase JAK2 isoform X2
KEEG Ortholog ID: K04447
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FERM_MPF003731180.0000002817.200143262140269FERM central domain
SH2PF00017770.00000000006328.600401481400481SH2 domain
Pkinase_TyrPF077142602.8e-66209.500546805545805Protein tyrosine kinase
Pkinase_TyrPF077142607.9e-90286.70084911208491123Protein tyrosine kinase
oncogene140.50022.533FERM_M (PF00373): FERM central domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Jak3

Domain structure obtained by HMM

Protein ID: XP_008822806.1 - tyrosine-protein kinase JAK3
KEEG Ortholog ID: K11218
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
APHPF016362400.0220.7009924467263Phosphotransferase enzyme family
SH2PF00017770.00000214.100377454376456SH2 domain
Pkinase_TyrPF077142601.2e-56177.900521777521777Protein tyrosine kinase
Pkinase_TyrPF077142602.2e-82262.30082310948221095Protein tyrosine kinase
oncogene50.7001.567APH (PF01636): Phosphotransferase enzyme family
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Krt18

Domain structure obtained by HMM

Protein ID: XP_008836537.1 - keratin, type I cytoskeletal 18
KEEG Ortholog ID: K07604
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FilamentPF000383123.9e-107344.5007338372385Intermediate filament protein
Spc7PF083173100.000007611.000333408326418Spc7 kinetochore protein
interactor80.38110.067Filament (PF00038): Intermediate filament protein
Spc7 (PF08317): Spc7 kinetochore protein
Map2k7

Domain structure obtained by HMM

Protein ID: XP_008822354.1 - dual specificity mitogen-activated protein kinase kinase 7 isoform X1
KEEG Ortholog ID: K04431
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692642.9e-60189.900161420160420Protein kinase domain
interactor60.6003.567Pkinase (PF00069): Protein kinase domain
Map3k1

Domain structure obtained by HMM

Protein ID: XP_008838602.1 - mitogen-activated protein kinase kinase kinase 1
KEEG Ortholog ID: K04416
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Phostensin_NPF13916860.000005812.900189219183232PP1-regulatory protein, Phostensin N-terminal
zf-Di19PF05605540.0520.200433444427469Drought induced 19 protein (Di19), zinc-binding
zf-RING_2PF13639440.000000001124.700439489438489Ring finger domain
zf-Di19PF05605540.000327.300474500455503Drought induced 19 protein (Di19), zinc-binding
PkinasePF000692642.7e-70222.8001231149412291494Protein kinase domain
oncogene70.4675.567Phostensin_N (PF13916): PP1-regulatory protein, Phostensin N-terminal
zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639): Ring finger domain
Pkinase (PF00069): Protein kinase domain
Map3k5

Domain structure obtained by HMM

Protein ID: XP_008820276.1 - mitogen-activated protein kinase kinase kinase 5 isoform X2
KEEG Ortholog ID: K04426
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF4071PF132813683.4e-161522.400169549169549Domain of unknown function (DUF4071)
PkinasePF000692643.3e-68216.000689941686942Protein kinase domain
FPPPF059118740.0000004214.6001080129110341295Filament-like plant protein, long coiled-coil
oncogene80.5716.250DUF4071 (PF13281): Domain of unknown function (DUF4071)
Pkinase (PF00069): Protein kinase domain
FPP (PF05911): Filament-like plant protein, long coiled-coil
Mapk1

Domain structure obtained by HMM

Protein ID: XP_008840426.1 - mitogen-activated protein kinase 1
KEEG Ortholog ID: K04371
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692644e-73232.1001330113301Protein kinase domain
oncogene90.35713.317Pkinase (PF00069): Protein kinase domain
Mapk8ip3

Domain structure obtained by HMM

Protein ID: XP_008854413.1 - C-Jun-amino-terminal kinase-interacting protein 3 isoform X1
KEEG Ortholog ID: K04436
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Jnk-SapK_ap_NPF097441567.9e-61191.0002918429184JNK_SAPK-associated protein-1
JIP_LZIIPF16471712.1e-33100.700423493423493JNK-interacting protein leucine zipper II
Med21PF112211440.0000679.400441516427519Subunit 21 of Mediator complex
ERMPF007692430.0000968.400464665437671Ezrin/radixin/moesin family
UPF0449PF151361010.0122.400646688626696Uncharacterised protein family UPF0449
interactor50.6002.067Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
Med21 (PF11221): Subunit 21 of Mediator complex
ERM (PF00769): Ezrin/radixin/moesin family
UPF0449 (PF15136): Uncharacterised protein family UPF0449
Mep1b

Domain structure obtained by HMM

Protein ID: XP_008827082.1 - meprin A subunit beta
KEEG Ortholog ID: K08606
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
AstacinPF014001914.9e-75237.5007125770258Astacin (Peptidase family M12A)
MAMPF006291601.2e-41128.500266429266429MAM domain, meprin/A5/mu
EGFPF00008320.0000001518.000615641615654EGF-like domain
LRRC37AB_CPF149141470.0000111.700658689651691LRRC37A/B like protein 1 C-terminal domain
interactor100Astacin (PF01400): Astacin (Peptidase family M12A)
MAM (PF00629): MAM domain, meprin/A5/mu
EGF (PF00008): EGF-like domain
LRRC37AB_C (PF14914): LRRC37A/B like protein 1 C-terminal domain
Mtif2

Domain structure obtained by HMM

Protein ID: XP_008821228.1 - translation initiation factor IF-2, mitochondrial
KEEG Ortholog ID: K02519
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
GTP_EFTUPF000091944.4e-36110.400184341180345Elongation factor Tu GTP binding domain
GTP_EFTU_D4PF14578860.0350.500377419355422Elongation factor Tu domain 4
Dynamin_NPF003501680.00194.400433488368541Dynamin family
IF-2PF119871052e-34104.200511607502608Translation-initiation factor 2
GTP_EFTU_D4PF14578860.0000419.800644702629711Elongation factor Tu domain 4
interactor100GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4
Dynamin_N (PF00350): Dynamin family
IF-2 (PF11987): Translation-initiation factor 2
Mybpc2

Domain structure obtained by HMM

Protein ID: XP_008843370.1 - myosin-binding protein C, fast-type
KEEG Ortholog ID: K12558
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
I-setPF07679900.0000000002426.7005013748149Immunoglobulin I-set domain
I-setPF07679900.000000000001433.900253328251333Immunoglobulin I-set domain
I-setPF07679900.0000000000003635.700343418341430Immunoglobulin I-set domain
I-setPF07679900.00000000000002139.700436506434519Immunoglobulin I-set domain
I-setPF07679902.4e-1955.600547630542630Immunoglobulin I-set domain
fn3PF00041857.1e-1851.100635720635720Fibronectin type III domain
fn3PF00041852.3e-1646.300733816733818Fibronectin type III domain
I-setPF07679906.2e-1644.600847924838924Immunoglobulin I-set domain
fn3PF00041854.8e-1851.60093010079291012Fibronectin type III domain
I-setPF07679905.2e-2470.5001043113210431132Immunoglobulin I-set domain
interactor100I-set (PF07679): Immunoglobulin I-set domain
fn3 (PF00041): Fibronectin type III domain
Myh10

Domain structure obtained by HMM

Protein ID: XP_017650498.1 - myosin-10
KEEG Ortholog ID: K10352
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myosin_NPF02736401.5e-1646.30033733373Myosin N-terminal SH3-like domain
Myosin_headPF0006367701015.7008780287802Myosin head (motor domain)
IQPF00612210.00000001720.300819837818838IQ calmodulin-binding motif
Myosin_tail_1PF0157610814.2e-199649.90087913178791318Myosin tail
Myosin_tail_1PF0157610811.6e-278912.9001315187313131873Myosin tail
interactor31.0000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Myh9

Domain structure obtained by HMM

Protein ID: XP_008853014.1 - myosin-9 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myosin_NPF02736400.000000000000137.20029692969Myosin N-terminal SH3-like domain
Myosin_headPF0006367701022.2008376483764Myosin head (motor domain)
IQPF00612210.00000006918.400783799780800IQ calmodulin-binding motif
Myosin_tail_1PF01576108101675.80084119218411921Myosin tail
oncogene, tumor suppressor120.31839.000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Mylk

Domain structure obtained by HMM

Protein ID: XP_017656046.1 - myosin light chain kinase, smooth muscle isoform X1
KEEG Ortholog ID: K00907
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
I-setPF07679903.5e-2367.8003312333123Immunoglobulin I-set domain
I-setPF07679901.3e-2782.000161250161250Immunoglobulin I-set domain
23ISLPF166201623.8e-64202.000252403251406Unstructured linker between I-set domains 2 and 3 on MYLCK
I-setPF07679902.1e-2471.800407497407497Immunoglobulin I-set domain
I-setPF07679901.5e-2369.000507593507593Immunoglobulin I-set domain
I-setPF07679902.2e-2678.100617705616705Immunoglobulin I-set domain
I-setPF07679907e-2160.500715802714804Immunoglobulin I-set domain
I-setPF07679909.5e-2469.7001126121511261215Immunoglobulin I-set domain
I-setPF07679902e-1955.8001266135512661355Immunoglobulin I-set domain
fn3PF00041852.4e-2162.2001362144413601444Fibronectin type III domain
PkinasePF000692642.1e-81259.2001492174714921747Protein kinase domain
I-setPF07679901e-3195.2001837192718371927Immunoglobulin I-set domain
interactor30.6670.500I-set (PF07679): Immunoglobulin I-set domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
fn3 (PF00041): Fibronectin type III domain
Pkinase (PF00069): Protein kinase domain
Myo6

Domain structure obtained by HMM

Protein ID: XP_008825290.1 - unconventional myosin-VI isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myosin_NPF02736400.00000009918.100540441Myosin N-terminal SH3-like domain
Myosin_headPF000636772.1e-244798.7005975959759Myosin head (motor domain)
IQPF00612210.00000114.800815834814834IQ calmodulin-binding motif
IncAPF041561900.0000529.300843925841928IncA protein
PseudoU_synth_2PF008491610.00002310.7008819928761026RNA pseudouridylate synthase
AgoutiPF05039910.00464.00097510189701028Agouti protein
Sec62PF038392170.000625.4001079113510781161Translocation protein Sec62
Myosin-VI_CBDPF16521902.2e-47145.4001136122611361226Myosin VI cargo binding domain
interactor40.6671.000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
IncA (PF04156): IncA protein
PseudoU_synth_2 (PF00849): RNA pseudouridylate synthase
Agouti (PF05039): Agouti protein
Sec62 (PF03839): Translocation protein Sec62
Myosin-VI_CBD (PF16521): Myosin VI cargo binding domain
Pdlim3

Domain structure obtained by HMM

Protein ID: XP_008851813.1 - PDZ and LIM domain protein 3 isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PDZPF00595822.4e-2059.000880381PDZ domain (Also known as DHR or GLGF)
DUF4749PF15936971.1e-2783.400137215137224Domain of unknown function (DUF4749)
LIMPF00412581.4e-1750.000246296246301LIM domain
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936): Domain of unknown function (DUF4749)
LIM (PF00412): LIM domain
Pdx1

Domain structure obtained by HMM

Protein ID: XP_008823288.1 - pancreas/duodenum homeobox protein 1
KEEG Ortholog ID: K07594
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HomeoboxPF00046571.2e-2575.500147203147203Homeobox domain
TMEM171PF154713200.000854.400222271198277Transmembrane protein family 171
oncogene, tumor suppressor100Homeobox (PF00046): Homeobox domain
TMEM171 (PF15471): Transmembrane protein family 171
Pik3cb

Domain structure obtained by HMM

Protein ID: XP_008842332.1 - phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
KEEG Ortholog ID: K00922
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Tom37_CPF118011470.00001511.2001158787Tom37 C-terminal domain
PI3K_p85BPF02192761.8e-35106.9004211642117PI3-kinase family, p85-binding domain
RWDPF057731160.00047.000139174106176RWD domain
DUF4381PF143161460.0000211.100152196146211Domain of unknown function (DUF4381)
PI3K_rbdPF007941076.6e-35105.800182287180288PI3-kinase family, ras-binding domain
PI3K_C2PF007921368.1e-2367.200350464347491Phosphoinositide 3-kinase C2
RWDPF057731160.000118.700507595462646RWD domain
PI3KaPF006131853.1e-68215.000531707525710Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinasePF004542501.6e-65207.50079910157981016Phosphatidylinositol 3- and 4-kinase
interactor, oncogene41.0000Tom37_C (PF11801): Tom37 C-terminal domain
PI3K_p85B (PF02192): PI3-kinase family, p85-binding domain
RWD (PF05773): RWD domain
DUF4381 (PF14316): Domain of unknown function (DUF4381)
PI3K_rbd (PF00794): PI3-kinase family, ras-binding domain
PI3K_C2 (PF00792): Phosphoinositide 3-kinase C2
PI3Ka (PF00613): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase
Pik3r1

Domain structure obtained by HMM

Protein ID: XP_008837055.1 - phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
KEEG Ortholog ID: K02649
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SH3_2PF07653550.00000001920.300875777Variant SH3 domain
PRIMA1PF161011210.00533.000779869118Proline-rich membrane anchor 1
Dscam_CPF123551180.0411.1008410964114Down syndrome cell adhesion molecule C terminal
RhoGAPPF006201522.5e-33101.300129278129282RhoGAP domain
Dscam_CPF123551180.000119.400300327287351Down syndrome cell adhesion molecule C terminal
SH2PF00017774.5e-2264.300333408333408SH2 domain
PI3K_P85_iSH2PF164541611.3e-65206.100431598431599Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SH2PF00017771.5e-2472.200624698624698SH2 domain
oncogene140.43626.350SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Plcb2

Domain structure obtained by HMM

Protein ID: XP_008840540.1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
KEEG Ortholog ID: K05858
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
EF-hand_likePF09279860.0000000000002137.000214304211305Phosphoinositide-specific phospholipase C, efhand-like
PI-PLC-XPF003881452.4e-63198.300314464314464Phosphatidylinositol-specific phospholipase C, X domain
TRAP_alphaPF038962850.00001110.800495577484592Translocon-associated protein (TRAP), alpha subunit
PI-PLC-YPF003871142.5e-43133.400546661546661Phosphatidylinositol-specific phospholipase C, Y domain
C2PF001681030.000000000000735.100683777682782C2 domain
Ribosomal_60sPF00428880.00364.20085688281589860s Acidic ribosomal protein
DUF1154PF06631450.00000007118.700888915885923Protein of unknown function (DUF1154)
PKKPF124741390.00115.300900932891934Polo kinase kinase
PLC-beta_CPF087031763.2e-72228.30097511499741149PLC-beta C terminal
oncogene200EF-hand_like (PF09279): Phosphoinositide-specific phospholipase C, efhand-like
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF1154 (PF06631): Protein of unknown function (DUF1154)
PKK (PF12474): Polo kinase kinase
PLC-beta_C (PF08703): PLC-beta C terminal
Plcg1

Domain structure obtained by HMM

Protein ID: XP_008847808.1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
KEEG Ortholog ID: K01116
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PH_12PF164571340.00000001721.3006314140142Pleckstrin homology domain
PI-PLC-XPF003881451e-69218.900322465322465Phosphatidylinositol-specific phospholipase C, X domain
PHPF001691050.00001711.600490534489548PH domain
SH2PF00017772e-2884.700550639550639SH2 domain
SH2PF00017778.6e-2469.800668741668741SH2 domain
SH3_1PF00018484.7e-1954.100797843797843SH3 domain
PHPF001691050.0000005416.400873929864931PH domain
PI-PLC-YPF003871149e-43131.60095310699531069Phosphatidylinositol-specific phospholipase C, Y domain
C2PF001681037e-1954.4001090118710881193C2 domain
oncogene70.6195.583PH_12 (PF16457): Pleckstrin homology domain
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
PH (PF00169): PH domain
SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Prkcq

Domain structure obtained by HMM

Protein ID: XP_017651597.1 - protein kinase C theta type
KEEG Ortholog ID: K18052
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF1272PF06906570.00234.3001129738Protein of unknown function (DUF1272)
C1_1PF00130536.3e-1644.400160210155212Phorbol esters/diacylglycerol binding domain (C1 domain)
C1_1PF00130531.7e-2059.000232283232284Phorbol esters/diacylglycerol binding domain (C1 domain)
PkinasePF000692644.6e-65205.700382634380634Protein kinase domain
Pkinase_CPF00433460.000000000000336.600655696655696Protein kinase C terminal domain
interactor41.0000DUF1272 (PF06906): Protein of unknown function (DUF1272)
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Ptn

Domain structure obtained by HMM

Protein ID: XP_008821696.1 - pleiotrophin isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UPF0239PF06783880.000227.70013461259Uncharacterised protein family (UPF0239)
PTN_MK_NPF05196571.5e-3091.60034953495PTN/MK heparin-binding protein family, N-terminal domain
PTN_MK_CPF01091658.6e-3295.7009616096160PTN/MK heparin-binding protein family, C-terminal domain
YqzEPF14038540.0151.700148164146166YqzE-like protein
oncogene31.0000UPF0239 (PF06783): Uncharacterised protein family (UPF0239)
PTN_MK_N (PF05196): PTN/MK heparin-binding protein family, N-terminal domain
PTN_MK_C (PF01091): PTN/MK heparin-binding protein family, C-terminal domain
YqzE (PF14038): YqzE-like protein
Pxn

Domain structure obtained by HMM

Protein ID: XP_008838716.1 - paxillin isoform X1
KEEG Ortholog ID: K05760
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PaxillinPF035352024.7e-97309.9004425344253Paxillin family
GinPF10764450.0290.700349365342371Inhibitor of sigma-G Gin
LIMPF00412581.9e-2265.600358412358413LIM domain
LIMPF00412585.2e-2161.000417472417472LIM domain
LIMPF00412582.2e-2059.000476530476531LIM domain
LIMPF00412581.5e-1853.100535589535590LIM domain
oncogene60.8001.467Paxillin (PF03535): Paxillin family
Gin (PF10764): Inhibitor of sigma-G Gin
LIM (PF00412): LIM domain
Rab35

Domain structure obtained by HMM

Protein ID: XP_008838647.1 - ras-related protein Rab-35
KEEG Ortholog ID: K07876
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RasPF000711628.4e-60187.2002517724179Ras family
oncogene100Ras (PF00071): Ras family
Rack1

Domain structure obtained by HMM

Protein ID: XP_008844172.1 - receptor of activated protein C kinase 1
KEEG Ortholog ID: K14753
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
WD40PF00400380.0000001518.500844544WD domain, G-beta repeat
WD40PF00400380.0000000000005535.70055915391WD domain, G-beta repeat
WD40PF00400380.0000000000004136.1009713395133WD domain, G-beta repeat
WD40PF00400380.000000002224.300146178136178WD domain, G-beta repeat
WD40PF00400380.000000002923.900188220182220WD domain, G-beta repeat
WD40PF00400380.000000006822.800225260224260WD domain, G-beta repeat
WD40PF00400380.0000001718.400286310273311WD domain, G-beta repeat
oncogene, tumor suppressor50.6672.000WD40 (PF00400): WD domain, G-beta repeat
Rad17

Domain structure obtained by HMM

Protein ID: XP_008837067.1 - cell cycle checkpoint protein RAD17 isoform X2
KEEG Ortholog ID: K06662
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mvb12PF09452900.00003810.4006112750131ESCRT-I subunit Mvb12
Rad17PF032155192.7e-229748.4008659383593Rad17 cell cycle checkpoint protein
interactor100Mvb12 (PF09452): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Shc1

Domain structure obtained by HMM

Protein ID: XP_008852870.1 - SHC-transforming protein 1 isoform X1
KEEG Ortholog ID: K06279
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PIDPF006401404.6e-51158.700162317162318Phosphotyrosine interaction domain (PTB/PID)
SH2PF00017779.1e-2263.300489560489560SH2 domain
oncogene160.32450.817PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Shc3

Domain structure obtained by HMM

Protein ID: XP_008821900.1 - SHC-transforming protein 3
KEEG Ortholog ID: K17448
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PIDPF006401402.8e-53165.900153308153309Phosphotyrosine interaction domain (PTB/PID)
SH2PF00017773e-2161.700497568497568SH2 domain
interactor21.0000PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Smc6

Domain structure obtained by HMM

Protein ID: XP_017651362.1 - structural maintenance of chromosomes protein 6 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
AAA_23PF134762000.00000002920.6005634456487AAA domain
DASH_Spc19PF082871490.000001114.800276397272397Spc19
DUF4988PF163781790.000005412.200414469412485Domain of unknown function
Phage_GP20PF068101490.00333.400442481428486Phage minor structural protein GP20
DUF16PF015191040.0570.200469498459504Protein of unknown function DUF16
Spc29PF170822440.000006812.200631707627717Spindle Pole Component 29
TPR_MLP1_2PF079261290.00002610.600673777672796TPR/MLP1/MLP2-like protein
BLOC1_2PF10046960.000327.300827884797885Biogenesis of lysosome-related organelles complex-1 subunit 2
Seryl_tRNA_NPF024031080.00027.900862919856929Seryl-tRNA synthetase N-terminal domain
DUF3993PF131581180.0000004116.500885934879940Protein of unknown function (DUF3993)
interactor200AAA_23 (PF13476): AAA domain
DASH_Spc19 (PF08287): Spc19
DUF4988 (PF16378): Domain of unknown function
Phage_GP20 (PF06810): Phage minor structural protein GP20
DUF16 (PF01519): Protein of unknown function DUF16
Spc29 (PF17082): Spindle Pole Component 29
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046): Biogenesis of lysosome-related organelles complex-1 subunit 2
Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain
DUF3993 (PF13158): Protein of unknown function (DUF3993)
Socs1

Domain structure obtained by HMM

Protein ID: XP_008828148.1 - suppressor of cytokine signaling 1
KEEG Ortholog ID: K04694
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SR-25PF105002270.0000828.4001840345Nuclear RNA-splicing-associated protein
SH2PF00017770.000000000000137.5008516085160SH2 domain
SOCS_boxPF07525350.000000001824.200177211177213SOCS box
oncogene, tumor suppressor60.8670.900SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Socs5

Domain structure obtained by HMM

Protein ID: XP_008821278.1 - suppressor of cytokine signaling 5
KEEG Ortholog ID: K04698
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SOCSPF12610591.3e-1956.700146195145197Suppressor of cytokine signalling
SH2PF00017770.0000000000009134.500382436381459SH2 domain
SOCS_boxPF07525350.0000000000002436.600481517481517SOCS box
interactor100SOCS (PF12610): Suppressor of cytokine signalling
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Src

Domain structure obtained by HMM

Protein ID: XP_008853894.1 - proto-oncogene tyrosine-protein kinase Src
KEEG Ortholog ID: K05704
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SH3_1PF00018481e-1749.8009014390143SH3 domain
SH2PF00017771.5e-3194.700157239157239SH2 domain
Pkinase_TyrPF077142605.4e-97310.200277524276525Protein tyrosine kinase
oncogene180.30173.783SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Stat3

Domain structure obtained by HMM

Protein ID: XP_008833515.1 - signal transducer and activator of transcription 3 isoform X1
KEEG Ortholog ID: K04692
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
STAT_intPF028651235.1e-42129.50021192120STAT protein, protein interaction domain
STAT_alphaPF010171804e-60188.900141319141319STAT protein, all-alpha domain
STAT_bindPF028642482.7e-81259.200321573321573STAT protein, DNA binding domain
SH2PF00017772.4e-1749.100584674584674SH2 domain
oncogene, tumor suppressor90.5368.383STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain
Tnk2

Domain structure obtained by HMM

Protein ID: XP_008836758.1 - activated CDC42 kinase 1 isoform X1
KEEG Ortholog ID: K08886
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SAM_2PF07647660.0000310.40046974199SAM domain (Sterile alpha motif)
Pkinase_TyrPF077142609.1e-91289.800159417158417Protein tyrosine kinase
SH3_9PF14604490.000000000000006841.000427476427476Variant SH3 domain
GTPase_bindingPF09027681.1e-49152.600479546479546GTPase binding
Inhibitor_Mig-6PF11555601.5e-3091.400821886821887EGFR receptor inhibitor Mig-6
UBA_4PF14555430.0000002416.8001007104010061041UBA-like domain
UBA_4PF14555430.00000412.9001057107210551075UBA-like domain
interactor70.6674.500SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SH3_9 (PF14604): Variant SH3 domain
GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
Tubb4b

Domain structure obtained by HMM

Protein ID: XP_008829427.1 - tubulin beta-4B chain
KEEG Ortholog ID: K07375
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TubulinPF000911976.4e-73231.30032113212Tubulin/FtsZ family, GTPase domain
Tubulin_CPF039531256.8e-47145.100261381261382Tubulin C-terminal domain
interactor80.50010.500Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Tubgcp2

Domain structure obtained by HMM

Protein ID: XP_008821393.1 - gamma-tubulin complex component 2 isoform X1
KEEG Ortholog ID: K16569
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF2894PF114451870.00001711.5006515627159Protein of unknown function (DUF2894)
Spc97_Spc98PF041305402.5e-125405.300219737219737Spc97 / Spc98 family
zf-Tim10_DDPPF02953640.000002613.400715770710773Tim10/DDP family zinc finger
interactor30.6670.500DUF2894 (PF11445): Protein of unknown function (DUF2894)
Spc97_Spc98 (PF04130): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger
Vim

Domain structure obtained by HMM

Protein ID: XP_008832116.1 - vimentin
KEEG Ortholog ID: K07606
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Filament_headPF04732873.2e-2472.00071016101Intermediate filament head (DNA binding) region
FilamentPF000383126.9e-118379.800102410102410Intermediate filament protein
tumor suppressor31.0000Filament_head (PF04732): Intermediate filament head (DNA binding) region
Filament (PF00038): Intermediate filament protein
Zc3hc1

Domain structure obtained by HMM

Protein ID: XP_008844570.1 - nuclear-interacting partner of ALK isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-C3HCPF079671344.9e-39119.6007319972201C3HC zinc finger-like
Rsm1PF08600920.00000000000004838.600248289248341Rsm1-like
Yippee-Mis18PF032261050.000377.000264301224308Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Rsm1PF08600920.00000007718.800411461403466Rsm1-like
interactor21.0000zf-C3HC (PF07967): C3HC zinc finger-like
Rsm1 (PF08600): Rsm1-like
Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

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