Alk
| user protein, oncogene | 60 | 0.072 | 2735.633 | MAM (PF00629): MAM domain, meprin/A5/mu Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site Pkinase_Tyr (PF07714): Protein tyrosine kinase |
Actb
| oncogene | 8 | 0.619 | 6.000 | Actin (PF00022): Actin |
Actn4
| interactor | 3 | 1.000 | 0 | CH (PF00307): Calponin homology (CH) domain Uds1 (PF15456): Up-regulated During Septation Spectrin (PF00435): Spectrin repeat EF-hand_7 (PF13499): EF-hand domain pair EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand |
Bcar1
| oncogene | 6 | 0.867 | 1.000 | SH3_1 (PF00018): SH3 domain Extensin_2 (PF04554): Extensin-like region Serine_rich (PF08824): Serine rich protein interaction domain DUF3513 (PF12026): Domain of unknown function (DUF3513) |
Bicd2
| interactor | 1 | 0 | 0 | HALZ (PF02183): Homeobox associated leucine zipper BicD (PF09730): Microtubule-associated protein Bicaudal-D DUF4666 (PF15697): Domain of unknown function (DUF4666) |
Cdk13
| interactor | 4 | 0.833 | 0.667 | K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain Macoilin (PF09726): Transmembrane protein THRAP3_BCLAF1 (PF15440): THRAP3/BCLAF1 family CPSF100_C (PF13299): Cleavage and polyadenylation factor 2 C-terminal Pkinase (PF00069): Protein kinase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
Cdk9
| interactor | 6 | 0.700 | 2.167 | Pkinase (PF00069): Protein kinase domain |
Cenpf
| oncogene | 3 | 1.000 | 0 | CENP-F_N (PF10481): Cenp-F N-terminal domain Fez1 (PF06818): Fez1 TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein DivIVA (PF05103): DivIVA protein bZIP_1 (PF00170): bZIP transcription factor DUF1664 (PF07889): Protein of unknown function (DUF1664) Tup_N (PF08581): Tup N-terminal Sec20 (PF03908): Sec20 DUF3450 (PF11932): Protein of unknown function (DUF3450) TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding DPM3 (PF08285): Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Spc7 (PF08317): Spc7 kinetochore protein GIT_CC (PF16559): GIT coiled-coil Rho guanine nucleotide exchange factor DUF972 (PF06156): Protein of unknown function (DUF972) Bcr-Abl_Oligo (PF09036): Bcr-Abl oncoprotein oligomerisation domain E2F_CC-MB (PF16421): E2F transcription factor CC-MB domain CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1 Cep57_MT_bd (PF06657): Centrosome microtubule-binding domain of Cep57 CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 (PF04111): Autophagy protein Apg6 DUF5082 (PF16888): Domain of unknown function (DUF5082) ADIP (PF11559): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding HALZ (PF02183): Homeobox associated leucine zipper CENP-F_C_Rb_bdg (PF10490): Rb-binding domain of kinetochore protein Cenp-F/LEK1 |
Coro1c
| oncogene | 4 | 1.000 | 0 | DUF1899 (PF08953): Domain of unknown function (DUF1899) WD40 (PF00400): WD domain, G-beta repeat ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat |
Eif4b
| interactor | 3 | 1.000 | 0 | RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3774 (PF12609): Wound-induced protein |
Epha1
| oncogene, tumor suppressor | 3 | 0.667 | 0.500 | Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain Ephrin_rec_like (PF07699): Putative ephrin-receptor like fn3 (PF00041): Fibronectin type III domain EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain Pkinase_Tyr (PF07714): Protein tyrosine kinase SAM_1 (PF00536): SAM domain (Sterile alpha motif) |
Ephb2
| tumor suppressor | 4 | 1.000 | 0 | Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain EGF_2 (PF07974): EGF-like domain cEGF (PF12662): Complement Clr-like EGF-like Ephrin_rec_like (PF07699): Putative ephrin-receptor like fn3 (PF00041): Fibronectin type III domain EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain Pkinase_Tyr (PF07714): Protein tyrosine kinase SAM_1 (PF00536): SAM domain (Sterile alpha motif) |
Errfi1
| oncogene, tumor suppressor | 6 | 0.800 | 0.917 | GTPase_binding (PF09027): GTPase binding Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6 |
Flii
| oncogene | 4 | 0.667 | 0.900 | LRR_4 (PF12799): Leucine Rich repeats (2 copies) LRR_8 (PF13855): Leucine rich repeat LRR_1 (PF00560): Leucine Rich Repeat SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal Gelsolin (PF00626): Gelsolin repeat |
Gak
| oncogene | 3 | 0.667 | 1.000 | Pkinase (PF00069): Protein kinase domain Y_phosphatase (PF00102): Protein-tyrosine phosphatase DSPc (PF00782): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein DnaJ (PF00226): DnaJ domain |
Grb2
| oncogene | 23 | 0.264 | 133.533 | SH3_1 (PF00018): SH3 domain SH2 (PF00017): SH2 domain DUF5093 (PF17011): Domain of unknown function (DUF5093) |
Hsp90aa1
| oncogene | 19 | 0.268 | 89.483 | HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183): Hsp90 protein |
Hspd1
| oncogene, tumor suppressor | 5 | 0.700 | 2.000 | Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family |
Ikbkg
| interactor | 10 | 0.389 | 17.900 | NEMO (PF11577): NF-kappa-B essential modulator NEMO APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 Golgin_A5 (PF09787): Golgin subfamily A member 5 CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator LLC1 (PF14945): Normal lung function maintenance, Low in Lung Cancer 1 protein |
Irf7
| interactor | 2 | 0 | 0 | IRF (PF00605): Interferon regulatory factor transcription factor IRF-3 (PF10401): Interferon-regulatory factor 3 |
Irs1
| interactor | 7 | 0.714 | 3.833 | PH (PF00169): PH domain IRS (PF02174): PTB domain (IRS-1 type) |
Irs4
| interactor | 4 | 0.833 | 0.250 | TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain IRS (PF02174): PTB domain (IRS-1 type) CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal Ribosomal_60s (PF00428): 60s Acidic ribosomal protein |
Jak2
| oncogene | 14 | 0.500 | 22.533 | FERM_M (PF00373): FERM central domain SH2 (PF00017): SH2 domain Pkinase_Tyr (PF07714): Protein tyrosine kinase |
Jak3
| oncogene | 5 | 0.700 | 1.567 | APH (PF01636): Phosphotransferase enzyme family SH2 (PF00017): SH2 domain Pkinase_Tyr (PF07714): Protein tyrosine kinase |
Krt18
| interactor | 8 | 0.381 | 10.067 | Filament (PF00038): Intermediate filament protein Spc7 (PF08317): Spc7 kinetochore protein |
Map2k7
| interactor | 6 | 0.600 | 3.567 | Pkinase (PF00069): Protein kinase domain |
Map3k1
| oncogene | 7 | 0.467 | 5.567 | Phostensin_N (PF13916): PP1-regulatory protein, Phostensin N-terminal zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding zf-RING_2 (PF13639): Ring finger domain Pkinase (PF00069): Protein kinase domain |
Map3k5
| oncogene | 8 | 0.571 | 6.250 | DUF4071 (PF13281): Domain of unknown function (DUF4071) Pkinase (PF00069): Protein kinase domain FPP (PF05911): Filament-like plant protein, long coiled-coil |
Mapk1
| oncogene | 9 | 0.357 | 13.317 | Pkinase (PF00069): Protein kinase domain |
Mapk8ip3
| interactor | 5 | 0.600 | 2.067 | Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1 JIP_LZII (PF16471): JNK-interacting protein leucine zipper II Med21 (PF11221): Subunit 21 of Mediator complex ERM (PF00769): Ezrin/radixin/moesin family UPF0449 (PF15136): Uncharacterised protein family UPF0449 |
Mep1b
| interactor | 1 | 0 | 0 | Astacin (PF01400): Astacin (Peptidase family M12A) MAM (PF00629): MAM domain, meprin/A5/mu EGF (PF00008): EGF-like domain LRRC37AB_C (PF14914): LRRC37A/B like protein 1 C-terminal domain |
Mtif2
| interactor | 1 | 0 | 0 | GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain GTP_EFTU_D4 (PF14578): Elongation factor Tu domain 4 Dynamin_N (PF00350): Dynamin family IF-2 (PF11987): Translation-initiation factor 2 |
Mybpc2
| interactor | 1 | 0 | 0 | I-set (PF07679): Immunoglobulin I-set domain fn3 (PF00041): Fibronectin type III domain |
Myh10
| interactor | 3 | 1.000 | 0 | Myosin_N (PF02736): Myosin N-terminal SH3-like domain Myosin_head (PF00063): Myosin head (motor domain) IQ (PF00612): IQ calmodulin-binding motif Myosin_tail_1 (PF01576): Myosin tail |
Myh9
| oncogene, tumor suppressor | 12 | 0.318 | 39.000 | Myosin_N (PF02736): Myosin N-terminal SH3-like domain Myosin_head (PF00063): Myosin head (motor domain) IQ (PF00612): IQ calmodulin-binding motif Myosin_tail_1 (PF01576): Myosin tail |
Mylk
| interactor | 3 | 0.667 | 0.500 | I-set (PF07679): Immunoglobulin I-set domain 23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK fn3 (PF00041): Fibronectin type III domain Pkinase (PF00069): Protein kinase domain |
Myo6
| interactor | 4 | 0.667 | 1.000 | Myosin_N (PF02736): Myosin N-terminal SH3-like domain Myosin_head (PF00063): Myosin head (motor domain) IQ (PF00612): IQ calmodulin-binding motif IncA (PF04156): IncA protein PseudoU_synth_2 (PF00849): RNA pseudouridylate synthase Agouti (PF05039): Agouti protein Sec62 (PF03839): Translocation protein Sec62 Myosin-VI_CBD (PF16521): Myosin VI cargo binding domain |
Pdlim3
| interactor | 1 | 0 | 0 | PDZ (PF00595): PDZ domain (Also known as DHR or GLGF) DUF4749 (PF15936): Domain of unknown function (DUF4749) LIM (PF00412): LIM domain |
Pdx1
| oncogene, tumor suppressor | 1 | 0 | 0 | Homeobox (PF00046): Homeobox domain TMEM171 (PF15471): Transmembrane protein family 171 |
Pik3cb
| interactor, oncogene | 4 | 1.000 | 0 | Tom37_C (PF11801): Tom37 C-terminal domain PI3K_p85B (PF02192): PI3-kinase family, p85-binding domain RWD (PF05773): RWD domain DUF4381 (PF14316): Domain of unknown function (DUF4381) PI3K_rbd (PF00794): PI3-kinase family, ras-binding domain PI3K_C2 (PF00792): Phosphoinositide 3-kinase C2 PI3Ka (PF00613): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase |
Pik3r1
| oncogene | 14 | 0.436 | 26.350 | SH3_2 (PF07653): Variant SH3 domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal RhoGAP (PF00620): RhoGAP domain SH2 (PF00017): SH2 domain PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
Plcb2
| oncogene | 2 | 0 | 0 | EF-hand_like (PF09279): Phosphoinositide-specific phospholipase C, efhand-like PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain C2 (PF00168): C2 domain Ribosomal_60s (PF00428): 60s Acidic ribosomal protein DUF1154 (PF06631): Protein of unknown function (DUF1154) PKK (PF12474): Polo kinase kinase PLC-beta_C (PF08703): PLC-beta C terminal |
Plcg1
| oncogene | 7 | 0.619 | 5.583 | PH_12 (PF16457): Pleckstrin homology domain PI-PLC-X (PF00388): Phosphatidylinositol-specific phospholipase C, X domain PH (PF00169): PH domain SH2 (PF00017): SH2 domain SH3_1 (PF00018): SH3 domain PI-PLC-Y (PF00387): Phosphatidylinositol-specific phospholipase C, Y domain C2 (PF00168): C2 domain |
Prkcq
| interactor | 4 | 1.000 | 0 | DUF1272 (PF06906): Protein of unknown function (DUF1272) C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase (PF00069): Protein kinase domain Pkinase_C (PF00433): Protein kinase C terminal domain |
Ptn
| oncogene | 3 | 1.000 | 0 | UPF0239 (PF06783): Uncharacterised protein family (UPF0239) PTN_MK_N (PF05196): PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C (PF01091): PTN/MK heparin-binding protein family, C-terminal domain YqzE (PF14038): YqzE-like protein |
Pxn
| oncogene | 6 | 0.800 | 1.467 | Paxillin (PF03535): Paxillin family Gin (PF10764): Inhibitor of sigma-G Gin LIM (PF00412): LIM domain |
Rab35
| oncogene | 1 | 0 | 0 | Ras (PF00071): Ras family |
Rack1
| oncogene, tumor suppressor | 5 | 0.667 | 2.000 | WD40 (PF00400): WD domain, G-beta repeat |
Rad17
| interactor | 1 | 0 | 0 | Mvb12 (PF09452): ESCRT-I subunit Mvb12 Rad17 (PF03215): Rad17 cell cycle checkpoint protein |
Shc1
| oncogene | 16 | 0.324 | 50.817 | PID (PF00640): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017): SH2 domain |
Shc3
| interactor | 2 | 1.000 | 0 | PID (PF00640): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017): SH2 domain |
Smc6
| interactor | 2 | 0 | 0 | AAA_23 (PF13476): AAA domain DASH_Spc19 (PF08287): Spc19 DUF4988 (PF16378): Domain of unknown function Phage_GP20 (PF06810): Phage minor structural protein GP20 DUF16 (PF01519): Protein of unknown function DUF16 Spc29 (PF17082): Spindle Pole Component 29 TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein BLOC1_2 (PF10046): Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N (PF02403): Seryl-tRNA synthetase N-terminal domain DUF3993 (PF13158): Protein of unknown function (DUF3993) |
Socs1
| oncogene, tumor suppressor | 6 | 0.867 | 0.900 | SR-25 (PF10500): Nuclear RNA-splicing-associated protein SH2 (PF00017): SH2 domain SOCS_box (PF07525): SOCS box |
Socs5
| interactor | 1 | 0 | 0 | SOCS (PF12610): Suppressor of cytokine signalling SH2 (PF00017): SH2 domain SOCS_box (PF07525): SOCS box |
Src
| oncogene | 18 | 0.301 | 73.783 | SH3_1 (PF00018): SH3 domain SH2 (PF00017): SH2 domain Pkinase_Tyr (PF07714): Protein tyrosine kinase |
Stat3
| oncogene, tumor suppressor | 9 | 0.536 | 8.383 | STAT_int (PF02865): STAT protein, protein interaction domain STAT_alpha (PF01017): STAT protein, all-alpha domain STAT_bind (PF02864): STAT protein, DNA binding domain SH2 (PF00017): SH2 domain |
Tnk2
| interactor | 7 | 0.667 | 4.500 | SAM_2 (PF07647): SAM domain (Sterile alpha motif) Pkinase_Tyr (PF07714): Protein tyrosine kinase SH3_9 (PF14604): Variant SH3 domain GTPase_binding (PF09027): GTPase binding Inhibitor_Mig-6 (PF11555): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain |
Tubb4b
| interactor | 8 | 0.500 | 10.500 | Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953): Tubulin C-terminal domain |
Tubgcp2
| interactor | 3 | 0.667 | 0.500 | DUF2894 (PF11445): Protein of unknown function (DUF2894) Spc97_Spc98 (PF04130): Spc97 / Spc98 family zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger |
Vim
| tumor suppressor | 3 | 1.000 | 0 | Filament_head (PF04732): Intermediate filament head (DNA binding) region Filament (PF00038): Intermediate filament protein |
Zc3hc1
| interactor | 2 | 1.000 | 0 | zf-C3HC (PF07967): C3HC zinc finger-like Rsm1 (PF08600): Rsm1-like Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly |