Find Protein-Protein Interactions (PPI) Network

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Powered by Cytoscape Web taxid = 1026970 for: protein(s) Alk (from a repository: Thu Jun 21 05:03:31 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins22 (36.07 %)
The number (and %) of the tumor suppressors10 (16.39 %)
Total number of binary PPIs (saturation %)214 (11.69 %)
The number (and %) of affected PPIs60 (28.04 %)
PPI diameter2
PPI radius1
The average degree of PPI6.131
Assortativity coefficient-0.4619
The network average Clustering coefficient0.545
The number (and %) of a zero Clustering coefficients12 (19.67 %)
The number (and %) of a zero Betweenness Centrality24 (39.34 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Alk
user protein, oncogene600.0722735.633MAM (PF00629): MAM domain, meprin/A5/mu
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Actb
oncogene80.6196.000Actin (PF00022): Actin
Actn4
interactor31.0000CH (PF00307): Calponin homology (CH) domain
Uds1 (PF15456): Up-regulated During Septation
Spectrin (PF00435): Spectrin repeat
EF-hand_7 (PF13499): EF-hand domain pair
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand
Bcar1
oncogene60.8671.000SH3_1 (PF00018): SH3 domain
Extensin_2 (PF04554): Extensin-like region
Serine_rich (PF08824): Serine rich protein interaction domain
DUF3513 (PF12026): Domain of unknown function (DUF3513)
Bicd2
interactor100HALZ (PF02183): Homeobox associated leucine zipper
BicD (PF09730): Microtubule-associated protein Bicaudal-D
DUF4666 (PF15697): Domain of unknown function (DUF4666)
Cdk13
interactor40.8330.667K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
Macoilin (PF09726): Transmembrane protein
THRAP3_BCLAF1 (PF15440): THRAP3/BCLAF1 family
CPSF100_C (PF13299): Cleavage and polyadenylation factor 2 C-terminal
Pkinase (PF00069): Protein kinase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Cdk9
interactor60.7002.167Pkinase (PF00069): Protein kinase domain
Cenpf
oncogene31.0000CENP-F_N (PF10481): Cenp-F N-terminal domain
Fez1 (PF06818): Fez1
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
DivIVA (PF05103): DivIVA protein
bZIP_1 (PF00170): bZIP transcription factor
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Tup_N (PF08581): Tup N-terminal
Sec20 (PF03908): Sec20
DUF3450 (PF11932): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
DPM3 (PF08285): Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Spc7 (PF08317): Spc7 kinetochore protein
GIT_CC (PF16559): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF972 (PF06156): Protein of unknown function (DUF972)
Bcr-Abl_Oligo (PF09036): Bcr-Abl oncoprotein oligomerisation domain
E2F_CC-MB (PF16421): E2F transcription factor CC-MB domain
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Cep57_MT_bd (PF06657): Centrosome microtubule-binding domain of Cep57
CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
APG6 (PF04111): Autophagy protein Apg6
DUF5082 (PF16888): Domain of unknown function (DUF5082)
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
HALZ (PF02183): Homeobox associated leucine zipper
CENP-F_C_Rb_bdg (PF10490): Rb-binding domain of kinetochore protein Cenp-F/LEK1
Coro1c
oncogene41.0000DUF1899 (PF08953): Domain of unknown function (DUF1899)
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
Eif4b
interactor31.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609): Wound-induced protein
Epha1
oncogene, tumor suppressor30.6670.500Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Ephb2
tumor suppressor41.0000Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Errfi1
oncogene, tumor suppressor60.8000.917GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6
Flii
oncogene40.6670.900LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
Gelsolin (PF00626): Gelsolin repeat
Gak
oncogene30.6671.000Pkinase (PF00069): Protein kinase domain
Y_phosphatase (PF00102): Protein-tyrosine phosphatase
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
DnaJ (PF00226): DnaJ domain
Grb2
oncogene230.264133.533SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
DUF5093 (PF17011): Domain of unknown function (DUF5093)
Hsp90aa1
oncogene190.26889.483HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Hspd1
oncogene, tumor suppressor50.7002.000Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family
Ikbkg
interactor100.38917.900NEMO (PF11577): NF-kappa-B essential modulator NEMO
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5 (PF09787): Golgin subfamily A member 5
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1 (PF14945): Normal lung function maintenance, Low in Lung Cancer 1 protein
Irf7
interactor200IRF (PF00605): Interferon regulatory factor transcription factor
IRF-3 (PF10401): Interferon-regulatory factor 3
Irs1
interactor70.7143.833PH (PF00169): PH domain
IRS (PF02174): PTB domain (IRS-1 type)
Irs4
interactor40.8330.250TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
IRS (PF02174): PTB domain (IRS-1 type)
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Jak2
oncogene140.50022.533FERM_M (PF00373): FERM central domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Jak3
oncogene50.7001.567APH (PF01636): Phosphotransferase enzyme family
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Krt18
interactor80.38110.067Filament (PF00038): Intermediate filament protein
Spc7 (PF08317): Spc7 kinetochore protein
Map2k7
interactor60.6003.567Pkinase (PF00069): Protein kinase domain
Map3k1
oncogene70.4675.567Phostensin_N (PF13916): PP1-regulatory protein, Phostensin N-terminal
zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639): Ring finger domain
Pkinase (PF00069): Protein kinase domain
Map3k5
oncogene80.5716.250DUF4071 (PF13281): Domain of unknown function (DUF4071)
Pkinase (PF00069): Protein kinase domain
FPP (PF05911): Filament-like plant protein, long coiled-coil
Mapk1
oncogene90.35713.317Pkinase (PF00069): Protein kinase domain
Mapk8ip3
interactor50.6002.067Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
Med21 (PF11221): Subunit 21 of Mediator complex
ERM (PF00769): Ezrin/radixin/moesin family
UPF0449 (PF15136): Uncharacterised protein family UPF0449
Mep1b
interactor100Astacin (PF01400): Astacin (Peptidase family M12A)
MAM (PF00629): MAM domain, meprin/A5/mu
EGF (PF00008): EGF-like domain
LRRC37AB_C (PF14914): LRRC37A/B like protein 1 C-terminal domain
Mtif2
interactor100GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4
Dynamin_N (PF00350): Dynamin family
IF-2 (PF11987): Translation-initiation factor 2
Mybpc2
interactor100I-set (PF07679): Immunoglobulin I-set domain
fn3 (PF00041): Fibronectin type III domain
Myh10
interactor31.0000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Myh9
oncogene, tumor suppressor120.31839.000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576): Myosin tail
Mylk
interactor30.6670.500I-set (PF07679): Immunoglobulin I-set domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
fn3 (PF00041): Fibronectin type III domain
Pkinase (PF00069): Protein kinase domain
Myo6
interactor40.6671.000Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
IQ (PF00612): IQ calmodulin-binding motif
IncA (PF04156): IncA protein
PseudoU_synth_2 (PF00849): RNA pseudouridylate synthase
Agouti (PF05039): Agouti protein
Sec62 (PF03839): Translocation protein Sec62
Myosin-VI_CBD (PF16521): Myosin VI cargo binding domain
Pdlim3
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936): Domain of unknown function (DUF4749)
LIM (PF00412): LIM domain
Pdx1
oncogene, tumor suppressor100Homeobox (PF00046): Homeobox domain
TMEM171 (PF15471): Transmembrane protein family 171
Pik3cb
interactor, oncogene41.0000Tom37_C (PF11801): Tom37 C-terminal domain
PI3K_p85B (PF02192): PI3-kinase family, p85-binding domain
RWD (PF05773): RWD domain
DUF4381 (PF14316): Domain of unknown function (DUF4381)
PI3K_rbd (PF00794): PI3-kinase family, ras-binding domain
PI3K_C2 (PF00792): Phosphoinositide 3-kinase C2
PI3Ka (PF00613): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase
Pik3r1
oncogene140.43626.350SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Plcb2
oncogene200EF-hand_like (PF09279): Phosphoinositide-specific phospholipase C, efhand-like
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF1154 (PF06631): Protein of unknown function (DUF1154)
PKK (PF12474): Polo kinase kinase
PLC-beta_C (PF08703): PLC-beta C terminal
Plcg1
oncogene70.6195.583PH_12 (PF16457): Pleckstrin homology domain
PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain
PH (PF00169): PH domain
SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain
C2 (PF00168): C2 domain
Prkcq
interactor41.0000DUF1272 (PF06906): Protein of unknown function (DUF1272)
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Ptn
oncogene31.0000UPF0239 (PF06783): Uncharacterised protein family (UPF0239)
PTN_MK_N (PF05196): PTN/MK heparin-binding protein family, N-terminal domain
PTN_MK_C (PF01091): PTN/MK heparin-binding protein family, C-terminal domain
YqzE (PF14038): YqzE-like protein
Pxn
oncogene60.8001.467Paxillin (PF03535): Paxillin family
Gin (PF10764): Inhibitor of sigma-G Gin
LIM (PF00412): LIM domain
Rab35
oncogene100Ras (PF00071): Ras family
Rack1
oncogene, tumor suppressor50.6672.000WD40 (PF00400): WD domain, G-beta repeat
Rad17
interactor100Mvb12 (PF09452): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Shc1
oncogene160.32450.817PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Shc3
interactor21.0000PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Smc6
interactor200AAA_23 (PF13476): AAA domain
DASH_Spc19 (PF08287): Spc19
DUF4988 (PF16378): Domain of unknown function
Phage_GP20 (PF06810): Phage minor structural protein GP20
DUF16 (PF01519): Protein of unknown function DUF16
Spc29 (PF17082): Spindle Pole Component 29
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046): Biogenesis of lysosome-related organelles complex-1 subunit 2
Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain
DUF3993 (PF13158): Protein of unknown function (DUF3993)
Socs1
oncogene, tumor suppressor60.8670.900SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Socs5
interactor100SOCS (PF12610): Suppressor of cytokine signalling
SH2 (PF00017): SH2 domain
SOCS_box (PF07525): SOCS box
Src
oncogene180.30173.783SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Stat3
oncogene, tumor suppressor90.5368.383STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain
Tnk2
interactor70.6674.500SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SH3_9 (PF14604): Variant SH3 domain
GTPase_binding (PF09027): GTPase binding
Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
Tubb4b
interactor80.50010.500Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Tubgcp2
interactor30.6670.500DUF2894 (PF11445): Protein of unknown function (DUF2894)
Spc97_Spc98 (PF04130): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger
Vim
tumor suppressor31.0000Filament_head (PF04732): Intermediate filament head (DNA binding) region
Filament (PF00038): Intermediate filament protein
Zc3hc1
interactor21.0000zf-C3HC (PF07967): C3HC zinc finger-like
Rsm1 (PF08600): Rsm1-like
Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

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